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Kolon Poliplerinin Ayırıcı Tanısında Yeni Bir Yaklaşım; Stereoloji

Yıl 2021, Cilt: 5 Sayı: 1, 60 - 71, 28.02.2021
https://doi.org/10.33716/bmedj.885281

Öz

Amaç: Bu çalışmanın amacı; neoplastik potansiyeli de olabilen kolon poliplerinin histopatolojik özelliklerine göre sınıflandığında tanı güçlüğü oluşturabilen olgular için tanıda kullanılabilecek stereoloji yönteminin değerini araştırmaktır.
Gereç ve Yöntemler: Bu çalışmaya 236 adet kolorektal polip olgusu dahil edilmiş ve olgular Dünya Sağlık Örgütü’nün 2010 yılı sınıflamasına göre histomorfolojik özellikleri göz önüne alınarak hiperplastik polip, serrated adenom, tübüler adenom, tübülövillöz adenom, villöz adenom şeklinde gruplara ayrılmıştır. Olguların stereolojik yöntemler ile ölçümleri yapılarak elde edilen veriler karşılaştırılmıştır.
Bulgular: Olgular cinsiyetlerine göre değerlendirildiğinde erkek cinsiyet ağırlıktaydı. Stereolojik ölçümler sonucu elde edilen veriler gruplar arasında karşılaştırıldığında birçok parametrede farklılıklar mevcuttu.
Sonuç: Poliplerin sınıflandırılmasında histopatolojik özellikler yanısıra stereolojik çalışmalar da kıymetlidir.

Destekleyen Kurum

Herhangi bir destekleyen kurum yoktur

Teşekkür

Çalışmanın istatistiksel analizini yapmış olan Dr. Aysun Aras' a teşekkür ederiz

Kaynakça

  • 1. Kumar W, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. Çeviri: Sav A, Özdamar Ş.Ü. Hastalığın Patolojik Temeli. Ankara: Güneş Tıp Kitapevleri Ltd Şti, 2009:797-875.
  • 2. Eminler AT, Sakallı M, Kader Irak K, Ayyıldız T, Keskin M, Gülten İY ve ark. Gastroenteroloji ünitemizdeki kolonoskopik polipektomi sonuçlarımız, Akademik Gastroenteroloji Dergisi, 2011:10;112-115.
  • 3. Aslan F, Turan G, Altun E. Kuşakçıoğlu Ö. Kolorektal Kanser Hastalıkları. İstanbul: Nobel Tıp Kitabevleri Ltd.Şti. 2003: 1-239. Balıkesir ilindeki kolorektal polipektomi olgularının değerlendirilmesi, Balıkesir Medical Journal, 2017:1(3); 104-107.
  • 4. Yarıkkaya E, Erdoğan Durmuş Ş, Demirtaş R. Kolorektal poliplerin klinikopatolojik özellikleri: Türkiye'nin Kuzey-Doğu Anadolu Bölgesinden retrospektif bir çalışma, Balıkesir Med. Journal, 2018:2(3); 178-184.
  • 5. Suh S, Kang M, Kim MY, Chung HS, Kim SK, Hur KY. et al. Korean Type 2 Diabetes Patients have Multiple Adenomatous Polyps Compared to Non-diabetic Controls, J Korean Med Sci, 2011: 26(9); 1196–1200.
  • 6. Odze RD, Noffsinger AE. Neoplastic Diseases of the small and large intestines. In Silverberg S.G (ed) Silverberg’s Principles and Practice of Surgical Pathology and Cytopathology. China: Elsevier Inc, 2006: 1419-1464.
  • 7. Bosman FT, Carnerio F, Hruban RH et al. WHO Classification of Tumours of the Digestive System. Lyon: IARCPress. 2010: 132-73.
  • 8. Terry MB, Neugut A, Bostick A, Potter JD. Haile R, Fenoglio Preiser C. Reliability in the Classification of Advanced Colorectal Adenomas, Cancer Epidemiol Biomarkers Prev, 2002: 11; 660.
  • 9. Gundersen HJG. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in memory of William R Thomson, J Microsc, 1986: 143; 3-45.
  • 10. Cruz-Orive LM, Weibel ER. Recent stereological methods for cell biology: a brief survey, Cell Mol Psysiol, 1990: 2; 48–56.
  • 11. Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N et al. The new stereological tools: Disector, fractionator, nucleator, and point sampled intercepts and their use in pathological research and diagnosis, APMIS, 1988a; 96; 857–881.
  • 12. Canan S, Çolakoğlu S., Şahin B, Ünal B, Aslan H, Kaplan S, içinde: Cavalieri Prensibi ile Hacim Hesaplanması, Sinir Biliminde Temel Metotlar ve Stereoloji Kursu, Kurs notları 27 Ekim-6 Kasım 2006 Erzurum, sf. 1-27.
  • 13. Unbiased Stereology, Three Dimensional Measurement in Microscopy, second edition, C.V. Howard & M.G. Reed, bios scientific publishers, Oxford 1998, p. 63.
  • 14. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008, CA Cancer J Clin 2008:58; 71-96.
  • 15. Fong TV, Chuah SK, Chiou SS, Chiu KW, Hsu CC, Chiu YC, et al. Correlation of the morphology and size of colonic polyps with their histology, Chang Gung Med J, 2003: 26; 339-343.
  • 16. Cappell MS. Pathophysiology, clinical presentation, and management of colon cancer, Gastroenterol Clin North Am, 2008: 37;1-24.
  • 17. Bond J. H. Polyp guideline: diagnosis, treatment, and surveillance for patients with nonfamilial colorectal polyps. The Practice Parameters Committee of the American College of Gastroenterology, Ann. Int. Med, 1993: 119; 836-843.
  • 18. Atkin W. S., Morson B. C., Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N. Engl. J. Med. 1992;326: 658-662.
  • 19. Otchy DP, Ransohoff DF, Wolff BG, Weaver A, Ilstrup D, Carlson H et al. Metachronous colon cancer in persons who have had a large adenomatous polyp, Am. J. Gastroenterol, 1996:91; 448-454.
  • 20. Noshirwani KC., van Stolk RU, Rybicki LA, Beck GJ. Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy. Gastrointest. Endosc, 2000: 51; 433-437.
  • 21. Liu HH, Wu CM, Peng Y, Wu MS. Prevalence of advanced colonic polyps in asymptomatic, Chinese World J Gastroenterol, 2005:11(30);4731-4734.
  • 22. Pandergrass CJ, Edelstein DL, Hylind LM, Phillips BT, Donahue CI, Romans K et al. Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy study, Clin Gastroenterol Hepatol, 2008: 6(9);1011-1015.
  • 23. Elias H, Hyde D, Mullens R, Lambert FC. Colonic adenomas: stereology and growth mechanisms, Diseases of the colon & rectum, 1981: 24 (5);331-342.
  • 24. Pesce C. M, Colacino R. Relative growth of adenomatous polyps of the colon. Stereology and allometry of multiple polyposis, Virchows Arch A 1987: 412;151-154.
  • 25. Lane N, Lev R. Observations on the origin of adenomatous epithelium of the colon. Serial section studies of minute polyps in familial polyposis, Cancer, 1963: 16;751-764.
  • 26. Meijer GA, Fleege JC, Beak JP. Stereoloical assesment of architectural changes in dysplastic epithlium of colorectal adenomas, Pathol Res Pact, 1994:190(4);331-41.

A New Approach in Differential Diagnosis of Colon Polyps; Stereology

Yıl 2021, Cilt: 5 Sayı: 1, 60 - 71, 28.02.2021
https://doi.org/10.33716/bmedj.885281

Öz

Aim: The aim of this study is; to investigate the value of the stereology method that can be used in the diagnosis of colon polyps, which may also have neoplastic potential and have diagnostic difficulties based on histopathological classification.
Materials and Methods: In this study, 236 cases of colorectal polyps were included and according to the histomorphological features determined in the World Health Organization classification of 2010. The cases were grouped as hyperplastic polyps, serrated adenomas, tubular adenomas, tübülövillöz adenoma and villous adenoma. They were measured with the stereological methods and the data obtained were compared.
Results: When the cases were evaluated according to their gender, male gender was predominant. When the data obtained as a result of stereological measurements were compared between the groups, there were differences in many parameters.
Conclusion: In addition to histopathological features, stereological studies are also valuable in classifying polyps.

Kaynakça

  • 1. Kumar W, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. Çeviri: Sav A, Özdamar Ş.Ü. Hastalığın Patolojik Temeli. Ankara: Güneş Tıp Kitapevleri Ltd Şti, 2009:797-875.
  • 2. Eminler AT, Sakallı M, Kader Irak K, Ayyıldız T, Keskin M, Gülten İY ve ark. Gastroenteroloji ünitemizdeki kolonoskopik polipektomi sonuçlarımız, Akademik Gastroenteroloji Dergisi, 2011:10;112-115.
  • 3. Aslan F, Turan G, Altun E. Kuşakçıoğlu Ö. Kolorektal Kanser Hastalıkları. İstanbul: Nobel Tıp Kitabevleri Ltd.Şti. 2003: 1-239. Balıkesir ilindeki kolorektal polipektomi olgularının değerlendirilmesi, Balıkesir Medical Journal, 2017:1(3); 104-107.
  • 4. Yarıkkaya E, Erdoğan Durmuş Ş, Demirtaş R. Kolorektal poliplerin klinikopatolojik özellikleri: Türkiye'nin Kuzey-Doğu Anadolu Bölgesinden retrospektif bir çalışma, Balıkesir Med. Journal, 2018:2(3); 178-184.
  • 5. Suh S, Kang M, Kim MY, Chung HS, Kim SK, Hur KY. et al. Korean Type 2 Diabetes Patients have Multiple Adenomatous Polyps Compared to Non-diabetic Controls, J Korean Med Sci, 2011: 26(9); 1196–1200.
  • 6. Odze RD, Noffsinger AE. Neoplastic Diseases of the small and large intestines. In Silverberg S.G (ed) Silverberg’s Principles and Practice of Surgical Pathology and Cytopathology. China: Elsevier Inc, 2006: 1419-1464.
  • 7. Bosman FT, Carnerio F, Hruban RH et al. WHO Classification of Tumours of the Digestive System. Lyon: IARCPress. 2010: 132-73.
  • 8. Terry MB, Neugut A, Bostick A, Potter JD. Haile R, Fenoglio Preiser C. Reliability in the Classification of Advanced Colorectal Adenomas, Cancer Epidemiol Biomarkers Prev, 2002: 11; 660.
  • 9. Gundersen HJG. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in memory of William R Thomson, J Microsc, 1986: 143; 3-45.
  • 10. Cruz-Orive LM, Weibel ER. Recent stereological methods for cell biology: a brief survey, Cell Mol Psysiol, 1990: 2; 48–56.
  • 11. Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N et al. The new stereological tools: Disector, fractionator, nucleator, and point sampled intercepts and their use in pathological research and diagnosis, APMIS, 1988a; 96; 857–881.
  • 12. Canan S, Çolakoğlu S., Şahin B, Ünal B, Aslan H, Kaplan S, içinde: Cavalieri Prensibi ile Hacim Hesaplanması, Sinir Biliminde Temel Metotlar ve Stereoloji Kursu, Kurs notları 27 Ekim-6 Kasım 2006 Erzurum, sf. 1-27.
  • 13. Unbiased Stereology, Three Dimensional Measurement in Microscopy, second edition, C.V. Howard & M.G. Reed, bios scientific publishers, Oxford 1998, p. 63.
  • 14. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008, CA Cancer J Clin 2008:58; 71-96.
  • 15. Fong TV, Chuah SK, Chiou SS, Chiu KW, Hsu CC, Chiu YC, et al. Correlation of the morphology and size of colonic polyps with their histology, Chang Gung Med J, 2003: 26; 339-343.
  • 16. Cappell MS. Pathophysiology, clinical presentation, and management of colon cancer, Gastroenterol Clin North Am, 2008: 37;1-24.
  • 17. Bond J. H. Polyp guideline: diagnosis, treatment, and surveillance for patients with nonfamilial colorectal polyps. The Practice Parameters Committee of the American College of Gastroenterology, Ann. Int. Med, 1993: 119; 836-843.
  • 18. Atkin W. S., Morson B. C., Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N. Engl. J. Med. 1992;326: 658-662.
  • 19. Otchy DP, Ransohoff DF, Wolff BG, Weaver A, Ilstrup D, Carlson H et al. Metachronous colon cancer in persons who have had a large adenomatous polyp, Am. J. Gastroenterol, 1996:91; 448-454.
  • 20. Noshirwani KC., van Stolk RU, Rybicki LA, Beck GJ. Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy. Gastrointest. Endosc, 2000: 51; 433-437.
  • 21. Liu HH, Wu CM, Peng Y, Wu MS. Prevalence of advanced colonic polyps in asymptomatic, Chinese World J Gastroenterol, 2005:11(30);4731-4734.
  • 22. Pandergrass CJ, Edelstein DL, Hylind LM, Phillips BT, Donahue CI, Romans K et al. Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy study, Clin Gastroenterol Hepatol, 2008: 6(9);1011-1015.
  • 23. Elias H, Hyde D, Mullens R, Lambert FC. Colonic adenomas: stereology and growth mechanisms, Diseases of the colon & rectum, 1981: 24 (5);331-342.
  • 24. Pesce C. M, Colacino R. Relative growth of adenomatous polyps of the colon. Stereology and allometry of multiple polyposis, Virchows Arch A 1987: 412;151-154.
  • 25. Lane N, Lev R. Observations on the origin of adenomatous epithelium of the colon. Serial section studies of minute polyps in familial polyposis, Cancer, 1963: 16;751-764.
  • 26. Meijer GA, Fleege JC, Beak JP. Stereoloical assesment of architectural changes in dysplastic epithlium of colorectal adenomas, Pathol Res Pact, 1994:190(4);331-41.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm ARAŞTIRMA MAKALESİ
Yazarlar

Ferah Tuncel 0000-0001-6506-9461

Elif Demirci 0000-0002-6660-3870

Nesrin Gürsan Bu kişi benim 0000-0003-0030-7347

Yayımlanma Tarihi 28 Şubat 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 1

Kaynak Göster

APA Tuncel, F., Demirci, E., & Gürsan, N. (2021). Kolon Poliplerinin Ayırıcı Tanısında Yeni Bir Yaklaşım; Stereoloji. Balıkesir Medical Journal, 5(1), 60-71. https://doi.org/10.33716/bmedj.885281