Akut Dekompanse Kalp Yetersizliği Olan Hastalarda Prognostik Belirteçlerin Tanımlanması

Öz

Amaç: Bu çalışmada akut dekompanse kalp yetmezliği (ADKY) tanısıyla hastaneye yatırılan hastalarda 90 günlük mortaliteyi öngörmede prognostik belirteçlerin etkinliği değerlendirildi. Gereç ve Yöntemler: Bu retrospektif çalışmada 01.05.2023 ile 01.09.2024 tarihleri arasında hastaneye yatırılan 559 ADHF hastasının verileri analiz edildi. Yaş, cinsiyet, laboratuvar parametreleri ve 90 günlük mortalite verileri toplandı ve mortaliteyi etkileyen bağımsız değişkenler lojistik regresyon ve alıcı işletim karakteristiği (ROC) analizi ile değerlendirildi. Bulgular: Yaş, kan üre azotu, albümin ve laktat düzeyleri 90 günlük mortalitenin bağımsız belirleyicileri olarak tanımlandı. Kan üre nitrojen düzeyi, 30.9 mg/dL kesme değeri için en yüksek eğri altında kalan alanı (AUC = 0.673) göstermiştir. Laktat düzeyi >1,45 mmol/L olan hastalarda mortalite riskinde anlamlı bir artış gözlenmiştir. Sonuçlar: Yaş, kan üre azotu, albümin ve laktat düzeyleri ADHF hastalarında 90 günlük mortalite için güçlü prognostik belirteçlerdir. Bu bulgular erken risk tabakalandırmasına ve kişiselleştirilmiş tedavi stratejilerinin geliştirilmesine katkıda bulunabilir.

Anahtar Kelimeler

• Albümin
• BUN
• Kalp yetersizliği
• Laktat
• Mortalite
• Yaş

Identification of Prognostic Markers in Patients with Acute Decompensated Heart Failure

Öz

Purpose: This study aims to evaluate the effectiveness of prognostic markers in predicting 90-day mortality in patients admitted to the hospital with a diagnosis of acute decompensated heart failure (ADHF). Materials and Methods: This retrospective study analyzed data from 559 ADHF patients admitted between 01.05.2023 and 01.09.2024. Age, sex, laboratory parameters, and 90-day mortality data were collected, and independent variables affecting mortality were evaluated via logistic regression and receiver operating characteristic (ROC) analysis. Results: Age, blood urea nitrogen, albumin, and lactate levels were identified as independent predictors of 90-day mortality. The blood urea nitrogen level demonstrated the highest area under the curve (AUC = 0.673) for a cutoff value of 30.9 mg/dL. A significant increase in mortality risk was observed for patients with lactate levels >1.45 mmol/L. Conclusion: Age, blood urea nitrogen, albumin, and lactate levels are strong prognostic markers for 90-day mortality in patients with ADHF. These findings may contribute to early risk stratification and the development of personalized treatment strategies.

Anahtar Kelimeler

• Albumin
• BUN
• Heart failure
• Lactate
• Mortality
• Age

Kaynakça

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