Yeni Nesil Dizileme Teknolojisine Genel Bakış

Yıl 2018, Cilt: 5 Sayı: 1, 41 - 49, 28.06.2018

Cihan Darcan , Osman Türkyılmaz

Öz

DNA, RNA ve metilasyon dizilemesi
için kullanılan yeni nesil dizileme teknolojileri bir çok bilim dalı üzerinde büyük
etkiler oluşturarak bilimsel çalışmalara yeni bakış açıları kazandırmıştır.
Yeni nesil dizileme büyük ölçekli dizileme kapasitesi ile Sanger dizilemesine
kıyasla çok daha düşük maliyetlere sahiptir. Yeni nesil dizilemenin maliyet ve
hız avantajları daha önceden neredeyse imkansız olarak düşünülen çalışmaların
yapılabilir hale gelmesine olanak sağlamıştır. Bu gelişmeler yapısal ve
işlevsel genomik anlayışımızı, temel genomikten entegre sistomiğe kadar değişen
bir çok omik kavramı ile genişletmiştir. Bu derlemede genel olarak dizileme
teknolojilerinden ve yeni nesil dizileme teknolojisinin kullanıldığı omik
alanlardan bahsedilmektedir.

Anahtar Kelimeler

Yeni Nesil Dizileme, Yüksek Çıktılı Dizileme, Omik

Kaynakça

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