The relationship of laboratory parameters and rates with prognosis and mortality in COVID-19 infection

Öz

Objective:In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluate the hematological and biochemical parameters at the time of admission to the hospital. Methods:This retrospective study was performed in a multicenter study in April and October 2020. Demographic characteristics, clinical features, age, gender and length of stay of patients who exitus (EX) and were discharged due to COVID-19 were examined. Results:Of the patients (n:180) included in the study, 89 were female and 91 were male. There was a significant difference between the patients who were discharged from the hospital and died gender and complaints at the time of admission (p<0.05). There was no significant difference between age distribution and comorbid factors (p>0.05). While the length of stay, platelet (PLT), mean corpuscular volume (MCV), serum C-reactive protein (CRP), albumin, lymphocyte, monocyte, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH), ferritin, international normalized ratio, procalcitonin (PCT), troponin, and white blood cell counts are all increased in EX. There is a statistically significant difference in red blood cell distribution width (RDW) between EX and discharge patients (p<0.05), as well as in monocyte/albumin ratios, procalcitonin/albumin ratios, CRP/albumin ratios, LDH/albumin ratios, and ürea/albumin ratios. There is not significant for lymphocyte/monocyte ratio (p>0.05). While the RDW, monocyte/albumin, procalcitonin/albumin, CRP/albumin, LDH/albumin, and ürea/albumin ratios are increased in EX patients, the PCT/PLT and MPV/PLT ratios are increased in discharged patients. Conclusion: In this study, we demonstrated that hematological and biochemical markers may be utilized as an early prognostic indicator for patients identified with COVID-19.

Anahtar Kelimeler

• COVID-19
• Plateletcrit/Platelet
• Platelet/Mean Platelet Volum
• Lymphocyte/Monocyte monocytes
• C-Reactive Protein/Albumin
• Mortality.

Laboratuvar parametreleri ve oranlarının COVID-19 enfeksiyonunda prognoz ve mortalite ile ilşkisi

Öz

Amaç: Bu çalışma amaç, COVID-19 hastalarında hastaneye başvuru anındaki hematolojik ve biyokimyasal parametreleri ile klinik seyir ve prognozu değerlendirmektir. Yöntem: Bu retrospektif çalışma, Nisan ve Ekim 2020'de çok merkezli çalışma olarak yapıldı. COVID-19 nedeniyle taburcu olan ve ölen (EX) hastaların demografik özellikleri, klinik özellikleri, yaşı, cinsiyeti ve kalış süreleri incelendi. Bulgular: Çalışmaya alınan hastaların (n:180) 89'u kadın, 91'i erkekti. Hastaneden taburcu olan ve ex olan hastalar arasında cinsiyet ve başvuru anındaki şikayetleri arasında anlamlı fark vardı (p<0.05). Yaş dağılımı ile komorbid faktörler arasında ise anlamlı fark yoktu (p>0.05). Kalış süresi, trombosit (PLT), ortalama korpüsküler hacim (MCV), serum C-reaktif protein (CRP), albümin, lenfosit, monosit, alanin aminotransferaz, aspartat aminotransferaz, laktat dehidrojenaz (LDH), ferritin, prokalsitonin (PCT), troponin ve beyaz kan hücresi sayılarının tümünün ex olan hastalarda arttığı gözlendi. EX ve taburcu olan hastalar arasında kırmızı kan hücresi dağılım genişliği (RDW), monosit/albümin oranları, prokalsitonin/albümin oranları, CRP/albümin oranları, LDH/albümin oranları, ve üre/albümin oranları arasında anlamlı fark vardı (p<0.05). Lenfosit/monosit oranı açısından anlamlı fark yoktu (p>0.05). EX olan hastalarında RDW, monosit/albümin, prokalsitonin/albümin, CRP/albümin, LDH/albümin ve üre/albümin oranları artarken, taburcu olan hastalarda PCT/PLT ve MPV/PLT oranları artmaktaydı. Sonuç: Çalışmada, COVID-19 ile hastaları için hematolojik ve biyokimyasal belirteçlerin erken prognostik gösterge olarak kullanılabileceğini gösterilmiştir.

Anahtar Kelimeler

• COVID-19
• Plateletkrit/Platelet
• Platelet/Ortalama Trombosit Hacmi
• Lenfosit/Monosit monositleri
• C-Reaktif Protein/Albümin
• Mortalite.

Kaynakça

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