Araştırma Makalesi

Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ

Cilt: 14 Sayı: 2 14 Haziran 2024
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Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ

Öz

Objective: Obesity is a condition that occurs as a result of excessive weight gain. Obesity is related with the high risk of several diseases like cardiovascular diseases and diabetes mellitus. Elabela is a peptide that has emerged recently and is known to affect food intake by binding to apelinergic receptors. This study aimed to investigate the serum levels of Elabela in obese and non-obese individuals. Material and Methods: This study involved 24 people with obesity and 25 healthy adult people as control group. Height, weight, gender, age, waist-hip circumference, blood pressure of participants were recorded and routine blood tests were measured. Serum concentrations of Elabela were determined using enzyme- linked immunosorbent assay. Results: When comparing the obese group to the controls, no statistically significant differences were observed between the two groups in terms of diastolic blood pressure, blood urea nitrogen, creatinine, total cholesterol, low density lipoprotein cholesterol and C-reactive protein. Similarly, both groups did not differ statistically regarding Elabela levels. The obese group exhibited significantly elevated levels of body mass index, waist/hip ratio, systolic blood pressure values, glucose, aspartate aminotransferase, alanine aminotransferase, triglyceride, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) compared to the control group. The obese group demonstrated a significantly lower level of high-density lipoprotein cholesterol in comparison to the control group. Conclusion: In this study, it was found that there was no relationship between Elabela levels and obesity. However, this issue needs to be supported by further studies to clarify.

Anahtar Kelimeler

Kaynakça

  1. 1. Albuquerque D, Nóbrega C, Manco L, Padez C. The contribution of genetics and environment to obesity. Br Med Bull 2017;123:159–73.
  2. 2. World Obesity Day 2022 – Accelerating action to stop obesity. Available at: https://www.who.int/news/item/04-03-2022-world-obesity-day-2022-accelerating-action-to-stop-obesity. Accessed July 28, 2023.
  3. 3. Chng SC, Ho L, Tian J, Reversade B. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell 2013;27:672–80.
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  6. 6. Zhang Y, Wang Y, Lou Y, Luo M, Lu Y, Li Z, et al. Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin. Peptides (NY) 2018;109:23–32.
  7. 7. Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. J Med Chem 2016;59:2962–72.
  8. 8. Wang Z, Yu D, Wang M, Wang Q, Kouznetsova J, Yang R, et al. Elabela-apelin receptor signaling pathway is functional in mammalian systems. Sci Rep 2015;5:8170.

Ayrıntılar

Birincil Dil

Türkçe

Konular

Tıbbi Biyokimya ve Metabolomik (Diğer)

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

14 Haziran 2024

Gönderilme Tarihi

1 Haziran 2024

Kabul Tarihi

2 Haziran 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 14 Sayı: 2

DOI

https://doi.org/10.16919/bozoktip.1438185

IZ

https://izlik.org/JA68BH84GH

Kaynak Göster

RIS / Bibtex
APA
Yeniel, N., Caniklioğlu, A., Ozan, Z. T., Ercan, M., & Polat, M. F. (2024). Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi, 14(2), 85-91. https://doi.org/10.16919/bozoktip.1438185
AMA
1.Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF. Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi. 2024;14(2):85-91. doi:10.16919/bozoktip.1438185
Chicago
Yeniel, Neslihan, Ayşen Caniklioğlu, Zeynep Tuğba Ozan, Müjgan Ercan, ve Muhammet Fevzi Polat. 2024. “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”. Bozok Tıp Dergisi 14 (2): 85-91. https://doi.org/10.16919/bozoktip.1438185.
EndNote
Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF (01 Haziran 2024) Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi 14 2 85–91.
IEEE
[1]N. Yeniel, A. Caniklioğlu, Z. T. Ozan, M. Ercan, ve M. F. Polat, “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”, Bozok Tıp Dergisi, c. 14, sy 2, ss. 85–91, Haz. 2024, doi: 10.16919/bozoktip.1438185.
ISNAD
Yeniel, Neslihan - Caniklioğlu, Ayşen - Ozan, Zeynep Tuğba - Ercan, Müjgan - Polat, Muhammet Fevzi. “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”. Bozok Tıp Dergisi 14/2 (01 Haziran 2024): 85-91. https://doi.org/10.16919/bozoktip.1438185.
JAMA
1.Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF. Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi. 2024;14:85–91.
MLA
Yeniel, Neslihan, vd. “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”. Bozok Tıp Dergisi, c. 14, sy 2, Haziran 2024, ss. 85-91, doi:10.16919/bozoktip.1438185.
Vancouver
1.Neslihan Yeniel, Ayşen Caniklioğlu, Zeynep Tuğba Ozan, Müjgan Ercan, Muhammet Fevzi Polat. Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi. 01 Haziran 2024;14(2):85-91. doi:10.16919/bozoktip.1438185