Hepatitis B Virus: Structure and Pathogenesis

Yıl 2023, Cilt: 6 Sayı: 3, 511 - 515, 01.07.2023

Milat Araz , E. Ümit Bağrıaçık

https://doi.org/10.19127/bshealthscience.1283758

Öz

The hepatitis B virus is a member of the hepadnaviridae family. This virus causes chronic and acute hepatitis diseases. More than 17% of hepatitis B carriers are chronic patients at high risk for liver cancer and cirrhosis. Although various vaccines are available, HBV is still a major health problem worldwide. It points out that abnormal host immune responses are a contributing factor to HBV persistence and that differences in persistent viral populations in the host may be associated with susceptibility or resistance to antiviral immune responses as well as various therapeutics, complicating HBV treatment. Since it is practically not possible to produce the whole hepatitis B virus, antigenic structures are obtained by recombinant DNA technology. When it comes to vaccine development, it would be wise to focus research on efforts to develop vaccines that target local traits attributed to various viral subtypes unique to various populations. The main classification of the HBV subtype is divided into 4 serotypes (adr, adw, Ayr, and ayw). The ayw serotype is the most common in Türkiye, with an estimated 3.3 million cases of hepatitis B. We will discuss the hepatitis B virus and the immune system's part in the pathogenesis of viruse, to illustrate targets that could be beneficial for vaccine development.

Anahtar Kelimeler

Hepatitis B, Vaccines, infection

Hepatit B Virüsü: Yapı ve Patogenez

Öz

Hepatit B virüsü, hepadnaviridae ailesinin bir üyesidir. Bu virüs kronik ve akut hepatit hastalıklarına neden olmaktadır. Hepatit B taşıyıcılarının %17 den fazlası karaciğer kanseri ve siroz açısından yüksek risk taşıyan kronik hastalardır. Çeşitli aşıların mevcut olmasına rağmen, HBV hala dünya genelinde önemli bir sağlık problemidir. Anormal konakçı immün yanıtlarının HBV kalıcılığına katkıda bulunan bir faktör olduğuna ve konakçıdaki persistan viral popülasyonlardaki farklılıkların, çeşitli terapötiklerin yanı sıra antiviral immün yanıtlara karşı duyarlılıkla veya dirençle bağlantılı olabileceğine işaret etmektedir ve bu da HBV tedavisini zorlaştırmaktadır. Hepatit B virüsünün tamamının üretilmesi pratik olarak mümkün olmadığından antijenik yapılar, rekombinant DNA teknolojisi ile elde edilmektedir. Aşı geliştirme söz konusu olduğunda, çeşitli popülasyonlara özgü çeşitli viral alt tiplere atfedilen yerel özellikleri hedefleyen aşılar geliştirme çabalarına yönelik araştırmalara yönlenmek akıllıca olacaktır. HBV alt tipinin ana sınıflandırması 4 serotipe (adr, adw, ayr, and ayw) ayrılır. Türkiye'de en yaygın ve tahminen 3,3 milyon Hepatit B vakası bulunan, ayw serotipidir. Aşı geliştirmeye faydalı olabilecek hedefleri göstermek amacıyla, hepatit B virüsünü ve virüsün patojenitezinde bağışıklık sisteminin rolünü tartışacağız.

Anahtar Kelimeler

Hepatit B, Aşılar, Enfeksiyon

Kaynakça

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