Postoperatif ağrı kontrolünde preemptif tek doz uygulanan deksketoprofen trometamol ile deksmedetomidinin etkinliklerinin karşılaştrılması

Yıl 2015, Cilt: 5 Sayı: 2, 0 - 0, 01.06.2015

Selda Kayaaltı Fatih Uğur Mehmet Dolanbay Recep Aksu Seher Orbay Yaşlı

Öz

Amaç: Bu çalışmada; abdominal histerektomi uygulanacak hastalarda postoperatif ağrı tedavisinde preemptif intravenöz (ıv) deksketorofen trometamol ile deksmedetomidinin analjezik etkilerininin karşılaştırılması amaçlanmıştır.

Materyal ve Metod: Kurumsal onay ve izin alındıktan sonra yaşları 18-65 yaş arasında, ASA I-II, abdominal histerektomi uygulanacak olan 60 hasta randomize olarak 30’arlı iki eşit gruba ayrılmıştır. Hastalara anestezi indüksiyonundan sonra, cerrahi insizyondan 10 dk önce deksketoprofen 50 mg (Grup I) veya deksmedetomidin 1µg/kg (Group II) iv uygulandı. Postoperatif dönemde morfin kullanılarak Hasta Kontrollü Analjezi (HKA) sağlandı. Hemodinamik parametreler, Visüel Analog Skala (VAS) ile ağrı ölçümü, sedayon skoru, morfin tüketimi ve olası yan etkiler postoperatif 2, 6, 12 ve 24. saatlerde kaydedildi.

Bulgular: Postoperatif 24 saatlik dönemde; ağrı skorları VAS ile değerlendirilen gruplar arasında VAS ağrı skorları benzer olarak bulunmuştur (p>0.05). Toplam 24 saatlik morfin tüketimi Grup I ve II için sırasıyla 21,9 ± 13,9 ve 19,6 ± 12,2 mg dı (p>0.05). Yan etkiler açısından da gruplar arasında anlamlı farklılık bulunmadı (p>0.05).

Sonuç: Bu çalışma ile deksketoprofen trometamol ve deksmedetomidinin preemptif analjezik etkinlikleri benzer bulunmuştur. Aynı zamanda yan etki açısından da deksketoprofen trometamol ile deksmedetomidin arasında anlamlı bir farklılık bulunmamıştır.

Kaynakça

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