The Possible Effects of Nutrition and Microbiota on Depression

Yıl 2022, Cilt: 4 Sayı: 2, 156 - 165, 28.08.2022

Elif Nida Koç Emre Duman

https://doi.org/10.46413/boneyusbad.1105519

Öz

Depression is common mental disorder which affects more than 300 million people worldwide. Treatment of depression’s methods have low positive effect and high side effect on patients. Therefore, new treatment methods have being researched. Studies show that microbiota can affect both occurence and treatment of depression because of secretes neurotransmitter and endocrine, inflammation and immune mechanism, brain derived neurotrophic factor (BDNF), hypothalamic pituitary adrenal (HPA) axis. Nutrition, on the other hand, is an issue that should be considered because of its effect on both the microbiota and depression. Therefore, the effects of nutrition and microbiota on depression have been discussed in the light of the evidence based data.

Anahtar Kelimeler

Microbiota, Depression, Nutrition

Beslenme ve Mikrobiyotanın Depresyon Üzerine Olası Etkileri

Öz

Depresyon, dünya çapında 300 milyondan fazla insanın etkilendiği, yaygın olarak görülen bir duygu durum bozukluğudur. Depresyonu tedavi etmek için uygulanan yöntemlerin olumlu etkilerinin düşük ve yan etki oranlarının yüksek olması farklı tedavi arayışlarına yol açmaktadır. Nörotransmitter ve endokrin salgılar, inflamasyon ve bağışıklık mekanizmaları, beyinden türetilen nörotrofik faktör (BDNF) ve hipotalamus hipofiz adrenal aksı (HPA) gibi faktörler aracılığıyla bağırsak mikrobiyotası ile beyin arasındaki iletişimin depresyon oluşumu ve tedavisinde etkili olabileceği yapılan çalışmalarla ortaya konmuştur. Beslenme ise hem mikrobiyota hem de depresyon üzerindeki etkilerinden dolayı önemsenmesi gereken bir konudur. Bu nedenle beslenmenin ve mikrobiyotanın depresyon üzerine etkileri kanıta dayalı veriler ışığında tartışılmıştır.

Anahtar Kelimeler

Mikrobiyota, Depresyon, Beslenme

Kaynakça

• Al Bander, Z., Nitert, M. D., Mousa, A., Naderpoor, N. (2020). The gut microbiota and inflammation: an overview. International Journal of Environmental Research and Public Health, 17(20), 7618. doi:10.3390/ijerph17207618.
• Barandouzi, Z. A., Starkweather, A. R., Henderson, W. A., Gyamfi, A., Cong, X. S. (2020). Altered composition of gut microbiota in depression: a systematic review. Frontiers in Psychiatry, 11, 541. doi: 10.3389/fpsyt.2020.00541.
• Bear, T. L., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., Gopal, P. K. (2020). The role of the gut microbiota in dietary interventions for depression and anxiety. Advances in Nutrition, 11(4), 890-907. doi: 10.1093/advances/nmaa016.
• Du, Y., Gao, X. R., Peng, L., Ge, J. F. (2020). Crosstalk between the microbiota-gut-brain axis and depression. Heliyon, 6(6), e04097. doi: 10.1016/j.heliyon.2020.e04097.
• Evrensel, A., Tarhan, K. N. (2021). Emerging role of Gut-microbiota-brain axis in depression and therapeutic implication. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 106, 110138. doi:10.1016/j.pnpbp.2020.110138.
• Fond, G. B., Lagier, J. C., Honore, S., Lancon, C., Korchia, T., Verville, P. L. S. D., ... Boyer, L. (2020). Microbiota-orientated treatments for major depression and schizophrenia. Nutrients, 12(4), 1024. doi: 10.3390/nu12041024.
• Goh, K. K., Liu, Y. W., Kuo, P. H., Chung, Y. C. E., Lu, M. L., Chen, C. H. (2019). Effect of probiotics on depressive symptoms: A meta-analysis of human studies. Psychiatry research, 282, 112568. doi: 10.1016/j.psychres.2019.112568.
• Gu, F., Wu, Y., Liu, Y., Dou, M., Jiang, Y., Liang, H. (2020). Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota. Food & Function, 11(7), 6148-6157. doi: 10.1039/d0fo00373e.
• Hao, W. Z., Li, X. J., Zhang, P. W., Chen, J. X. (2020). A review of antibiotics, depression, and the gut microbiome. Psychiatry Research, 284, 112691. doi:10.1016/j.psychres.2019.112691.
• Hao, W. Z., Ma, Q. Y., Tao, G., Huang, J. Q., Chen, J. X. (2021). Oral coniferyl ferulate attenuated depression symptoms in mice via reshaping gut microbiota and microbial metabolism. Food & Function, 12(24), 12550-12564. doi: 10.1039/d1fo02655k.
• Hassan, A. M., Mancano, G., Kashofer, K., Fröhlich, E. E., Matak, A., Mayerhofer, R., ... Holzer, P. (2019). High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome. Nutritional Neuroscience, 22(12), 877-893. doi: 10.1080/1028415X.2018.1465713.
• Heym, N., Heasman, B. C., Hunter, K., Blanco, S. R., Wang, G. Y., Siegert, R., ... Sumich, A. L. (2019). The role of microbiota and inflammation in self-judgement and empathy: implications for understanding the brain-gut-microbiome axis in depression. Psychopharmacology, 236(5), 1459-1470. doi: 10.1007/s00213-019-05230-2.
• Hofmeister, M., Clement, F., Patten, S., Li, J., Dowsett, L. E., Farkas, B., ... Taylor, V. H. (2021). The effect of interventions targeting gut microbiota on depressive symptoms: A systematic review and meta-analysis. Canadian Medical Association Open Access Journal, 9(4), E1195-E1204. doi: 10.9778/cmajo.20200283.
• Jacka, F. N. (2017). Nutritional psychiatry: where to next?. EBioMedicine, 17, 24-29. doi: 10.1016/j.ebiom.2017.02.020. Jiang, Y., Liu, Y., Gao, M., Xue, M., Wang, Z., Liang, H. (2020). Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial activation and BDNF expression. Food & Function, 11(1), 378-391. doi: 10.1039/c9fo01780a.
• Klimova, B., Novotny, M., Valis, M. (2020). The impact of nutrition and intestinal microbiome on elderly depression—A systematic review. Nutrients, 12(3), 710. doi: 10.3390/nu12030710.
• Lach, G., Schellekens, H., Dinan, T. G., Cryan, J. F. (2018). Anxiety, depression, and the microbiome: a role for gut peptides. Neurotherapeutics, 15(1), 36-59. doi: 10.1007/s13311-017-0585-0.
• Le Morvan de Sequeira, C., Hengstberger, C., Enck, P., Mack, I. (2022). Effect of Probiotics on Psychiatric Symptoms and Central Nervous System Functions in Human Health and Disease: A Systematic Review and Meta-Analysis. Nutrients, 14(3), 621. doi: 10.3390/nu14030621.
• Leclercq, S., Le Roy, T., Furgiuele, S., Coste, V., Bindels, L. B., Leyrolle, Q., ... Delzenne, N. M. (2020). Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder. Cell Reports, 33(2), 108238. doi: 10.1016/j.celrep.2020.108238.
• Li, S., Hua, D., Wang, Q., Yang, L., Wang, X., Luo, A., Yang, C. (2020). The role of bacteria and its derived metabolites in chronic pain and depression: recent findings and research progress. International Journal of Neuropsychopharmacology, 23(1), 26-41. doi: 10.1093/ijnp/pyz061.
• Li, Y., Lv, M. R., Wei, Y. J., Sun, L., Zhang, J. X., Zhang, H. G., Li, B. (2017). Dietary patterns and depression risk: A meta-analysis. Psychiatry Research, 253, 373-382. doi: 10.1016/j.psychres.2017.04.020.
• Liu, S., Guo, R., Liu, F., Yuan, Q., Yu, Y., Ren, F. (2020). Gut microbiota regulates depression-like behavior in rats through the neuroendocrine-immune-mitochondrial pathway. Neuropsychiatric Disease and Treatment, 16, 859. doi:10.2147/NDT.S243551.
• Liu, R. T., Walsh, R. F., Sheehan, A. E. (2019). Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neuroscience & Biobehavioral Reviews, 102, 13-23. doi: 10.1016/j.neubiorev.2019.03.023.
• Louwies, T., Johnson, A. C., Orock, A., Yuan, T., Greenwood-Van Meerveld, B. (2020). The microbiota-gut-brain axis: an emerging role for the epigenome. Experimental Biology and Medicine, 245(2), 138-145. doi:10.1177/1535370219891690.
• Louzada, E. R., Ribeiro, S. M. L. (2020). Synbiotic supplementation, systemic inflammation, and symptoms of brain disorders in elders: A secondary study from a randomized clinical trial. Nutritional Neuroscience, 23(2), 93-100. doi: 10.1080/1028415X.2018.1477349.
• Lv, W. J., Liu, C., Yu, L. Z., Zhou, J. H., Li, Y., Xiong, Y., ... Guo, S. N. (2020). Melatonin alleviates neuroinflammation and metabolic disorder in DSS-induced depression rats. Oxidative Medicine and Cellular Longevity, 2020. doi: 10.1155/2020/1241894.
• Ma, S. R., Yu, J. B., Fu, J., Pan, L. B., Yu, H., Han, P., ... Wang, Y. (2021). Determination and application of nineteen monoamines in the gut microbiota targeting phenylalanine, tryptophan, and glutamic acid metabolic pathways. Molecules, 26(5), 1377. doi: 10.3390/molecules26051377.
• Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., ... Jacka, F. N. (2021). Diet and depression: exploring the biological mechanisms of action. Molecular Psychiatry, 26(1), 134-150. doi: 10.1038/s41380-020-00925-x.
• Meyyappan, A. C., Forth, E., Wallace, C. J., Milev, R. (2020). Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review. BMC Psychiatry, 20(1), 1-19. doi: 10.1186/s12888-020-02654-5.
• Molendijk, M., Molero, P., Sánchez-Pedreño, F. O., Van der Does, W., Martínez-González, M. A. (2018). Diet quality and depression risk: a systematic review and dose-response meta-analysis of prospective studies. Journal of Affective Disorders, 226, 346-354. doi: 10.1016/j.jad.2017.09.022.
• Myhrstad, M. C., Tunsjø, H., Charnock, C., Telle-Hansen, V. H. (2020). Dietary fiber, gut microbiota, and metabolic regulation—Current status in human randomized trials. Nutrients, 12(3), 859. doi:10.3390/nu12030859.
• Osimo, E. F., Baxter, L. J., Lewis, G., Jones, P. B., Khandaker, G. M. (2019). Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Psychological Medicine, 49(12), 1958-1970. doi: 10.1017/S0033291719001454.
• Park, M., Choi, J., Lee, H. J. (2020). Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptom: a randomized controlled study. Nutrients, 12(6), 1815. doi: 10.3390/nu12061815.
• Robertson, R. C., Oriach, C. S., Murphy, K., Moloney, G. M., Cryan, J. F., Dinan, T. G., ... Stanton, C. (2017). Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood. Brain, Behavior, and Immunity, 59, 21-37. doi: 10.1016/j.bbi.2016.07.145.
• Romeo, B., Blecha, L., Locatelli, K., Benyamina, A., Martelli, C. (2018). Meta-analysis and review of dopamine agonists in acute episodes of mood disorder: efficacy and safety. Journal of Psychopharmacology, 32(4), 385-396. doi: 10.1177/0269881118760661.
• Rothenberg, D. O. N., Zhang, L. (2019). Mechanisms underlying the anti-depressive effects of regular tea consumption. Nutrients, 11(6), 1361. doi: 10.3390/nu11061361.
• Rudzki, L., Stone, T. W., Maes, M., Misiak, B., Samochowiec, J., Szulc, A. (2021). Gut microbiota-derived vitamins–underrated powers of a multipotent ally in psychiatric health and disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 107, 110240. doi:10.1016/j.pnpbp.2020.110240.
• Shafiei, F., Salari-Moghaddam, A., Larijani, B., Esmaillzadeh, A. (2019). Adherence to the Mediterranean diet and risk of depression: a systematic review and updated meta-analysis of observational studies. Nutrition Reviews, 77(4), 230-239. doi: 10.1093/nutrit/nuy070.
• Simpson, C. A., Mu, A., Haslam, N., Schwartz, O. S., Simmons, J. G. (2020). Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritable bowel syndrome. Journal of Affective Disorders, 266, 429-446. doi: 10.1016/j.jad.2020.01.124.
• Sun, L., Ma, L., Zhang, H., Cao, Y., Wang, C., Hou, N., ... Nie, Y. (2019). Fto deficiency reduces anxiety-and depression-like behaviors in mice via alterations in gut microbiota. Theranostics, 9(3), 721. doi: 10.7150/thno.31562.
• Uemura, M., Hayashi, F., Ishioka, K., Ihara, K., Yasuda, K., Okazaki, K., ... Ohira, T. (2019). Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial. European Journal of Nutrition, 58(8), 3291-3302. doi: 10.1007/s00394-018-1873-0.
• Winther, G., Jørgensen, B. M. P., Elfving, B., Nielsen, D. S., Kihl, P., Lund, S., ... Wegener, G. (2015). Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour. Acta Neuropsychiatrica, 27(3), 168-176. doi: 10.1017/neu.2015.7.
• World Health Organisation. (2017). Depression and other common mental disorders: global health estimates. Geneva: World Health Organization. Erişim tarihi 25.03.2021, https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf.
• Xiao, Q., Shu, R., Wu, C., Tong, Y., Xiong, Z., Zhou, J., ... Fu, Z. (2020). Crocin-I alleviates the depression-like behaviors probably via modulating “microbiota-gut-brain” axis in mice exposed to chronic restraint stress. Journal of Affective Disorders, 276, 476-486. doi: 10.1016/j.jad.2020.07.041.
• Yuan, Z., Chen, Z., Xue, M., Zhang, J., Leng, L. (2020). Application of antidepressants in depression: A systematic review and meta-analysis. Journal of Clinical Neuroscience, 80, 169-181. doi: 10.1016/j.jocn.2020.08.013.
• Zagórska, A., Marcinkowska, M., Jamrozik, M., Wiśniowska, B., Paśko, P. (2020). From probiotics to psychobiotics–the gut-brain axis in psychiatric disorders. Beneficial Microbes, 11(8), 717-732. doi: 10.3920/BM2020.0063.
• Zhang, N., Zhang, Y., Li, M., Wang, W., Liu, Z., Xi, C., ... Zhai, S. (2020). Efficacy of probiotics on stress in healthy volunteers: a systematic review and meta‐analysis based on randomized controlled trials. Brain and Behavior, 10(9), e01699. doi: 10.1002/brb3.1699.
• Zhang, Y., Huang, R., Cheng, M., Wang, L., Chao, J., Li, J., ... Yao, H. (2019). Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome, 7(1), 1-16. doi: 10.1186/s40168-019-0733-3.