Araştırma Makalesi

ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi

Cilt: 13 Sayı: 3 15 Eylül 2023
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ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi

Öz

ABSTRACT Objective: Age-related macular degeneration (AMD) is the most common cause of advanced visual loss in developed societies. ANXA3 contributes to tumor development by affecting cell signaling pathways, cell profiling, invasion, metastasis and cell apoptosis. The aim of this study was to compare serum ANXA3 levels in wet type and dry type macular degeneration patients with the control group and to investigate whether there is a significant difference between the groups. Material and Methods: A total of 78 patients (39 patients with wet AMD, 39 patients with dry AMD diagnosed at the same time period and 39 healthy controls without any previous diagnosis of macular degeneration) were enrolled in this study. ANXA3 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: Serum ANXA3 levels were found to be significantly higher in wet AMD than in the control group (p=0.005). In addition, the difference between serum ANXA3 levels of wet and dry AMD patients was found to be significant. It was observed that there was a significant increase in wet type AMD patients (p=0.004). However, no significant difference was found in ANXA3 levels in dry type AMD compared to the control group (p=0.444). Conclusion: These findings suggest that ANXA3 protein may play an important role in age-related macular degeneration.

Anahtar Kelimeler

Kaynakça

  1. 1.Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392(10153):1147-59.
  2. 2. Abraham JR, Jaffe GJ, Kaiser PK, et al. Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Integrity. Ophthalmol Retina. 2022;6(11):1019-27.
  3. 3. Hobbs SD, Pierce K. Wet Age-Related Macular Degeneration (Wet AMD). In: StatPearls. Treasure Island (FL): StatPearls Publishing; November 7, 2022.
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  5. 5. Zhang H, Zhang Z, Guo T, et al. Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer. Front Cell Dev Biol. 2023;11:1141331.
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Ayrıntılar

Birincil Dil

Türkçe

Konular

Göz Hastalıkları ve Göz Ölçümleri (Diğer)

Bölüm

Araştırma Makalesi

Yazarlar

Ayça Taş
Türkiye

Yayımlanma Tarihi

15 Eylül 2023

Gönderilme Tarihi

1 Eylül 2023

Kabul Tarihi

15 Eylül 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 13 Sayı: 3

DOI

https://doi.org/10.16919/bozoktip.1331935

IZ

https://izlik.org/JA58FF33EC

Kaynak Göster

RIS / Bibtex
APA
Öztürk, A., Gül, M. A., Ağbektaş, T., Zontul, C., Çiftçi, C. H., Taş, A., Yalınbaş Yeter, D., & Siliğ, Y. (2023). ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi. Bozok Tıp Dergisi, 13(3), 52-57. https://doi.org/10.16919/bozoktip.1331935
AMA
1.Öztürk A, Gül MA, Ağbektaş T, vd. ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi. Bozok Tıp Dergisi. 2023;13(3):52-57. doi:10.16919/bozoktip.1331935
Chicago
Öztürk, Alpaslan, Mehmet Ali Gül, Tuğba Ağbektaş, vd. 2023. “ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi”. Bozok Tıp Dergisi 13 (3): 52-57. https://doi.org/10.16919/bozoktip.1331935.
EndNote
Öztürk A, Gül MA, Ağbektaş T, Zontul C, Çiftçi CH, Taş A, Yalınbaş Yeter D, Siliğ Y (01 Eylül 2023) ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi. Bozok Tıp Dergisi 13 3 52–57.
IEEE
[1]A. Öztürk vd., “ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi”, Bozok Tıp Dergisi, c. 13, sy 3, ss. 52–57, Eyl. 2023, doi: 10.16919/bozoktip.1331935.
ISNAD
Öztürk, Alpaslan - Gül, Mehmet Ali - Ağbektaş, Tuğba - Zontul, Cemile - Çiftçi, Cem Hakan - Taş, Ayça - Yalınbaş Yeter, Duygu - Siliğ, Yavuz. “ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi”. Bozok Tıp Dergisi 13/3 (01 Eylül 2023): 52-57. https://doi.org/10.16919/bozoktip.1331935.
JAMA
1.Öztürk A, Gül MA, Ağbektaş T, Zontul C, Çiftçi CH, Taş A, Yalınbaş Yeter D, Siliğ Y. ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi. Bozok Tıp Dergisi. 2023;13:52–57.
MLA
Öztürk, Alpaslan, vd. “ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi”. Bozok Tıp Dergisi, c. 13, sy 3, Eylül 2023, ss. 52-57, doi:10.16919/bozoktip.1331935.
Vancouver
1.Alpaslan Öztürk, Mehmet Ali Gül, Tuğba Ağbektaş, Cemile Zontul, Cem Hakan Çiftçi, Ayça Taş, Duygu Yalınbaş Yeter, Yavuz Siliğ. ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi. Bozok Tıp Dergisi. 01 Eylül 2023;13(3):52-7. doi:10.16919/bozoktip.1331935