MITOCHONDRIAL HAPLOGROUP DISTRIBUTION IN TURKISH ELITE ATHLETES

Öz

Bir bireyin atletik yeteneği genetik ve çevresel faktörlerin etkisindedir. Bazı mitokondriyal haplogrup ve polimorfizmlerin insan performansı ile ilişkisi gösterilmiştir. Bu çalışmanın amacı; mitokondriyal haplogrupların frekans dağılımının elit Türk güreşçiler ve sporcu olmayanlar arasında bir ilişkinin olup olmadığını değerlendirmektir. mtDNA kontrol bölgesindeki hiperdeğişken bölge I dizilemesi 52 elit Türk sporcu ve 74 sağlıklı atlet olmayan bireyden oluşan 126 kişide yapıldı. Elit Türk güreşçiler ve sporcu olmayanların dizileri revize edilmiş Cambridge Referans Dizisi ile karşılaştırıldı. Mitokondriyal haplogruplar insan mtDNA veri tabanı kullanılarak atandı ve elit Türk güreşçilerinde 15 major mitokondriyal haplogrup tespit edildi. Türk güreşçileri atlet olmayan grupla kıyaslandığında; elit Türk güreşçilerinde en yaygın haplogrupların H, U ve K haplogrupları olduğu belirlendi. Elit Türk güreşçiler ile atlet olmayanların mitokondriyal haplogrup frekansları Fisher exact testi kullanılarak karşılaştırıldı. Elit Türk güreşçiler ve sporcu olmayanlar arasında istatistiksel olarak anlamlı bir fark bulunmadı (p = 0.4186). Buna karşın, atletik olmayan gruba göre elit Türk güreşçiler arasında K ve U3 haplogruplarında önemli farklılıklar tespit edildi (p ˂ 0.05).

Anahtar Kelimeler

• Elit atlet
• mitokondriyal haplogrup
• Türk populasyonu

Mitochondrial Haplogroup Distribution in Elite Turkish Athletes

Öz

An individual’s athletic ability is influenced by genetic and environmental factors. Some mitochondrial haplogroups and polymorphisms have been shown to be associated with human performance. The aim of this study is to asses whether the frequency distribution of mitochondrial haplogroups is an association between elite Turkish wrestlers and non-athletes. Sequencing of the hypervariable region I in the mtDNA control region was performed in 126 individuals, consisting of 52 elite Turkish athletes and 74 healthy non-athletes. The sequences in the elite Turkish wrestlers and non-athletes were compared with the revised Cambridge Reference Sequence. The mitochondrial haplogroups were assigned with the human mtDNA database and 15 major mitochondrial haplogroups were identified in elite Turkish wrestlers. It was determined that the most common haplogroups in elite Turkish wrestlers compared with non-athlete group are H, U and K haplogroups. The mtDNA haplogroup frequencies of elite Turkish wrestlers and non-athletes were compared using Fisher's exact test. No statistically significant difference was found between elite Turkish wrestlers and non-athletes (p=0.4186). However, significant differences were determined in the K and U3 haplogroups among elite Turkish wrestlers compared to the non-athletic group (p ˂ 0.05).

Anahtar Kelimeler

• Elite athlete

Kaynakça

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