Evaluation of Myonectin and Irisin Levels in Pregnant and Non-Pregnant Women

Yıl 2026, Cilt: 16 Sayı: 1, 56 - 64, 15.03.2026

Melike Demir Çaltekin

https://doi.org/10.16919/bozoktip.1839161

https://izlik.org/JA85WC82AX

Öz

Objective: To compare serum myonectin and irisin levels between healthy pregnant and non-pregnant women, and to evaluate their relationship with metabolic parameters.
Materials and Methods: We conducted a cross-sectional study including 40 pregnant women in their second trimester (between 14 and 28 weeks of gestation) (case group) and 45 healthy non-pregnant women (control group). Fasting blood samples were analyzed for myonectin, irisin, glucose, insulin, and lipid profile. Myonectin and irisin were measured by ELISA. Statistical analyses were performed using SPSS v28, with group comparisons by t-test/Mann–Whitney U, correlations by Spearman’s rho, and diagnostic performance by receiver operating characteristic (ROC) curves.
Results: Pregnant women had significantly lower fasting glucose but higher total cholesterol, triglycerides, LDL-C, and HDL-C levels than controls (p<0.05 for all). Serum myonectin and irisin were significantly higher in the pregnant group (p=0.012 and p<0.001, respectively). Myonectin levels correlated negatively with fasting glucose (r=–0.225, p=0.038) and positively with triglycerides (r=0.381, p<0.001). Irisin showed positive correlations with total cholesterol (r=0.348, p=0.001) and triglycerides (r=0.421, p<0.001). In ROC analysis, the discriminatory AUC values for myonectin and irisin levels in pregnancy were found to be 0.689 and 0.806, respectively.
Conclusion: Healthy pregnancy is associated with elevated serum myonectin and irisin levels, which correlate with maternal lipid and glucose parameters. These myokines may play an adaptive role in gestational metabolic changes and could serve as metabolic biomarkers in pregnancy.

Anahtar Kelimeler

Miyonectin , Irisin , Myokines , Pregnancy

Etik Beyan

The study protocol was approved by the Ordu University Scientific Research Ethics Committee, with the decision number 2024/103.

Destekleyen Kurum

The author received no financial support for the research and/or authorship of this article.

Teşekkür

None.

Gebelerde ve Gebe Olmayan Kadınlarda Myonektin ve İrisin Düzeylerinin Değerlendirilmesi

https://izlik.org/JA85WC82AX

Öz

Amaç: Sağlıklı gebeler ile gebe olmayan kadınlarda serum miyonektin ve irisin düzeylerinin farklı olup olmadığını araştırmak ve bu miyokinlerin metabolik parametrelerle ilişkisini değerlendirmektir.
Gereç ve Yöntem: Kesitsel bir çalışma kapsamında ikinci trimesterde (gebeliğin 14. ve 28. haftaları arasında) olan 40 hamile kadın (vaka grubu) ve 45 sağlıklı hamile olmayan kadın incelendi. Açlık kan örneklerinde miyonektin, irisin, glukoz, insülin ve lipid profili analiz edildi. Miyonektin ve irisin düzeyleri ELISA yöntemiyle ölçüldü. İstatistiksel analizler SPSS v28 ile yapıldı; gruplar Student t testi veya Mann–Whitney U testi ile karşılaştırıldı, korelasyonlar Spearman analiziyle değerlendirildi ve tanısal performans ROC eğrisi ile incelendi.
Bulgular: Gebe grubunda açlık glukozu anlamlı derecede daha düşük, total kolesterol, trigliserid, LDL-K ve HDL-K düzeyleri kontrol grubuna göre daha yüksek bulundu (tümü için p<0.05). Gebelerde serum miyonektin ve irisin düzeyleri kontrol grubundan anlamlı olarak daha yüksekti (sırasıyla p=0.012 ve p<0.001). Miyonektin düzeyi açlık glukoz ile negatif (r=–0.225, p=0.038), trigliserid ile pozitif korelasyon gösterdi (r=0.381, p<0.001). İrisin düzeyi total kolesterol (r=0.348, p=0.001) ve trigliserid (r=0.421, p<0.001) ile pozitif koreleydi. ROC analizinde, miyonektin ve irisin düzeylerinin gebelikte ayırt edici AUC değerleri sırasıyla 0.689 ve 0.806 olarak bulundu.
Sonuç: Sağlıklı gebelikte serum miyonektin ve irisin düzeyleri, gebe olmayanlara kıyasla yüksektir ve bu miyokin düzeyleri maternal lipid ve glukoz parametreleriyle ilişkilidir. Bu durum, miyonektin ve irisinin gebelikteki metabolik adaptasyonda rol oynayabileceğini ve gebeliğin metabolik durumunu yansıtan biyobelirteçler olabileceğini düşündürmektedir.

Anahtar Kelimeler

Miyonektin , İrisin , Myokinler , Gebelik

Etik Beyan

Çalışma protokolü, Ordu Üniversitesi Bilimsel Araştırma Etik Kurulu tarafından 2024/103 sayılı karar ile onaylanmıştır.

Destekleyen Kurum

Yazar, bu makalenin araştırması ve/veya yazımı için herhangi bir mali destek almamıştır.

Teşekkür

Yoktur.

Kaynakça

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