Sentezlenen Yeni Ni (II) Komplekslerinin Spektroskopik ve antifungal özelliklerinin İncelenmesi

Tuncay KARAKURT [1] , Ayşen Alaman AĞAR [2] , Seher MERAL [3] , Abdurrahman ONARAN [4]


Bu çalışmada, 6,6'-((1E,1'E)-(propan-1,3-diilbis(azanyiliden))bis(fenilmetaniliden))bis(3 (oktiloksi)fenol) (HL1) ve 6,6’-((1E,1’E)-(etan-1,2 diilbis(azanyiliden))bis(fenilmetanyiliden))bis(3-oktiloksi)fenol) (HL2) ligandları  ile Ni metal atomunun iki farklı kompleksi hazırlanarak FT-IR ve Uv-Vis spektroskopik  yöntemleri ile karakterize edilmiştir. İki komplex yapının (HL1Ni ve HL2Ni ) deneysel olarak antifungal aktivite çalışmaları yapılmıştır. Bu çalışmada, Rhizoctonia solani ve Fusarim oxysporum f.sp radicis-lycopersici (FORL) bitki patojenlerine karşı, HL1Ni ve HL2Ni komplekslerinin in vitro koşullar altında etkinlik çalışmaları yürütülmüştür. Etkinliği belirlenen bileşiklerin doz miktarına göre test edilen patojenlere karşı orta ve yüksek düzeyde aktivite sergilediği belirlenmiştir. Ayrıca Komplex yapıların moleküller arası etkileşimlerin daha iyi anlaşılabilmesi amacıyla da bileşiklerin, HOMO-LUMO orbitalleri teoriksel olarak elde edilmiştir. Son olarak da moleküler doking çalışması ile reseptör-ligant etkileşimleri simüle edilmiştir. Bu hesaplama sonucunda bileşiklere ait affinite değerleri (Doking skoru) sırasıyla -6.9 ve -6.4 kcal/mol olarak hesaplanmıştır. Doking skoru ile kompleks yapıların HOMO orbital enerjilerinin birbirleri ile ilişkili olduğu gözlenmiştir.

DFT, HOMO-LUMO, Moleküler Doking
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Birincil Dil tr
Konular Temel Bilimler
Bölüm Makaleler
Yazarlar

Orcid: 0000-0001-6944-9883
Yazar: Tuncay KARAKURT (Sorumlu Yazar)
Ülke: Turkey


Orcid: 0000-0002-1316-4835
Yazar: Ayşen Alaman AĞAR

Orcid: 0000-0002-6309-8936
Yazar: Seher MERAL

Orcid: 0000-0003-0665-8535
Yazar: Abdurrahman ONARAN

Tarihler

Başvuru Tarihi : 8 Ağustos 2019
Kabul Tarihi : 7 Ocak 2020
Yayımlanma Tarihi : 23 Mart 2020

APA KARAKURT, T , AĞAR, A , MERAL, S , ONARAN, A . (2020). Sentezlenen Yeni Ni (II) Komplekslerinin Spektroskopik ve antifungal özelliklerinin İncelenmesi. Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi , 7 (100. Yıl Özel Sayı) , 198-216 . DOI: 10.35193/bseufbd.603561