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Bruton hastalığı zemininde gelişen PML olgusuna pediatrik radyoloji açısından bakış

Yıl 2017, Cilt: 1 Sayı: 3, 88 - 93, 18.12.2017

Öz

Jc papovavirüs nörontropik virüs olup oligodendrositlerde
demyelinizasyona neden olmaktadır. Difüzyon tensör incelemede beyaz cevher
yolaklarında sağ frontal bölgede kesinti izlenmektedir. Multivoksel
spektroskopi incelemede Cho/Cr ve mI/Cr oranlarında artış izlenirken NAA miktarlarında
düşme izlenmektedir.



Bu bulgular demyelinizan hasarı gösterir-ken, mI
hastalığın şiddetini göstermektedir. Bizim bu çalışmada amacımız ileri MRG
tekniklerini kullanarak immün yetmezlik olan bir olguda gelişen PML
hastalığının bulgularını tartışmaktır. 

Kaynakça

  • Referanslar:
  • Referans1. Buckle C CM (2010) Use of diffusion -weighted imaging to evaluate the inital response of progressive multifocal leukoencephalopathy to highly active antiviral therapy;early experience. AJNR Am J Neuroradiol 31:1031–1035.
  • Referans2. Bag AK ,Cure JK,Chapman PR, Roberson GH SR (2010) JC virus infection of the brain. AJNR Am J Neuroradiol 31:1564–1576.
  • 3. Huisman TAGM, Boltshauser E, Martin E, Nadal D (2005) Diffusion tensor imaging in progressive multifocal leukoencephalopathy: early predictor for demyelination? AJNR Am J Neuroradiol 26:2153–6. doi: 26/8/2153
  • Referans4. Bag a K, Curé JK, Chapman PR, et al. (2010) JC virus infection of the brain. AJNR Am J Neuroradiol 31:1564–1576. doi: 10.3174/ajnr.A2035
  • Referans5. Akiyama M , Takahashi T , Nomura S, Yamashita Y HK (2010) Progressive multifocal leukoencephalopathy in a patient with multiple myeloma. Int J hematol 92:186–189.
  • Referans6. Usiskin SI , Bainbridge A, Miller RF et al (2007) Progressive multifocal leukoencephalopathy ;serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy. AJNR Am J Neuroradiol 28:285–86.
  • Referans7. Ungunkhuyag MM, Arada MH, Be TA, Ujita KF (2014) Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma. Magn Reson Med Sci 13:55–59. doi: 10.2463/mrms.2013-0037
  • Referans8. Küker W , Madera I NT et al (2006) Progressive multifocal leukoencephalopathy ; value of diffusion -weighted and contrast -enhanced magnetic resonance imaging for diagnosis and treatment control. Eur J Neurol 13:819–826. Referans9. Sag AT, Saka E, Ozgur TT, et al .Progressive neurodegenerative syndrome in a patient with X-linked agammaglobulinemia receiving intravenous immunoglobulin therapy. Cogn Behav Neurol. 2014 Sep;27(3):155-9. Referans10. Timmers I, Roebroeck A, Bastiani M, et al . Assessing Microstructural Substrates of White Matter Abnormalities: A Comparative Study Using DTI and NODDI. PLoS One. 2016 Dec 21;11(12):e0167884

The role of advanced magnetic resonance imaging techniques in a pediatric Progressive Multifocal Leukoencephalopathy patient associated with Bruton disease : The pediatric radiologist ‘s approach within a case report

Yıl 2017, Cilt: 1 Sayı: 3, 88 - 93, 18.12.2017

Öz

JC
papovavirus, which is a neurotropic virus, causes a demyelinating process in
oligodendrocytes. Diffusion tensor imaging (DTI) showed white-matter tract
interruptions in the right frontal hemispheric region. Multivoxel spectroscopy
revealed an increase in the Cho/Cr and mI/Cr ratios, and a decreased in the
N-acetylaspartate (NAA) values. These values show the demyelinating process and
damage, whereas mI levels are known to be the predictor of the severity of the
dis-ease. In this case report, our goal is to discuss the supportive findings
and benefits of using advanced MR techniques in an immunocompromised pediatric
patient suffering from PML disease. 

Kaynakça

  • Referanslar:
  • Referans1. Buckle C CM (2010) Use of diffusion -weighted imaging to evaluate the inital response of progressive multifocal leukoencephalopathy to highly active antiviral therapy;early experience. AJNR Am J Neuroradiol 31:1031–1035.
  • Referans2. Bag AK ,Cure JK,Chapman PR, Roberson GH SR (2010) JC virus infection of the brain. AJNR Am J Neuroradiol 31:1564–1576.
  • 3. Huisman TAGM, Boltshauser E, Martin E, Nadal D (2005) Diffusion tensor imaging in progressive multifocal leukoencephalopathy: early predictor for demyelination? AJNR Am J Neuroradiol 26:2153–6. doi: 26/8/2153
  • Referans4. Bag a K, Curé JK, Chapman PR, et al. (2010) JC virus infection of the brain. AJNR Am J Neuroradiol 31:1564–1576. doi: 10.3174/ajnr.A2035
  • Referans5. Akiyama M , Takahashi T , Nomura S, Yamashita Y HK (2010) Progressive multifocal leukoencephalopathy in a patient with multiple myeloma. Int J hematol 92:186–189.
  • Referans6. Usiskin SI , Bainbridge A, Miller RF et al (2007) Progressive multifocal leukoencephalopathy ;serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy. AJNR Am J Neuroradiol 28:285–86.
  • Referans7. Ungunkhuyag MM, Arada MH, Be TA, Ujita KF (2014) Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma. Magn Reson Med Sci 13:55–59. doi: 10.2463/mrms.2013-0037
  • Referans8. Küker W , Madera I NT et al (2006) Progressive multifocal leukoencephalopathy ; value of diffusion -weighted and contrast -enhanced magnetic resonance imaging for diagnosis and treatment control. Eur J Neurol 13:819–826. Referans9. Sag AT, Saka E, Ozgur TT, et al .Progressive neurodegenerative syndrome in a patient with X-linked agammaglobulinemia receiving intravenous immunoglobulin therapy. Cogn Behav Neurol. 2014 Sep;27(3):155-9. Referans10. Timmers I, Roebroeck A, Bastiani M, et al . Assessing Microstructural Substrates of White Matter Abnormalities: A Comparative Study Using DTI and NODDI. PLoS One. 2016 Dec 21;11(12):e0167884
Toplam 9 adet kaynakça vardır.

Ayrıntılar

Konular Klinik Tıp Bilimleri
Bölüm OLGU SUNUMU
Yazarlar

Mehmet Burak Ozkan

Meltem Ceyhan Bilgici Bu kişi benim

Alişan Yildiran Bu kişi benim

Yayımlanma Tarihi 18 Aralık 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 1 Sayı: 3

Kaynak Göster

APA Ozkan, M. B., Ceyhan Bilgici, M., & Yildiran, A. (2017). Bruton hastalığı zemininde gelişen PML olgusuna pediatrik radyoloji açısından bakış. Balıkesir Medical Journal, 1(3), 88-93.