UYKU APNE SENDROMU VE ENDOKRİNOLOJİ Sleep Apne Syndrome and Endocrinology

Yıl 2018, Uyku Hastalıkları Özel Sayı, 53 - 57, 27.04.2018

Elif Turan Yalçın Aral

Öz

ÖZET

Obstrüktif uyku apne sendromu (OUAS), uyku esnasında solunum durması sonucu oluşan

yaygın görülen bir hastalıktır. Uykuda oluşan solunum bozuklukları neticesinde vücutta çeşitli

metabolik değişiklikler de meydana gelmektedir. Ayrıca bazı metabolik bozukluklar da uykuda

solunum bozukluğu oluşumunu kolaylaştırmaktadır. Bu sebeple OUAS ile endokrinolojik, kardiyovasküler

ve pulmoner bazı hastalıklar zaman zaman birliktelik göstermektedir.

Anahtar Sözcükler: Obstrüktif uyku apne sendromu; Obezite; Glukoz intoleransı; Hipotiroidi.

ABSTRACT

Obstructive sleep apnea syndrome (OSAS) is a common disease that occurs as a result of

respiratory pause during sleep. As a result of sleep related breathing disorders, various

metabolic changes occur in the body. In addition; some metabolic disorders also facilitate

sleep disordered breathing. For this reason, endocrinological, cardiovascular and pulmonary

diseases occasionally coexist with OSAS.

Keywords: OSAS; Obesity; Glucose intolerance; Hypothyroidism

Anahtar Kelimeler

UYKU APNE SENDROMU VE ENDOKRİNOLOJİ Sleep Apne Syndrome and Endocrinology

Kaynakça

• 1. Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, et al. Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. The Journal of clinical endocrinology and metabolism. 2002 Jul;87(7):3394-8. 2. Penev PD. Association between sleep and morning testosterone levels in older men. Sleep. 2007 Apr;30(4):427-32. 3. Gambineri A, Pelusi C, Pasquali R. Testosterone levels in obese male patients with obstructive sleep apnea syndrome: relation to oxygen desaturation, body weight, fat distribution and the metabolic parameters. Journal of endocrinological investigation. 2003 Jun;26(6):493-8. 4. Meston N, Davies RJ, Mullins R, Jenkinson C, Wass JA, Stradling JR. Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. Journal of internal medicine. 2003 Nov;254(5):447-54. 5. Netzer NC, Eliasson AH, Strohl KP. Women with sleep apnea have lower levels of sex hormones. Sleep & breathing = Schlaf & Atmung. 2003 Mar;7(1):25-9. 6. Lanfranco F, Gianotti L, Pivetti S, Navone F, Rossetto R, Tassone F, et al. Obese patients with obstructive sleep apnoea syndrome show a peculiar alteration of the corticotroph but not of the thyrotroph and lactotroph function. Clinical endocrinology. 2004 Jan;60(1):41-8. 7. Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obesity surgery. 2003 Oct;13(5):676-83. 8. O’Keeffe T, Patterson EJ. Evidence supporting routine polysomnography before bariatric surgery. Obesity surgery. 2004 Jan;14(1):23-6. 9. Schwartz AR, Patil SP, Laffan AM, Polotsky V, Schneider H, Smith PL. Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proceedings of the American Thoracic Society. 2008 Feb 15;5(2):185-92. 10. Dacal Quintas R, Tumbeiro Novoa M, Alves Perez MT, Santalla Martinez ML, Acuna Fernandez A, Marcos Velazquez P. Obstructive sleep apnea in normal weight patients: characteristics and comparison with overweight and obese patients. Archivos de bronconeumologia. 2013 Dec;49(12):513-7.