Studies of Glutathione Reductase Inhibitors Activity of Copper(II) Complexes

Yıl 2019, Cilt: 6, 117 - 122, 30.09.2019

Turgay Tunç

https://doi.org/10.35193/bseufbd.577450

Öz

(S)-(+) - phenylglycinol, (1S, 2R)-2-amino-1,
2-diphenylethanol and (R)-(+)-2-amino-1, 1, 3-triphenylpropanol based chiral
copper (II) complex of Schiff bases were synthesized. The effects of these
compounds on glutathione reductase enzyme were investigated. The best
inhibitory effect was found to belong to complex 3.

Anahtar Kelimeler

Schiff bases, copper (II) complexes, Glutathione Reductase

Bakır(II) Komplekslerinin Glutatyon Redüktaz İnhibitor Çalışması

Öz

(S)-(+)-fenilglisinol, (1S, 2R)
-2-amino-1,2-difeniletanol’in ve
(R)-(+)-2-amino-1,1,3-trifenilpropanol bazlı kiral Schiff bazlarının bakır (II)
kompleksi sentezlendi. Bu bileşiklerin glutatyon redüktaz enzimi üzerindeki
etkileri incelendi. En iyi inhibitör etkisinin kompleks 3'e ait olduğu
belirlenmiştir.

Anahtar Kelimeler

Schiff baz, bakır (II) kompleksleri, Glutatyon Redüktaz

Kaynakça

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