BİR İLAÇ MONOGRAFI : MEROPENEM-VABORBAKTAM

Öz

Meropenem Vaborbaktam yakın zamanda Amerika’da kullanıma sunulmuş, iki faz III çalışmasını başarıyla tamamlamış yeni bir β-laktamaz inhibitörlü karbapenem kombinasyonudur. Kimyasal yapısı, etki mekanizması ve yan etki profili bakımından diğer β-laktam antibiyotiklerle benzerlik taşımakla birlikte antibakteriyel etkinliği açısından birçok üstünlüğe sahip olduğu belirtilmektedir. Başta Klebsiella pneumoniae carbapenemase (KPC) olmak üzere belirli bazı karbapenemaz türleri üzerinde etkili bulunması bu üstünlüğün en önemli sebebidir. Karbapenem dirençli bakterilerle gerçekleştirilen TANGO II’de mümkün olan en iyi tedavi ile meropenem-vaborbaktam alan hasta grupları kıyaslanmış, meropenem-vaborbaktamın beklenenin üzerinde üstünlük sağlamasıyla çalışma planlanandan önce sonlandırılmıştır. Günümüzde Meropenem – vaborbaktam kombinasyonu dirençli Gram negatif bakterilerle meydana gelen komplike idrar yolları enfeksiyonu / pyelonefrit için ruhsatlandırılmış; ventilatör ilişkili pnömoni için Faz III çalışmaları devam etmektedir.

Anahtar Kelimeler

• Meropenem-vaborbaktam,Karpabepenem dirençli Enterobacteriaceae,KPC bakteriler,Metallo-beta-laktamazlar,Karbapenemazlar

Kaynakça

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