İnme Hastalarında Nöropatik Ağrı ile Serum Magnezyum Düzeyleri Arasındaki İlişkinin Değerlendirilmesi

Öz

Amaç: Bu çalışma, inme sonrası hastalarda nöropatik ağrı ile serum magnezyum düzeyleri arasındaki ilişkiyi araştırmıştır. Gereç ve Yöntemler: Akut dönemi tamamlamış ve rehabilitasyon için uygun hastalar çalışmaya dâhil edilmiştir. Katılımcıların sosyodemografik ve klinik özellikleri, eşlik eden hastalıkları ve ilaç kullanımları kaydedilmiştir. Nöropatik ağrı Douleur Neuropathique 4 (DN4) anketiyle; motor ve yürüme fonksiyonları ise sırasıyla Brunnstrom Evreleri ve Fonksiyonel Ambulasyon Sınıflaması (FAS) ile değerlendirilmiştir. Değerlendirmeler, başlangıçta ve dört haftalık rehabilitasyon programı sonrasında tekrarlanmıştır. Bulgular: Analize alınan 110 hastanın %74,5’i iskemik inme geçirmiş olup, inme başlangıcından itibaren medyan süre 6 aydı (IQR: 4–12,8). Tedavi sonrası Brunnstrom evreleri ve FAS skorlarında anlamlı artış (tümü p<0,001), DN4 skorlarında ise azalma saptandı (ortanca (3 (1-5)’den 2 (0-3)’ye, p<0.001). Serum magnezyum düzeyi, tedavi sonrası DN4 skorlarıyla negatif (ρ = –0,219, p=0,022) ve motor ile fonksiyonel göstergelerle pozitif korelasyon gösterdi (sırasıyla ρ = 0,274, 0,271 ve 0,210, p<0,05). Sonuç: Bulgular, düşük serum magnezyum düzeylerinin artmış nöropatik ağrı ve daha zayıf fonksiyonel iyileşmeyle ilişkili olabileceğini göstermektedir. Magnezyumun inme sonrası ağrı ve iyileşme üzerindeki rolünü aydınlatmak için ileriye dönük çalışmalar gereklidir.

Anahtar Kelimeler

• Ağrı
• İnme
• İnme Rehabilitasyonu
• Nöropatik Ağrı
• Magnezyum

The Relationship Between Neuropathic Pain and Serum Magnesium Levels in Stroke Patients

Öz

Objective: This study aimed to investigate the relationship between neuropathic pain and serum magnesium levels in post-stroke patients. Material and Methods: Consecutive patients who had completed the acute phase and were eligible for rehabilitation were included. Sociodemographic and clinical data, comorbidities, and medications were recorded at baseline. Neuropathic pain was assessed using the Douleur Neuropathique 4 (DN4) questionnaire, and motor and gait functions were evaluated using the Brunnstrom Recovery Stages and Functional Ambulation Classification (FAC). Assessments were repeated after a four-week rehabilitation program. Results: A total of 110 patients (74.5% ischemic stroke) were analyzed, with a median time since onset of 6 months (IQR: 4–12.8). Brunnstrom stages and FAC scores significantly improved post-treatment (all p<0.001), while DN4 scores decreased (median (3 (1-5) vs. 2 (0-3), p<0.001). Baseline serum magnesium was negatively correlated with post-treatment DN4 scores (ρ = –0.219, p=0.022) and positively correlated with baseline and post-treatment FAC and upper-limb Brunnstrom stages (ρ = 0.274, 0.271 and 0.210, respectively, p<0.05 for all). Conclusion: These findings suggest that lower serum magnesium concentrations are associated with greater neuropathic pain and poorer functional recovery after stroke rehabilitation. Further prospective studies are needed to elucidate the role of magnesium in post-stroke pain modulation and motor recovery.

Anahtar Kelimeler

• Pain
• Stroke
• Stroke Rehabilitation
• Neuropathic Pain
• Magnesium

Kaynakça

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