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Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ

Yıl 2024, Cilt: 14 Sayı: 2, 85 - 91, 14.06.2024

Öz

Objective: Obesity is a condition that occurs as a result of excessive weight gain. Obesity is related with the
high risk of several diseases like cardiovascular diseases and diabetes mellitus. Elabela is a peptide that has
emerged recently and is known to affect food intake by binding to apelinergic receptors. This study aimed to
investigate the serum levels of Elabela in obese and non-obese individuals.
Material and Methods: This study involved 24 people with obesity and 25 healthy adult people as control
group. Height, weight, gender, age, waist-hip circumference, blood pressure of participants were recorded
and routine blood tests were measured. Serum concentrations of Elabela were determined using enzyme-
linked immunosorbent assay.
Results: When comparing the obese group to the controls, no statistically significant differences were observed
between the two groups in terms of diastolic blood pressure, blood urea nitrogen, creatinine, total
cholesterol, low density lipoprotein cholesterol and C-reactive protein. Similarly, both groups did not differ
statistically regarding Elabela levels. The obese group exhibited significantly elevated levels of body mass
index, waist/hip ratio, systolic blood pressure values, glucose, aspartate aminotransferase, alanine aminotransferase,
triglyceride, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) compared
to the control group. The obese group demonstrated a significantly lower level of high-density lipoprotein
cholesterol in comparison to the control group.
Conclusion: In this study, it was found that there was no relationship between Elabela levels and obesity.
However, this issue needs to be supported by further studies to clarify.

Kaynakça

  • 1. Albuquerque D, Nóbrega C, Manco L, Padez C. The contribution of genetics and environment to obesity. Br Med Bull 2017;123:159–73.
  • 2. World Obesity Day 2022 – Accelerating action to stop obesity. Available at: https://www.who.int/news/item/04-03-2022-world-obesity-day-2022-accelerating-action-to-stop-obesity. Accessed July 28, 2023.
  • 3. Chng SC, Ho L, Tian J, Reversade B. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell 2013;27:672–80.
  • 4. Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, et al. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science 2014;343:1248636.
  • 5. Xu J, Chen L, Jiang Z, Li L. Biological functions of Elabela, a novel endogenous ligand of APJ receptor. J Cell Physiol 2018;233:6472–82.
  • 6. Zhang Y, Wang Y, Lou Y, Luo M, Lu Y, Li Z, et al. Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin. Peptides (NY) 2018;109:23–32.
  • 7. Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. J Med Chem 2016;59:2962–72.
  • 8. Wang Z, Yu D, Wang M, Wang Q, Kouznetsova J, Yang R, et al. Elabela-apelin receptor signaling pathway is functional in mammalian systems. Sci Rep 2015;5:8170.
  • 9. Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation 2017;135:1160–73.
  • 10. Schreiber C, Holditch S, Generous A, Ikeda Y. Sustained ELABELA Gene Therapy in High-salt Diet-induced Hypertensive Rats. Curr Gene Ther 2017;16:349–60.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Tıbbi Biyokimya ve Metabolomik (Diğer)
Bölüm Orjinal Çalışma
Yazarlar

Neslihan Yeniel

Ayşen Caniklioğlu

Zeynep Tuğba Ozan

Müjgan Ercan

Muhammet Fevzi Polat

Yayımlanma Tarihi 14 Haziran 2024
Gönderilme Tarihi 1 Haziran 2024
Kabul Tarihi 2 Haziran 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 14 Sayı: 2

Kaynak Göster

APA Yeniel, N., Caniklioğlu, A., Ozan, Z. T., Ercan, M., vd. (2024). Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi, 14(2), 85-91.
AMA Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF. Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi. Haziran 2024;14(2):85-91.
Chicago Yeniel, Neslihan, Ayşen Caniklioğlu, Zeynep Tuğba Ozan, Müjgan Ercan, ve Muhammet Fevzi Polat. “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”. Bozok Tıp Dergisi 14, sy. 2 (Haziran 2024): 85-91.
EndNote Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF (01 Haziran 2024) Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi 14 2 85–91.
IEEE N. Yeniel, A. Caniklioğlu, Z. T. Ozan, M. Ercan, ve M. F. Polat, “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”, Bozok Tıp Dergisi, c. 14, sy. 2, ss. 85–91, 2024.
ISNAD Yeniel, Neslihan vd. “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”. Bozok Tıp Dergisi 14/2 (Haziran 2024), 85-91.
JAMA Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF. Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi. 2024;14:85–91.
MLA Yeniel, Neslihan vd. “Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ”. Bozok Tıp Dergisi, c. 14, sy. 2, 2024, ss. 85-91.
Vancouver Yeniel N, Caniklioğlu A, Ozan ZT, Ercan M, Polat MF. Evaluation of Elabela Levels in Obese Individuals OBEZ BIREYLERDE ELABELA DÜZEYLERİNİN DEĞERLENDİRİLMESİ. Bozok Tıp Dergisi. 2024;14(2):85-91.
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