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Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study

Yıl 2012, Cilt: 2012 Sayı: 3, 290 - 294, 01.03.2012
https://doi.org/10.5152/balkanmedj.2012.013

Öz

Objective: In this study, morphometric developments of the sphincter of Oddi in human fetuses were observed. Material and Methods: We observed 113 human fetuses consisting of 67 male and 46 female subjects, whose ages varied between 14 to 40 weeks who showed no signs of any pathology or anomaly externally. The common external measurements of fetuses were carried out, followed by abdominal dissection to determine where the sphincters of Oddi were localized within the duodenum and pancreas. Histological specimens of tissue samples were gathered from the inner wall of the duodenum where it was assumed that the sphincters of Oddi had been localized. The parameters of total external diameters, lumen diameters, wall thickness, diameters of ductus choledochus and ductus pancreaticus, and the distance between these two structures, which are also known as the origins of the sphincter of Oddi, were measured by using a light microscope. The standard deviations of the measurements were calculated for each gestational week and trimester. Results: The calculations suggested that there were statistically significant correlations between gestational age and all of the other parameters with the exception of the ductus choledochus (p<0.001). It was observed that the wall thickness of the ductus choledochus increased at the first half of the fetal stage and decreased at the second half, as the lumen diameter increased through the 40th week. The gender difference was not statistically significant (p>0.05). Conclusion: The data we collected in our study were considered as useful for the evaluation of the development of the sphincter of Oddi area and fetal stage. Turkish Anahtar Kelimeler: Oddi sfinkteri, insan fetusu, morfometri, mikroskobi, fetal gelişim Amaç: Çalışmamızda insan fetuslarında Oddi sfinkteri'nin fetal dönem boyunca morfometrik gelişiminin araştırılması amaçlandı. Materyal ve Metod: Çalışmaya, yaşları 14–40 gebelik haftası yaşı arasında değişen ve eksternal patolojisi veya anomalisi olmayan, toplam 113 adet insan fetusu (67 erkek, 46 kız) dahil edildi. Fetusların genel eksternal ölçümleri yapıldıktan sonra abdomen diseksiyonu ile duodenum, pankreas ve Oddi sfinkteri'nin lokalizasyonu belirlendi. Duodenum iç duvarında Oddi sfinkterinin yerleşim yerinden mikroskobik inceleme için histolojik doku örnekleri alındı. Işık mikroskobisinde; her bir fetusta Oddi sfinkterini oluşturan ductus koledocus ve ductus pankreatikus'tan total dış çap, lümen çapı, kanalların total duvar kalınlığı ve kanallar arası mesafe parametreleri ölçüldü. Her bir hafta ve trimester için ölçümlerin standart sapmaları hesaplandı. Bulgular: Ölçülen parametrelerden ductus koledocus duvar kalınlığı hariç diğer parametreler ile gestasyonel yaş arasında anlamlı korelasyon ilişkisi vardı (p<0.001). Koledok duvar kalınlığı fetal dönemin ilk yarısında artarken, ikinci yarısında koledok lümeninin genişlemesinden dolayı miada doğru giderek azalıyordu. Cinsler arasında parametreler yönünden fark bulunamadı (p>0.05). Sonuç: Çalışmamızda elde edilen verilerin, fetal dönemde, intrauterin olgularda Oddi sfinkter bölgesinin gelişiminin değerlendirilmesine katkıda bulunacağını düşünmekteyiz.

Kaynakça

  • 1. Avisse C, Flament JB, Delattre JF. Ampulla of Vater. Anatomic, embryologic, and surgical aspects. Surg Clin N Am 2000;80:201- 12. [CrossRef]
  • 2. Bosch A, Peña LR. The sphincter of oddi. Dig Dis Sci 2007;52:1211- 8. [CrossRef]
  • 3. Ishibashi Y, Murakami G, Honma T, Sato TJ, Takahashi M. Morphometric study of the sphincter of oddi (hepatopancreatic) and configuration of the submucosal portion of the sphincteric muscle mass. Clin Anat 2000;13:159-67. [CrossRef]
  • 4. Woods CM, Mawe GM, Toouli J, Saccone GT. The sphincter of Oddi: understanding its control and function. Neurogastroenterol Motil 2005;17 Suppl 1:31-40. [CrossRef]
  • 5. Ando H. Embryology of the biliary tract. Dig Surg 2010;27:87-9. [CrossRef]
  • 6. Papamiltiades M, Rettori R. Muscular structure of choledochopancreato-duodenal juncture. Acta Anat (Basel) 1957;30:575- 600. [CrossRef]
  • 7. Mahour GH, Wakim KG, Ferris DO. The common bile duct in man: its diameter and circumference. Ann Surg 1967;165:415-9. [CrossRef]
  • 8. Dowdy GS Jr, Waldron GW, Brown WG. Surgical anatomy of the pancreatobiliary ductal system. Observations. Arch Surg 1962; 84: 229-46. [CrossRef]
  • 9. Mathuna PM, White P, Clarke E, Merriman R, Lennon JR, Crowe J. Endoscopic balloon sphincteroplasty (papillary dilation) for bile duct stones: efficacy, safety, and follow-up in 100 patients. Gastrointest Endosc 1995;42:468-74. [CrossRef]
  • 10. Minami A, Nakatsu T, Uchida N, Hirabayashi S, Fukuma H, Morshed SA, et al. Papillary dilation vs sphincterotomy in endoscopic removal of bile duct stones. A randomized trial with manometric function. Dig Dis Sci 1995;40:2550-4. [CrossRef]
  • 11. Bergman JJ, Rauws EA, Fockens P, Van Berkel AM, Bossuyt PM, Tijssen JG, et al. Randomised trial of endoscopic balloon dilation versus endoscopic sphincterotomy for removal of bileduct stones. Lancet 1997;349:1124-9. [CrossRef]
  • 12. Horiguchi S, Kamisawa T. Major duodenal papilla and its normal anatomy. Dig Surg 2010;27:90-3. [CrossRef]
  • 13. Djuranovic SP, Ugljesic MB, Mijalkovic NS, Korneti VA, Kovacevic NV, Alempijevic TM, et al. Double common bile duct: a case report. World J Gastroenterol 2007;13:3770-2.
  • 14. Moore KL, Persaud TVN. The Developing Human (Clinically Oriented Embryology), 7th edn. WB Saunders Company, Philadelphia, 2003; pp 264-6.
  • 15. Howard CV, Reed MG. Unbiased Stereology, Three-Dimensional Measurement in Microscopy. BIOS Scientific Publisher, Oxford, 1998; pp 39-68.
  • 16. Koyuncu E, Malas MA, Albay S, Cankara N, Karahan N. The development of fetal pylorus during the fetal period. Surg Radiol Anat 2009;31:335-41. [CrossRef]
  • 17. Albay S, Malas MA, Koyuncu E, Evcil EH. Morphometry of the gallbladder during the fetal period. Surg Radiol Anat 2010;32:363-9. [CrossRef]
  • 18. Sadler TW. Langman’s Medical Embryology. 11th edn. Lippincott Williams & Wilkins, 2010; p 22

Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study

Yıl 2012, Cilt: 2012 Sayı: 3, 290 - 294, 01.03.2012
https://doi.org/10.5152/balkanmedj.2012.013

Öz

Kaynakça

  • 1. Avisse C, Flament JB, Delattre JF. Ampulla of Vater. Anatomic, embryologic, and surgical aspects. Surg Clin N Am 2000;80:201- 12. [CrossRef]
  • 2. Bosch A, Peña LR. The sphincter of oddi. Dig Dis Sci 2007;52:1211- 8. [CrossRef]
  • 3. Ishibashi Y, Murakami G, Honma T, Sato TJ, Takahashi M. Morphometric study of the sphincter of oddi (hepatopancreatic) and configuration of the submucosal portion of the sphincteric muscle mass. Clin Anat 2000;13:159-67. [CrossRef]
  • 4. Woods CM, Mawe GM, Toouli J, Saccone GT. The sphincter of Oddi: understanding its control and function. Neurogastroenterol Motil 2005;17 Suppl 1:31-40. [CrossRef]
  • 5. Ando H. Embryology of the biliary tract. Dig Surg 2010;27:87-9. [CrossRef]
  • 6. Papamiltiades M, Rettori R. Muscular structure of choledochopancreato-duodenal juncture. Acta Anat (Basel) 1957;30:575- 600. [CrossRef]
  • 7. Mahour GH, Wakim KG, Ferris DO. The common bile duct in man: its diameter and circumference. Ann Surg 1967;165:415-9. [CrossRef]
  • 8. Dowdy GS Jr, Waldron GW, Brown WG. Surgical anatomy of the pancreatobiliary ductal system. Observations. Arch Surg 1962; 84: 229-46. [CrossRef]
  • 9. Mathuna PM, White P, Clarke E, Merriman R, Lennon JR, Crowe J. Endoscopic balloon sphincteroplasty (papillary dilation) for bile duct stones: efficacy, safety, and follow-up in 100 patients. Gastrointest Endosc 1995;42:468-74. [CrossRef]
  • 10. Minami A, Nakatsu T, Uchida N, Hirabayashi S, Fukuma H, Morshed SA, et al. Papillary dilation vs sphincterotomy in endoscopic removal of bile duct stones. A randomized trial with manometric function. Dig Dis Sci 1995;40:2550-4. [CrossRef]
  • 11. Bergman JJ, Rauws EA, Fockens P, Van Berkel AM, Bossuyt PM, Tijssen JG, et al. Randomised trial of endoscopic balloon dilation versus endoscopic sphincterotomy for removal of bileduct stones. Lancet 1997;349:1124-9. [CrossRef]
  • 12. Horiguchi S, Kamisawa T. Major duodenal papilla and its normal anatomy. Dig Surg 2010;27:90-3. [CrossRef]
  • 13. Djuranovic SP, Ugljesic MB, Mijalkovic NS, Korneti VA, Kovacevic NV, Alempijevic TM, et al. Double common bile duct: a case report. World J Gastroenterol 2007;13:3770-2.
  • 14. Moore KL, Persaud TVN. The Developing Human (Clinically Oriented Embryology), 7th edn. WB Saunders Company, Philadelphia, 2003; pp 264-6.
  • 15. Howard CV, Reed MG. Unbiased Stereology, Three-Dimensional Measurement in Microscopy. BIOS Scientific Publisher, Oxford, 1998; pp 39-68.
  • 16. Koyuncu E, Malas MA, Albay S, Cankara N, Karahan N. The development of fetal pylorus during the fetal period. Surg Radiol Anat 2009;31:335-41. [CrossRef]
  • 17. Albay S, Malas MA, Koyuncu E, Evcil EH. Morphometry of the gallbladder during the fetal period. Surg Radiol Anat 2010;32:363-9. [CrossRef]
  • 18. Sadler TW. Langman’s Medical Embryology. 11th edn. Lippincott Williams & Wilkins, 2010; p 22
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Kadir Desdicioğlu Bu kişi benim

Kemal K. Bozkurt Bu kişi benim

Ceren Uğuz Bu kişi benim

E. Hilal Evcil Bu kişi benim

Mehmet A. Malas Bu kişi benim

Yayımlanma Tarihi 1 Mart 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 2012 Sayı: 3

Kaynak Göster

APA Desdicioğlu, K., Bozkurt, K. K., Uğuz, C., Evcil, E. H., vd. (2012). Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study. Balkan Medical Journal, 2012(3), 290-294. https://doi.org/10.5152/balkanmedj.2012.013
AMA Desdicioğlu K, Bozkurt KK, Uğuz C, Evcil EH, Malas MA. Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study. Balkan Medical Journal. Mart 2012;2012(3):290-294. doi:10.5152/balkanmedj.2012.013
Chicago Desdicioğlu, Kadir, Kemal K. Bozkurt, Ceren Uğuz, E. Hilal Evcil, ve Mehmet A. Malas. “Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study”. Balkan Medical Journal 2012, sy. 3 (Mart 2012): 290-94. https://doi.org/10.5152/balkanmedj.2012.013.
EndNote Desdicioğlu K, Bozkurt KK, Uğuz C, Evcil EH, Malas MA (01 Mart 2012) Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study. Balkan Medical Journal 2012 3 290–294.
IEEE K. Desdicioğlu, K. K. Bozkurt, C. Uğuz, E. H. Evcil, ve M. A. Malas, “Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study”, Balkan Medical Journal, c. 2012, sy. 3, ss. 290–294, 2012, doi: 10.5152/balkanmedj.2012.013.
ISNAD Desdicioğlu, Kadir vd. “Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study”. Balkan Medical Journal 2012/3 (Mart 2012), 290-294. https://doi.org/10.5152/balkanmedj.2012.013.
JAMA Desdicioğlu K, Bozkurt KK, Uğuz C, Evcil EH, Malas MA. Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study. Balkan Medical Journal. 2012;2012:290–294.
MLA Desdicioğlu, Kadir vd. “Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study”. Balkan Medical Journal, c. 2012, sy. 3, 2012, ss. 290-4, doi:10.5152/balkanmedj.2012.013.
Vancouver Desdicioğlu K, Bozkurt KK, Uğuz C, Evcil EH, Malas MA. Morphometric Development of Sphincter of Oddi in Human Fetuses During Fetal Period: Microscopic Study. Balkan Medical Journal. 2012;2012(3):290-4.