Clinical characteristics and results of patients who underwent minor salivary gland biopsy with the suspicion of Sjogren syndrome

Yıl 2024, Cilt: 8 Sayı: 3, 129 - 137, 30.12.2024

Öznur Kutluk , Fatih Çay

https://doi.org/10.33716/bmedj.1474475

Öz

Objective: To evaluate the value and accuracy of biopsy in diagnosing Sjogren syndrome (SS) by evaluating the results of patients who underwent mınor salivary gland biopsy (MSGB) with the suspicion of SS.
Material and Methods: The study was planned with a retrospective assessment of 127 patients with a biopsy performed for SS diagnosis. The clinical and laboratory characteristics of the patients who underwent MSGB were recorded from their files. SS diagnosis was placed using the rating system according to 2016 ACR/EULAR classification criteria or based on expert opinion.
Results: 113 patients met the ınclusion criteria. 72 patients diagnosed with SS. 56 were
diagnosed according to the 2016 ACR/EULAR classification criteria and 16 were diagnosed
according to expert opinion. There were 57 patients with positive MSGB outcomes (55 SS, 2
not SS). There were 56 patients with MSGB negative outcomes (17 SS, 39 not SS). The
sensitivity of MSGB for SS diagnosis was 76.4%, and the specificity was 95.1%.
Conclusion: All of our patients had antibody test results, but the number of objective tests included in the classification criteria such as salivary flow rate and Schirmer was low. Although MSGB is considered an invasive technique, it appears to be safe technique as long as it is performed by experienced professionals. It will assist in the final decision for patients with SS suspicion and who cannot undergo other objective tests.

Anahtar Kelimeler

sjogren syndrome, diagnosis, minor salivary biopsy

Sjogren Sendromu Şüphesi ile Minör Tükürük Bezi Biyopsisi Yapılan Hastaların Klinik Özellikleri ve Sonuçları

Öz

Amaç: Sjogren sendromu şüphesi ile minör tükürük bezi biyopsisi yapılan hastaların sonuçlarının değerlendirilerek biyopsinin Sjögren sendromu (SS) tanısındaki yerini ve değerini saptamak.
Gereç ve Yöntemler: Çalışma, SS tanısı için biyopsi yapılan 127 hastanın sonuçlarının geriye dönük değerlendirilmesi ile planlandı. Minör tükürük bezi biyopsisi uygulanan hastaların klinik ve laboratuvar özellikleri dosyalarından kaydedildi. SS teşhisi, 2016 ACR/EULAR sınıflandırma kriterlerine göre veya uzman görüşüne göre konuldu.
Bulgular: 113 hasta çalışmaya dahil edilme kriterlerini karşıladı. Sjogren sendromu tanısı konulan 72 hasta vardı. 72 hastanın 56 tanesine 2016 ACR/EULAR sınıflandırma kriterlerine göre tanı konulurken, 16 tanesine uzman görüşüne göre tanı konuldu. Minör tükürük bezi biyopsi sonucu pozitif 57 (55 SS, 2SS değil), negatif 56 (17SS, 39SS değil) kişi vardı. Minör tükürük bezi biyopsisinin SS tanısı için duyarlılığı %76,4, özgüllüğü ise %95,1 idi.
Sonuç: Hastalarımızın tamamında antikor testi sonucu vardı ancak tükürük akış hızı ve Schirmer gibi sınıflandırma kriterlerinde yer alan objektif testi olan hasta sayısı düşüktü. Minör tükürük bezi biyopsisi invaziv bir teknik olarak görülse de deneyimli profesyoneller tarafından yapıldığı sürece güvenli bir teknik gibi görünmektedir. SS şüphesi olan ve diğer objektif testlerin uygulanmadığı hastalarda kesin karara varılmasında yardımcı olacaktır

Anahtar Kelimeler

sjogren sendromu,, tanı,, minör tükürük bezi biyopsisi

Kaynakça

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