COVID-19 Hastalarında Serum Nitrik Oksit Düzeylerindeki Değişiklikler

Yıl 2025, Cilt: 15 Sayı: 4, 382 - 387, 15.12.2025

Özge Nur Türkeri , Nezahat Kurt , Fatma Betül Özgeriş , Ömer Faruk Koçak , Ebubekir Bakan , Emine Parlak

https://doi.org/10.16919/bozoktip.1612733

https://izlik.org/JA82DD43UC

Öz

Amaç: Tüm dünyayı gerek sağlık gerekse ekonomik açıdan hızla olumsuz etkileyen COVID-19 pandemisinin etyolojik ajanı Coronavirüs 2 (SARS-CoV-2), beta koronavirüs ailesindendir. COVID-19 hastalarında oksidatif stres dengesizliği meydana gelmesine rağmen, değişen nitrik oksit (NO) seviyelerinin COVID-19 patogenezini nasıl etkilediği tam olarak anlaşılmamıştır. Bu amaçla COVID-19 hasta serumlarında NO düzeyleri değerlendirildi.
Gereç ve Yöntem: Çalışmaya toplam 50 yetişkin COVID-19 hastası ve 32 sağlıklı kontrol birey dahil edildi. COVID-19 hastaları ulusal kılavuzlara göre Hafif-COVID-19, Orta-COVID-19 ve Yoğun Bakım-COVID-19 olmak üzere sınıflandırıldı. Tüm hastaların serum örneklerinden NO konsantrasyonları spektrofotometrik olarak ölçüldü. Ek olarak biyokimyasal verileri toplandı.
Bulgular: Sonuç olarak NO düzeyleri hasta grupta kontrol grubuna göre düşüktü fakat bu düşüklük istatistiksel olarak anlamlı değildi (p>0.05).
Sonuç: NO düzeylerindeki değişkenlik COVID-19 hastalarında immün inflamasyon ve vasküler disfonksiyonun bir sonucu olarak ortaya çıkabileceğini düşündürtmektedir.

Anahtar Kelimeler

COVID-19 , Serbest Radikal , Nitrik Oksit

Changes in Serum Nitric Oxide Levels in COVID-19 Patients

https://izlik.org/JA82DD43UC

Öz

Aim: The etiological agent of the COVID-19 pandemic, which has rapidly negatively affected the whole world in terms of both health and economy, is Coronavirus 2 (SARS-CoV-2), a member of the beta coronavirus family. Although oxidative stress imbalance occurs in COVID-19 patients, how altered nitric oxide (NO) levels affect COVID-19 pathogenesis is not fully understood. For this purpose, NO levels were evaluated in COVID-19 patient serum sampels.
Materials and Methods: A total of 50 adult COVID-19 patients and 32 healthy control individuals were included in the study. COVID-19 patients were classified as Mild-COVID-19, Modarete-COVID-19 and ICU-COVID-19 according to national guidelines. NO concentrations were measured spectrophotometrically from the serum samples of all patients. Additionally, biochemical data were collected.
Results: As a result, NO levels were lower in the patient group compared to the control group, but this decrease was not statistically significant (p>0.05).
Conclusion: Variability in NO levels suggests that it may occur as a result of immune-inflammation and vascular dysfunction in COVID-19 patients.

Anahtar Kelimeler

COVID-19; , Free Radical; , Nitric Oxide

Etik Beyan

Ethical approval was obtained from Clinical Research Ethics Committee of Atatürk University School of Medicine (Approval number: 24.06.2021). This study was accepted with the number B.30.2.ATA.0.01.00/369

Kaynakça

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