Hemostatik Malzemelerin Sentezi ve Karakterizasyonu

Öz

Bu çalışmada, çeşitli spor dallarındaki travmatik durumlarda, trafik kazalarında ve tıbbi müdahale olmaksızın hemen her durumda kullanılan yüksek uygulanabilirliğe sahip bir hemostatik malzeme üzerinde çalışılmıştır. Hemostatik maddenin sentezlenmesi sırasında doku rejenerasyonu ve onarımı gibi önemli özelliklere sahip olan kitin ve kitosan türevleri kullanılmıştır. Dokunmamış kitin, çeşitli şekillerde kitinin fibriller formunu üretmek için işlenmiştir. Öncelikle kitin nanofibril çözeltileri hazırlanmış ve sprey, jel ve toz numuneleri bakımından giriş malzemeleri olarak tanımlanmıştır. Böylece kitosan saflaştırma işlemlerine tabi tutulmuş ve daha sonra kitosan tuzlarını elde etmek amacıyla fizyolojik bakımından uyumlu olabilecek asitlerle çözündürülmüştür. Elde edilen çözeltilere ilave olarak kan durdurma aşamalarında mühim etkileri olabilecek koagülasyon unsurları da dâhil edilmiştir. Son olarak hemostatik malzemeler İndüktif Eşleşmiş Plazma, Diferansiyel Termal Analiz-Termal Gravimetrik Analiz, Fourier Dönüşümlü Kızılötesi Spektrometresi, X-Işını Kırınımı, X-Işını Fotoelektron Spektroskopisi ve Taramalı Elektron Mikroskopisi ile ayrıntılı olarak karakterize edilmiştir. Tüm bu parametreler tarafından üretilen hemostatik ajanın travma durumlarında yararlı bir malzeme olacağı öne sürülmüştür.

Anahtar Kelimeler

• Hemostatik
• Kitin
• Kitosan
• Kalsiyum
• Kan Durdurucu

Synthesis and Characterization of Hemostatic Materials

Öz

In this study, a very practical hemostatic material that can be used in traumatic situations in various sports, traffic accidents, and almost any situation without medical intervention was studied. Chitin and chitosan derivatives, which have important properties such as tissue regeneration and repair, were used to synthesize the hemostatic material. The nonwoven chitin was processed to produce the fibrillar form of chitin in various ways. First, chitin nanofibril solutions were prepared and defined as input materials in terms of spray, gel, and powder samples. Thus, chitosan was subjected to purification and then dissolved in physiologically compatible acids to obtain chitosan salts. In addition to the solutions obtained, elements that could have significant effects in the blood stasis phases were also included. Finally, the hemostatic materials were characterized in detail by Inductively Coupled Plasma, Differential Thermal Analysis-Thermal Gravimetric Analysis, Fourier Transform Infrared Spectrometry, X-Ray Diffraction, X-Ray Photoelectron Spectroscopy, and Scanning Electron Microscopy. It is suggested that the hemostatic agent produced by all these parameters will be a useful material in trauma situations.

Anahtar Kelimeler

• Chitin
• Chitosan
• Calcium
• Blood Stopping

Kaynakça

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