ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki
Öz
Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasis
in patients with type 2 diabetes.
Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferative
diabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy(
PDR). Disulfide, native thiol levels (NTLs) and total thiol levels(TTLs), disulfide/NT ratio (index 1), disulfide/
TT ratio (index 2) and NT/TT ratio (index 3) of the patients were evaluated. Patients were excluded if
they had cardiovascular or cerebrovascular diseases, or a diagnosis of inflammatory diseases or malignancy,
if they were using any medications including lipid lowering agents, vitamins, or any antioxidants, or if they
had a history of alcohol intake or smoking.
Results: There was no significant difference between the groups in terms of age and gender (p=0.098 and
p=0.16, respectively). No significant difference was observed between the groups with respect to disulfide
levels (p=0.22). NTLs and TTLs were lowest in Group 1 and highest in Group 3. Significant differences
were found in NTLs and TTLs between all groups (for NTLs, p=0.01, p=0.001 and p=0.001, respectively; for
TTLs, p=0.008, p=0.001 and p=0.006, respectively). Index 1, 2 and 3 values were not significantly different
between Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observed
between Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001)
Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTL
were found to be lower as the retinopathy stage increased.
Anahtar Kelimeler
Kaynakça
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Ayrıntılar
Birincil Dil
Türkçe
Konular
Endokrinoloji
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
15 Mart 2024
Gönderilme Tarihi
1 Mart 2024
Kabul Tarihi
14 Mart 2024
Yayımlandığı Sayı
Yıl 2024 Cilt: 14 Sayı: 1
APA
Coşkun, M., Haskul, İ., Neşelioğlu, S., & Erel, Ö. (2024). ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki. Bozok Tıp Dergisi, 14(1), 40-43. https://doi.org/10.16919/bozoktip.1414942
AMA
1.Coşkun M, Haskul İ, Neşelioğlu S, Erel Ö. ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki. Bozok Tıp Dergisi. 2024;14(1):40-43. doi:10.16919/bozoktip.1414942
Chicago
Coşkun, Mehmet, İsmail Haskul, Salim Neşelioğlu, ve Özcan Erel. 2024. “ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki”. Bozok Tıp Dergisi 14 (1): 40-43. https://doi.org/10.16919/bozoktip.1414942.
EndNote
Coşkun M, Haskul İ, Neşelioğlu S, Erel Ö (01 Mart 2024) ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki. Bozok Tıp Dergisi 14 1 40–43.
IEEE
[1]M. Coşkun, İ. Haskul, S. Neşelioğlu, ve Ö. Erel, “ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki”, Bozok Tıp Dergisi, c. 14, sy 1, ss. 40–43, Mar. 2024, doi: 10.16919/bozoktip.1414942.
ISNAD
Coşkun, Mehmet - Haskul, İsmail - Neşelioğlu, Salim - Erel, Özcan. “ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki”. Bozok Tıp Dergisi 14/1 (01 Mart 2024): 40-43. https://doi.org/10.16919/bozoktip.1414942.
JAMA
1.Coşkun M, Haskul İ, Neşelioğlu S, Erel Ö. ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki. Bozok Tıp Dergisi. 2024;14:40–43.
MLA
Coşkun, Mehmet, vd. “ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki”. Bozok Tıp Dergisi, c. 14, sy 1, Mart 2024, ss. 40-43, doi:10.16919/bozoktip.1414942.
Vancouver
1.Mehmet Coşkun, İsmail Haskul, Salim Neşelioğlu, Özcan Erel. ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki. Bozok Tıp Dergisi. 01 Mart 2024;14(1):40-3. doi:10.16919/bozoktip.1414942