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Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester

Yıl 2019, Cilt: 9 Sayı: 2, 42 - 47, 28.06.2019

Öz

Objective: Vitamin B12 (cobalamin) and folate are essential micronutrient for cellular growth and
differentiation. In current sequential study, our aim is to determine the mean B12 and folate levels and
prevalence of B12 and folate deficiency at each trimester in Turkish healthy pregnant women who did not
use any supplementation.
Method: A prospective cross-sectional study was conducted between January-2016 and May-2017.
Singleton pregnancies in the first trimester, not using any vitamin supplementation were included. Blood
samples were collected at 10-14, 20-24 and at last 30-34 gestational weeks and vitamin B12, folate and
homocystein levels were calculated.
Results: In first trimester, we found out that 2.44%, in second trimester 2.41% and in third trimester 2.27%
of patients had vitamin B12 deficiency (B12<126.5 pg/mL). There was statistically significant decrease in
folate and homocystein levels in the second trimester compare to first trimester (p<0.001).
Conclusion: The homocysteine level was found similar in the third compared to first trimester with a gradual
increase from the second trimester value, this could be explained with the decrease in the B12 level in the
third trimester. By the way, deficiency rates for B12 and folate were rare in Turkey after new health policy
compared to other countries even without supplementation.

Kaynakça

  • 1. Saravanan P YC. Role of maternal vitamin B12 on the metabolic health of the offspring: a contributor to the diabetes epidemic? Br J Diabetes Vasc Dis. 2010;10:109-14. 2. Smith AD KY-I, Refsum H. Is folic acid good for everyone? Am J Clin Nutr. 2008;87:517-33. 3. Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr. 2004;24:299-326. PubMed PMID: 15189123. Epub 2004/06/11. eng. 4. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998 Nov;55(11):1449-55. PubMed PMID: 9823829. Epub 1998/11/21. eng. 5. Refsum H, Smith AD. Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):959-61. PubMed PMID: 12810791. Pubmed Central PMCID: 1738528. Epub 2003/06/18. eng. 6. George L, Mills JL, Johansson AL, Nordmark A, Olander B, Granath F, et al. Plasma folate levels and risk of spontaneous abortion. JAMA. 2002 Oct 16;288(15):1867-73. PubMed PMID: 12377085. Epub 2002/10/17. eng. 7. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine,folic Acid and vitamin b(12) in patients with preeclampsia. Indian J Clin Biochem. 2011 Jul;26(3):257-60. PubMed PMID: 22754189. Pubmed Central PMCID: 3162959. Epub 2012/07/04. eng. 8. Sanchez SE, Zhang C, Rene Malinow M, Ware-Jauregui S, Larrabure G, Williams MA. Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol. 2001 Mar 1;153(5):474-80. PubMed PMID: 11226979. Epub 2001/02/28. eng. 9. Ronnenberg AG, Goldman MB, Chen D, Aitken IW, Willett WC, Selhub J, et al. Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr. 2002 Dec;76(6):1385-91. PubMed PMID: 12450907. Epub 2002/11/27. eng. 10. Krishnaveni GV, Hill JC, Veena SR, Bhat DS, Wills AK, Karat CL, et al. Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes. Diabetologia. 2009 Nov;52(11):2350-8. PubMed PMID: 19707742. Pubmed Central PMCID: 3541499. Epub 2009/08/27. eng.

TÜRK GEBE POPÜLASYONUNDA 1.2.3. TRİMESTER’DEKİ VIT B12, FOLAT VE HOMOSİSTEİN DÜZEYLERİNİN DEĞERLENDİRİLMESİ

Yıl 2019, Cilt: 9 Sayı: 2, 42 - 47, 28.06.2019

Öz

Amaç: Vitamin B12 ve folat, hücre büyümesi ve farklılaşması için esansiyel mikronutrientlerdir. Bu kesitsel
çalışmadaki amacımız, vitamin desteği almayan sağlıklı Türk gebe kadınlardaki vitamin B12 ve folat ortalamalarını ve eksiklik prevelanslarını tespit etmektir.
Method: Bu prospektif kesitsel çalışma Ocak 2016- Mayıs 2017 tarihleri arasında gerçekleşmiştir. Birinci
trimesterdeki, vitamin desteği almayan, tekil gebelikler çalışmaya dahil edilmiştir. 10-14, 20-24 ve son olarak 30-34 gestasyonel haftalarda kan örnekleri hastalardan toplanmış ve vitamin B12, folat ve homosistein
seviyeleri hesaplanmıştır.
Sonuç: Vitamin B12 eksikliği (B12<126.5 pg/mL), birinci trimesterde %2.44, ikinci trimesterde %2.41 ve
üçüncü trimesterde %2.27 gebede tespit edilmiştir. Folat ve homosistein seviyelerinde ikinci trimesterde ilk
trimestere göre istatistiki olarak anlamlı düşüş saptanmıştır (p<0.001).
Tartışma: Homosistein seviyesi üçüncü trimesterde ilk trimesterle benzer olmasına rağmen, ikinci trimester
göre hafif bir artış göstermiştir. Sonuç olarak, vitamin desteği bulunmamasına rağmen Türkiye’de yeni sağlık
sistemi politikası ile Vitamin B12 ve folat eksikliği diğer ülkeler ile kıyasla belirgin az olarak bulunmuştur.

Kaynakça

  • 1. Saravanan P YC. Role of maternal vitamin B12 on the metabolic health of the offspring: a contributor to the diabetes epidemic? Br J Diabetes Vasc Dis. 2010;10:109-14. 2. Smith AD KY-I, Refsum H. Is folic acid good for everyone? Am J Clin Nutr. 2008;87:517-33. 3. Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr. 2004;24:299-326. PubMed PMID: 15189123. Epub 2004/06/11. eng. 4. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998 Nov;55(11):1449-55. PubMed PMID: 9823829. Epub 1998/11/21. eng. 5. Refsum H, Smith AD. Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):959-61. PubMed PMID: 12810791. Pubmed Central PMCID: 1738528. Epub 2003/06/18. eng. 6. George L, Mills JL, Johansson AL, Nordmark A, Olander B, Granath F, et al. Plasma folate levels and risk of spontaneous abortion. JAMA. 2002 Oct 16;288(15):1867-73. PubMed PMID: 12377085. Epub 2002/10/17. eng. 7. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine,folic Acid and vitamin b(12) in patients with preeclampsia. Indian J Clin Biochem. 2011 Jul;26(3):257-60. PubMed PMID: 22754189. Pubmed Central PMCID: 3162959. Epub 2012/07/04. eng. 8. Sanchez SE, Zhang C, Rene Malinow M, Ware-Jauregui S, Larrabure G, Williams MA. Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol. 2001 Mar 1;153(5):474-80. PubMed PMID: 11226979. Epub 2001/02/28. eng. 9. Ronnenberg AG, Goldman MB, Chen D, Aitken IW, Willett WC, Selhub J, et al. Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr. 2002 Dec;76(6):1385-91. PubMed PMID: 12450907. Epub 2002/11/27. eng. 10. Krishnaveni GV, Hill JC, Veena SR, Bhat DS, Wills AK, Karat CL, et al. Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes. Diabetologia. 2009 Nov;52(11):2350-8. PubMed PMID: 19707742. Pubmed Central PMCID: 3541499. Epub 2009/08/27. eng.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Çalışma
Yazarlar

Pınar Calış

Gizem Işık Bu kişi benim

Deniz Karcaaltıncaba Bu kişi benim

Yayımlanma Tarihi 28 Haziran 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 9 Sayı: 2

Kaynak Göster

APA Calış, P., Işık, G., & Karcaaltıncaba, D. (2019). Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester. Bozok Tıp Dergisi, 9(2), 42-47.
AMA Calış P, Işık G, Karcaaltıncaba D. Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester. Bozok Tıp Dergisi. Haziran 2019;9(2):42-47.
Chicago Calış, Pınar, Gizem Işık, ve Deniz Karcaaltıncaba. “Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for Each Trimester”. Bozok Tıp Dergisi 9, sy. 2 (Haziran 2019): 42-47.
EndNote Calış P, Işık G, Karcaaltıncaba D (01 Haziran 2019) Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester. Bozok Tıp Dergisi 9 2 42–47.
IEEE P. Calış, G. Işık, ve D. Karcaaltıncaba, “Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester”, Bozok Tıp Dergisi, c. 9, sy. 2, ss. 42–47, 2019.
ISNAD Calış, Pınar vd. “Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for Each Trimester”. Bozok Tıp Dergisi 9/2 (Haziran 2019), 42-47.
JAMA Calış P, Işık G, Karcaaltıncaba D. Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester. Bozok Tıp Dergisi. 2019;9:42–47.
MLA Calış, Pınar vd. “Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for Each Trimester”. Bozok Tıp Dergisi, c. 9, sy. 2, 2019, ss. 42-47.
Vancouver Calış P, Işık G, Karcaaltıncaba D. Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester. Bozok Tıp Dergisi. 2019;9(2):42-7.
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