Endometrioid Over Kanseri ile Berrak Hücreli Over Kanseri Olan Olguların Prognozlarının Karşılaştırılması

Öz

Amaç: Endometriozis ilişkili kanserler olarak adlandırılan endometrioid over kanseri (EnOK) ve berrak hücreli over kanseri (BHOK) olgularının özellikleri, klinik yaklaşımları ve sağ kalımlarının incelenmesi amaçlanmıştır. Materyal ve Metod: Ankara Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim Araştırma Hastanesi Jinekolojik Onkoloji Kliniği’nde opere edilmiş endometrioid over kanseri (n=46) ve berrak hücreli over kanseri tanısı alan (n=32) olguların verileri retrospektif olarak hasta dosyalarından tarandı. Demografik, klinikopatolojik ve sağ kalım verileri toplanarak iki grup arasında prognoz karşılaştırıldı. Bulgular: BHOK grubunda 5 yıllık hastalıksız sağ kalımın EnOK grubuna göre istatistiksel olarak anlamlı düzeyde azaldığı bulundu (p=0.027). Erken evrede (evre 1-2) tanı alan olgularda 5 yıllık hastalıksız sağ kalım ve genel sağ kalımın benzer olduğu görüldü. İleri evrede (evre 3-4) tanı alan BHOK olgularında ise 5 yıllık genel sağ kalımın istatistiksel olarak anlamlı düzeyde azaldığı bulundu (p=0.043). EnOK ve BHOK olgularında benzer oranda endometriozis olduğu görüldü. Endometriozis olan EnOK olgularında 5 yıllık genel sağ kalım ve hastalıksız sağ kalımın daha iyi olduğu, endometriozis olan ve olmayan BHOK olgularında ise 5 yıllık genel sağ kalım ve hastalıksız sağ kalımın farklı olmadığı bulundu. Sonuç: Endometriozis ilişkili endometrioid over kanserinin prognozu daha iyidir. Erken evrede berrak hücreli over kanseri ve endometrioid over kanserinin prognozlarının benzer olduğu, ileri evrede berrak hücreli over kanserinin prognozunun endometrioid over kanserine göre daha kötü olduğu ve evreden bağımsız berrak hücreli over kanserinin 5 yıllık hastalıksız sağ kalımın endometrioid over kanserinden daha kötü olduğu gözükmektedir.

Anahtar Kelimeler

• Endometrioid over kanseri
• berrak hücreli over kanseri
• endometriozis
• prognoz

Proje Numarası

30.12.2015/13

Etik Beyan

Ankara Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi Eğitim Planlama ve Koordinasyon Kurulu’ndan (EPK) çalışma için onay alındı. (EPK numarası: 30.12.2015/13)

Comparison Of Prognosis İn Cases With Endometrioid Ovarian Cancer And Clear Cell Ovarian Cancer

Öz

Objective: This study aims to compare the characteristics, clinical approaches, and survival outcomes between cases of endometrioid ovarian cancer (EnOC) and clear cell ovarian cancer (CCOC), referred to as endometriosis-related cancers. Material And Method: This retrospective analysis involved the medical records of 46 patients with EnOC and 32 patients with CCOC. All patients underwent surgical treatment at the Gynecology Oncology Clinic of Ankara Dr. Zekai Tahir Burak Women's Health Training and Research Hospital. This study involved collecting and comparing demographic, clinicopathological, and survival data between the two groups. Results: The analysis revealed a significantly lower 5-year disease-free survival rate in the CCOC group compared to the EnOC group (p = 0.027). In early-stage diagnoses (stage I-II), the 5-year disease-free and overall survival rates were comparable between the two groups. However, for patients diagnosed with CCOC at an advanced stage (stage III-IV), there was a significant decrease in the 5-year overall survival rate (p = 0.043). The incidence of endometriosis was similar in both cancer types. Patients with EnOC accompanied by endometriosis showed better 5-year overall and disease-free survival rates. Conversely, these survival rates in CCOC patients, whether with or without endometriosis, showed no significant difference. Conclusion: EnOC, when associated with endometriosis, generally has a better prognosis. In early stages, CCOC and EnOC present similar prognoses. However, in advanced stages, the prognosis for CCOC is poorer prognosis compared to EnOC. Irrespective of the stage, the 5-year disease-free survival rate for CCOC is consistently lower than that for EnOC.

Anahtar Kelimeler

• Endometrioid ovarian cancer
• clear cell ovarian cancer
• endometriosis
• prognosis

Proje Numarası

30.12.2015/13

Kaynakça

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