Rozase Hastalarında Antinükleer Antikor ve İnflamatuar Belirteçlerin Değerlendirilmesi

Yıl 2026, Cilt: 16 Sayı: 1, 32 - 36, 15.03.2026

Didem Kazan , Burcu Bahar İnci

https://doi.org/10.16919/bozoktip.1780348

https://izlik.org/JA59DF88TZ

Öz

Amaç:
Rosacea, sistemik inflamatuar ve otoimmün hastalıklarla ilişki potansiyeli olan kronik inflamatuar bir cilt hastalığıdır. Bu çalışmada, rosacea hastalarında antinükleer antikor (ANA) ve kompleman düzeyleri dâhil olmak üzere inflamatuar belirteçlerin incelenmesi amaçlanmıştır.
Gereç ve Yöntem:
Mart 2022 ile Mart 2023 tarihleri arasında rosacea tanısı alan, 18 yaş ve üzeri 178 hasta retrospektif olarak değerlendirildi. Yaş ve cinsiyet açısından eşleştirilmiş 49 sağlıklı birey kontrol grubunu oluşturdu. Katılımcıların demografik bilgileri ile lökosit ve trombosit sayısı, hemoglobin, hematokrit, eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), kompleman C3 ve C4 düzeyleri ve ANA titresi gibi laboratuvar verileri kaydedildi ve analiz edildi.
Bulgular:
Rosacea hastalarının %7,9’unda (14/178) ANA pozitifliği saptandı. Lökosit (p=0,482), trombosit (p=0,567), hemoglobin (p=0,828), hematokrit (p=0,877), ANA titresi (p=0,946), C3 (p=0,665), ESH (p=0,083) ve CRP (p=0,690) değerleri açısından hasta ve kontrol grupları arasında anlamlı fark bulunmadı. Ancak, rosacea hastalarında serum C4 düzeyleri kontrol grubuna göre anlamlı şekilde düşük bulundu (p=0,029).
Sonuç:
Rosacea hastalarında serum C4 düzeylerinde azalma gözlenmiş olup, bu durum sistemik inflamatuar veya otoimmün süreçlerle olası bir ilişkiye işaret edebilir. Bulguların klinik öneminin daha iyi anlaşılması için ileriye dönük çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

rosacea , inflamasyon , otoimmün hastalık

Etik Beyan

Çalışma etik kurallara uygun olarak yapılmıştır.

Destekleyen Kurum

yok

Teşekkür

yok

The Frequency Of Antinuclear Antibody Positivity And Inflammatory Indicators Elevation In Rosacea Patients

https://izlik.org/JA59DF88TZ

Öz

Objective: Rosacea, a chronic inflammatory disease, has been the subject of previous studies due to its potential link with inflammatory and autoimmune diseases.
Materials and methods: In this retrospective, case-control study, patients older than 18, diagnosed with rosacea, and gender- and age-matched healthy controls were included in the study between March 2022 and 2023. We thoroughly evaluated the patients' demographic, clinical features, and inflammatory indicator laboratory tests, including leucocyte, platelet, hemoglobin, hematocrit levels, sedimentation (ESR), C-reactive protein (CRP), complement- 3 (C3), complement- 4 (C4) and antinuclear antibody (ANA) titers.
Results: 178 patients with rosacea and 49 healthy controls were participated in the study. ANA positivity was 7.9% (14/178) in rosacea patients. There was no statistically significant difference between the two groups in terms of mean total leucocyte, platelet, hemoglobin, hematocrit, ANA, C3, and CRP levels (p=0.771; p=0,835; p=0,216; p=0,193; p=0;945; p=0.511; p= 0.435, respectively). However, ESR levels were significantly higher and serum C4 levels were significantly lower in rosacea patients (p=0.030; p=0.003, respectively).
Conclusion: Patients with rosacea may exhibit antinuclear antibody positivity, elevated ESR levels, and decreased serum C4 levels. Further studies are needed to provide more clarity on this issue.

Anahtar Kelimeler

rosacea , inflammation , autoimmune disease

Etik Beyan

This study was conducted in accordance with ethical guidelines.

Destekleyen Kurum

none

Teşekkür

none

Kaynakça

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