Klinik Evre T1 Böbrek Tümörlerinde Benign Histoloji Sıklığı ve İlişkili Faktörlerin İncelenmesi

Öz

Amaç: Çapı <7 cm (T1) olan renal kitlelerde preoperatif parametrelerin benign patoloji ile ilişkisini karşılaştırmak.

Gereç ve Yöntemler: Ocak 2007 ile Haziran 2016 arasında Ankara Şehir Etlik Hastanesi’nde çapı <7 cm (T1) olan renal kitleler nedeniyle radikal nefrektomi (RN) veya parsiyel nefrektomi (PN) uygulanan hastalar retrospektif olarak değerlendirildi. Yaş, cinsiyet, sigara öyküsü, komorbiditeler (diabetes mellitus, hipertansiyon, dislipidemi, obezite), başvuru semptom veya bulguları (hematüri, kilo kaybı, hipertansiyon), tümör boyutu, yerleşimi, tarafı, büyüme paterni (endofitik/ekzofitik) ve karakteri (kistik/solid) dahil olmak üzere veriler toplandı.

Bulgular: Toplamda 243 hastaya renal tümör nedeniyle cerrahi uygulandı. Bunların 58’inde (%23,8) benign, 185’inde (%76,2) malign tümör histopatolojisi vardı. Benign tümör grubunda kadın cinsiyet (%63,8) anlamlı olarak daha yüksekti (p=0,004). Yaş, tümör boyutu, sigara öyküsü ve komorbiditeler, taraf (sol/sağ), başvuru semptomları, tümör yerleşimi (üst/orta/alt pol), büyüme paterni (endofitik/ekzofitik) ve karakteri (kistik/ solid) açısından gruplar arasında anlamlı fark gözlenmedi ve patolojik sonuçlar üzerinde anlamlı bir etkisi olmadığı görüldü (p>0,05).

Sonuç: Çalışmamızda küçük renal tümörlerde kadın cinsiyet benign histopatoloji ile ilişkili bulundu. Sonuç olarak, küçük renal kitlelerde benign patoloji oranının yüksek olması nedeniyle cerrahi öncesi prediktörler dikkate alınabilir.

Anahtar Kelimeler

• Renal Hücreli Karsinom
• Böbrek Kanseri
• Nefrektomi
• Benign Neoplazmlar

Etik Beyan

Çalışma, Helsinki Bildirgesi’ne (2013 yılında revize edildiği şekliyle) uygun olarak yürütülmüştür. Çalışma, Ankara Etlik Şehir Hastanesi No. 1 Klinik Araştırmalar Etik Kurulu tarafından onaylanmıştır (Onay No: AEŞH-EK1-2023-320) ve bu retrospektif analiz için bireysel onamdan feragat edilmiştir.

INVESTIGATION OF THE RATE OF BENIGN HISTOLOGY AND RELATED FACTORS IN CLINICAL STAGE T1 KIDNEY TUMORS

Öz

Objectives: To compare the relationship between a benign pathology of preoperative parameters of renal masses <7cm (T1) in diameter. To evaluate the prevalence and identify predictors of benign histopathology in renal masses smaller than 7 cm (T1 stage).

Materials and Methods: Patients who underwent radical nephrectomy (RN) or partial nephrectomy (PN) for renal masses < 7 cm (T1) at Ankara City Etlik Hospital, between January 2007 and June 2016 were evaluated retrospectively. Data including age, gender, smoking history, comorbidities (diabetes mellitus, hypertension, dyslipidemia, obesity), presentation symptoms or signs (hematuria, weight loss, hypertension), tumor size, location, laterality, the pattern of growth (endophytic/exophytic) and character (cystic/ solid) were collected.

Results: Overall, 243 patients underwent surgery for a renal tumor. Among these, 58 (23.8%) had benign, and 185 (76.2%) had malignant tumor histopathology. Female sex (63.8%) was significantly higher in the benign tumor group (p=0.004). There was no significant difference between the groups regarding age, tumor size, smoking history and comorbidities, laterality (left/right), presentation symptoms, tumor location (upper/middle/lower pole), the pattern of growth (endophytic/exophytic) and character (cystic/ solid) were observed pathological results to impact not significantly (p>0.05). No significant differences were observed between the groups in terms of age, tumor size, smoking history, comorbidities, laterality, presentation symptoms, tumor location, growth pattern, or tumor characteristics (p>0.05).

Conclusion: In our study, the female gender was associated with benign histopathology in small renal tumors. As a result, predictors before surgery may be considered due to the high rate of benign pathology of small renal masses.

Anahtar Kelimeler

• Renal Cell Carcinoma
• Cancer of Kidney
• Nephrectomy
• Benign Neoplasms

Etik Beyan

Ethics approval The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by Committee of Ankara Etlik City Hospital No. 1 Clinical Research Ethics Committee (Approval No. AEŞH-EK1-2023-320.) and individual consent for this retrospective analysis was waived.

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