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Fekal Mikrobiyota Transplantasyonu (FMT)

Yıl 2017, - Mikrobiyota, 132 - 140, 15.11.2017

Ahmet Uygun

Öz

Gaita nakli, Clostridium difficile infeksiyonu için önemli bir tedavi seçeneğidir. Gaita naklinin, bağırsak mikroflorasındaki değişiklikler ile ilgili diğer hastalıkların tedavisinde, rol oynayabileceği konusunda ümit verici bulgular tespit edilmiştir. Gaita nakli, bağırsak mikroflorasındaki değişiklikler ile ilgili spesifik hastalıkları tedavi etmek için, sağlıklı bir donörden alınan gaitanın, alıcı hastanın bağırsağına yerleştirilmesidir. Gaita nakli ile ilgili olarak, donör seçimi, donör taraması, yapılması gereken standart protokoller, metodlar ve uzun dönem güvenlik sonuçları dahil, cevaplanmamış bir çok soru hala vardır.

Anahtar Kelimeler

Fekal mikrobiyota transplantasyonu Ülseratif kolitis Crohn Hastalığı İrritabl bağırsak sendromu

Kaynakça

  • 1. Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6578-83. Review.
  • 2. Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, Louis P, Flint HJ. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond). 2008 Nov;32(11):1720-4. doi: 10.1038/ijo.2008.155.
  • 3. Koren O, Spor A, Felin J, Fåk F, Stombaugh J, Tremaroli V, Behre CJ, Knight R, Fagerberg B, Ley RE, Bäckhed F. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4592-8. doi: 10.1073/ pnas.1011383107.
  • 4. Choi HH, Cho Y-S. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clinical Endoscopy. 2016;49(3):257-265. doi:10.5946/ce.2015.117.
  • 5. Lee HJ, Choi JK, Ryu HS, et al. Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders. Journal of Neurogastroenterology and Motility. 2017;23(1):9-19. doi:10.5056/jnm16124.
  • 6. Borody TJ, Warren EF, Leis S, Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003 Jul;37(1):42-7.
  • 7. Zhang F, Luo W, Shi Y, Fan Z, Ji G. Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol. 2012 Nov;107(11):1755; author reply p.1755-6. doi: 10.1038/ ajg.2012.251.
  • 8. EISEMAN B, SILEN W, BASCOM GS, KAUVAR AJ. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery. 1958 Nov;44(5):854-9.
  • 9. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human infl ammatory bowel diseases. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5.
  • 10. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial fl ora. Science. 2005 Jun 10;308(5728):1635-8.
  • 11. Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P. Effect of inulin on the human gut microbiota: stimulation of Bifi dobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr. 2009 Feb;101(4):541-50. doi: 10.1017/ S0007114508019880.
  • 12. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971- 5. doi: 10.1073/pnas.1002601107.
  • 13. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, van den Brandt PA, Stobberingh EE. Factors infl uencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006 Aug;118(2):511-21.
  • 14. Sjögren YM, Jenmalm MC, Böttcher MF, Björkstén B, Sverremark- Ekström E. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy. 2009 Apr;39(4):518- 26. doi: 10.1111/j.1365-2222.2008.03156.x.
  • 15. Mariat D, Firmesse O, Levenez F, Guimarβes V, Sokol H, Doré J, Corthier G, Furet JP. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 2009 Jun 9;9:123. doi: 10.1186/1471-2180-9-123.
  • 16. Claesson MJ, Cusack S, O'Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, van Sinderen D, O'Connor M, Harnedy N, O'Connor K, Henry C, O'Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O'Toole PW. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4586-91. doi: 10.1073/pnas.1000097107.
  • 17. Kau AL, Ahern PP, Griffi n NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011 Jun 15;474(7351):327-36. doi: 10.1038/nature10213. Review.
  • 18. Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010 Jan;26(1):5-11. doi: 10.1097/MOG.0b013e328333d751. Review.
  • 19. Wu X, Ma C, Han L, Nawaz M, Gao F, Zhang X, Yu P, Zhao C, Li L, Zhou A, Wang J, Moore JE, Millar BC, Xu J. Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol. 2010 Jul;61(1):69-78. doi: 10.1007/s00284-010- 9582-9.
  • 20. Choi HH, Cho Y-S. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clinical Endoscopy. 2016;49(3):257-265. doi:10.5946/ce.2015.117.
  • 21. Evrensel A, Ceylan ME. Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders. Clinical Psychopharmacology and Neuroscience. 2016;14(3):231-237. doi:10.9758/ cpn.2016.14.3.231.
  • 22. Drekonja D, Reich J, Gezahegn S, Greer N, Shaukat A, MacDonald R, Rutks I, Wilt TJ. Fecal Microbiota Transplantation for Clostridium diffi cile Infection: A Systematic Review. Ann Intern Med. 2015 May 5;162(9):630-8. doi: 10.7326/M14-2693. Review.
  • 23. Youngster I, Sauk J, Pindar C, et al. Fecal Microbiota Transplant for Relapsing Clostridium diffi cile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study. Clinical Infectious Diseases: An Offi cial Publication of the Infectious Diseases Society of America. 2014;58(11):1515- 1522. doi:10.1093/cid/ciu135.
  • 24. Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium diffi cile infection. Clin Infect Dis. 2011 Nov;53(10):994- 1002. doi: 10.1093/cid/cir632. Review.
  • 25. Cammarota G, Ianiro G, Tilg H, Rajiliβ-Stojanoviβ M, Kump P, Satokari R, Sokol H, Arkkila P, Pintus C, Hart A, Segal J, Aloi M, Masucci L, Molinaro A, Scaldaferri F, Gasbarrini G, Lopez-Sanroman A, Link A, de Groot P, de Vos WM, Högenauer C, Malfertheiner P, Mattila E, Milosavljeviβ T, Nieuwdorp M, Sanguinetti M, Simren M, Gasbarrini A; European FMT Working Group. European consensus conference on faecal microbiota transplantation in clinical practice. Gut. 2017 Apr;66(4):569-580. doi: 10.1136/gutjnl-2016-313017.
  • 26. Bennet JD, Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic fl ora. Lancet. 1989 Jan 21;1(8630):164.
  • 27. Borody TJ, Warren EF, Leis S, Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003 Jul;37(1):42-7.
  • 28. Borody T, Wettstein A, Campbell J, Leis S, Torres T, Finlayson S, Nowak A. Fecal microbiota transplantation in ulcerative colitis: review of 24 years experience. Am J Gastroenterol 2012. Abstract 1644.
  • 29. Vermeire S, Joossens M, Verbeke K, et al. Pilot study on the safety and effi cacy of faecal microbiota transplantation in refractory Crohn’s disease. Gastroenterology. 2012;142(5 suppl 1):S360.
  • 30. Anderson JL, Edney RJ, Whelan K. Systematic review: faecal microbiota transplantation in the management of infl ammatory bowel disease. Aliment Pharmacol Ther. 2012 Sep;36(6):503-16. doi: 10.1111/j.1365-2036.2012.05220.x.
  • 31. Sha S, Liang J, Chen M, Xu B, Liang C, Wei N, Wu K. Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children. Aliment Pharmacol Ther. 2014 May;39(10):1003-32. doi: 10.1111/apt.12699.
  • 32. Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for infl ammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis. 2014 Dec;8(12):1569-81. doi: 10.1016/j. crohns.2014.08.006.
  • 33. Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, Lee CH. Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial. Gastroenterology. 2015 Jul;149(1):102-109.e6. doi: 10.1053/j. gastro.2015.04.001.
  • 34. Rossen NG, Fuentes S, van der Spek MJ, Tijssen JG, Hartman JH, Dufl ou A, Löwenberg M, van den Brink GR, Mathus-Vliegen EM, de Vos WM, Zoetendal EG, D'Haens GR, Ponsioen CY. Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis. Gastroenterology. 2015 Jul;149(1):110-118. e4. doi: 10.1053/j.gastro.2015.03.045.
  • 35. Cui B, Feng Q, Wang H, Wang M, Peng Z, Li P, Huang G, Liu Z, Wu P, Fan Z, Ji G, Wang X, Wu K, Fan D, Zhang F. Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and effi cacy trial results. J Gastroenterol Hepatol. 2015 Jan;30(1):51-8. doi: 10.1111/jgh.12727.
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  • 41. Borody TJ, Campbell J. Fecal microbiota transplantation: techniques, applications, and issues. Gastroenterol Clin North Am. 2012 Dec;41(4):781-803. doi: 10.1016/j.gtc.2012.08.008. Review.
  • 42. roniadis OC, Brandt LJ. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol. 2013 Jan;29(1):79- 84. doi: 10.1097/MOG.0b013e32835a4b3e. Review.
  • 43. Youngster I, Sauk J, Pindar C, et al. Fecal Microbiota Transplant for Relapsing Clostridium diffi cile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study. Clinical Infectious Diseases: An Offi cial Publication of the Infectious Diseases Society of America. 2014;58(11):1515- 1522. doi:10.1093/cid/ciu135.
  • 44. Satokari R, Mattila E, Kainulainen V, Arkkila PE. Simple faecal preparation and effi cacy of frozen inoculum in faecal microbiota transplantation for recurrent Clostridium diffi cile infection-- an observational cohort study. Aliment Pharmacol Ther. 2015 Jan;41(1):46-53. doi: 10.1111/apt.13009.
  • 45. Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc. 2013 Aug;78(2):240-9. doi: 10.1016/j. gie.2013.03.1329.
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  • 56. Satokari R, Fuentes S, Mattila E, Jalanka J, de Vos WM, Arkkila P. Fecal transplantation treatment of antibiotic-induced, noninfectious colitis and long-term microbiota follow-up. Case Rep Med 2014. Article ID 913867. http://dx.doi.org/10.1155/2014/913867

Fecal Microbiota Transplantation (FMT)

Yıl 2017, - Mikrobiyota, 132 - 140, 15.11.2017

Ahmet Uygun

Öz

Fecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium diffi cile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Fecal microbiota transplantation (FMT) consists of the infusion of feces from a healthy donor to the GI tract of a recipient patient, in order to treat a specifi c disease associated with alteration of gut microbiota. There are still many unanswered questions regarding FMT, including donor selection and screening, standardized protocols, methodology, long-term safety, and regulatory issues.

Anahtar Kelimeler

Fecal microbiota transplantation Ülcerative colitis; Crohn disease Irritable bowel syndrome

Kaynakça

  • 1. Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6578-83. Review.
  • 2. Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, Louis P, Flint HJ. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond). 2008 Nov;32(11):1720-4. doi: 10.1038/ijo.2008.155.
  • 3. Koren O, Spor A, Felin J, Fåk F, Stombaugh J, Tremaroli V, Behre CJ, Knight R, Fagerberg B, Ley RE, Bäckhed F. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4592-8. doi: 10.1073/ pnas.1011383107.
  • 4. Choi HH, Cho Y-S. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clinical Endoscopy. 2016;49(3):257-265. doi:10.5946/ce.2015.117.
  • 5. Lee HJ, Choi JK, Ryu HS, et al. Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders. Journal of Neurogastroenterology and Motility. 2017;23(1):9-19. doi:10.5056/jnm16124.
  • 6. Borody TJ, Warren EF, Leis S, Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003 Jul;37(1):42-7.
  • 7. Zhang F, Luo W, Shi Y, Fan Z, Ji G. Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol. 2012 Nov;107(11):1755; author reply p.1755-6. doi: 10.1038/ ajg.2012.251.
  • 8. EISEMAN B, SILEN W, BASCOM GS, KAUVAR AJ. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery. 1958 Nov;44(5):854-9.
  • 9. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human infl ammatory bowel diseases. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5.
  • 10. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial fl ora. Science. 2005 Jun 10;308(5728):1635-8.
  • 11. Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P. Effect of inulin on the human gut microbiota: stimulation of Bifi dobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr. 2009 Feb;101(4):541-50. doi: 10.1017/ S0007114508019880.
  • 12. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971- 5. doi: 10.1073/pnas.1002601107.
  • 13. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, van den Brandt PA, Stobberingh EE. Factors infl uencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006 Aug;118(2):511-21.
  • 14. Sjögren YM, Jenmalm MC, Böttcher MF, Björkstén B, Sverremark- Ekström E. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy. 2009 Apr;39(4):518- 26. doi: 10.1111/j.1365-2222.2008.03156.x.
  • 15. Mariat D, Firmesse O, Levenez F, Guimarβes V, Sokol H, Doré J, Corthier G, Furet JP. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 2009 Jun 9;9:123. doi: 10.1186/1471-2180-9-123.
  • 16. Claesson MJ, Cusack S, O'Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, van Sinderen D, O'Connor M, Harnedy N, O'Connor K, Henry C, O'Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O'Toole PW. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4586-91. doi: 10.1073/pnas.1000097107.
  • 17. Kau AL, Ahern PP, Griffi n NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011 Jun 15;474(7351):327-36. doi: 10.1038/nature10213. Review.
  • 18. Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010 Jan;26(1):5-11. doi: 10.1097/MOG.0b013e328333d751. Review.
  • 19. Wu X, Ma C, Han L, Nawaz M, Gao F, Zhang X, Yu P, Zhao C, Li L, Zhou A, Wang J, Moore JE, Millar BC, Xu J. Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol. 2010 Jul;61(1):69-78. doi: 10.1007/s00284-010- 9582-9.
  • 20. Choi HH, Cho Y-S. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clinical Endoscopy. 2016;49(3):257-265. doi:10.5946/ce.2015.117.
  • 21. Evrensel A, Ceylan ME. Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders. Clinical Psychopharmacology and Neuroscience. 2016;14(3):231-237. doi:10.9758/ cpn.2016.14.3.231.
  • 22. Drekonja D, Reich J, Gezahegn S, Greer N, Shaukat A, MacDonald R, Rutks I, Wilt TJ. Fecal Microbiota Transplantation for Clostridium diffi cile Infection: A Systematic Review. Ann Intern Med. 2015 May 5;162(9):630-8. doi: 10.7326/M14-2693. Review.
  • 23. Youngster I, Sauk J, Pindar C, et al. Fecal Microbiota Transplant for Relapsing Clostridium diffi cile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study. Clinical Infectious Diseases: An Offi cial Publication of the Infectious Diseases Society of America. 2014;58(11):1515- 1522. doi:10.1093/cid/ciu135.
  • 24. Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium diffi cile infection. Clin Infect Dis. 2011 Nov;53(10):994- 1002. doi: 10.1093/cid/cir632. Review.
  • 25. Cammarota G, Ianiro G, Tilg H, Rajiliβ-Stojanoviβ M, Kump P, Satokari R, Sokol H, Arkkila P, Pintus C, Hart A, Segal J, Aloi M, Masucci L, Molinaro A, Scaldaferri F, Gasbarrini G, Lopez-Sanroman A, Link A, de Groot P, de Vos WM, Högenauer C, Malfertheiner P, Mattila E, Milosavljeviβ T, Nieuwdorp M, Sanguinetti M, Simren M, Gasbarrini A; European FMT Working Group. European consensus conference on faecal microbiota transplantation in clinical practice. Gut. 2017 Apr;66(4):569-580. doi: 10.1136/gutjnl-2016-313017.
  • 26. Bennet JD, Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic fl ora. Lancet. 1989 Jan 21;1(8630):164.
  • 27. Borody TJ, Warren EF, Leis S, Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003 Jul;37(1):42-7.
  • 28. Borody T, Wettstein A, Campbell J, Leis S, Torres T, Finlayson S, Nowak A. Fecal microbiota transplantation in ulcerative colitis: review of 24 years experience. Am J Gastroenterol 2012. Abstract 1644.
  • 29. Vermeire S, Joossens M, Verbeke K, et al. Pilot study on the safety and effi cacy of faecal microbiota transplantation in refractory Crohn’s disease. Gastroenterology. 2012;142(5 suppl 1):S360.
  • 30. Anderson JL, Edney RJ, Whelan K. Systematic review: faecal microbiota transplantation in the management of infl ammatory bowel disease. Aliment Pharmacol Ther. 2012 Sep;36(6):503-16. doi: 10.1111/j.1365-2036.2012.05220.x.
  • 31. Sha S, Liang J, Chen M, Xu B, Liang C, Wei N, Wu K. Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children. Aliment Pharmacol Ther. 2014 May;39(10):1003-32. doi: 10.1111/apt.12699.
  • 32. Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for infl ammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis. 2014 Dec;8(12):1569-81. doi: 10.1016/j. crohns.2014.08.006.
  • 33. Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, Lee CH. Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial. Gastroenterology. 2015 Jul;149(1):102-109.e6. doi: 10.1053/j. gastro.2015.04.001.
  • 34. Rossen NG, Fuentes S, van der Spek MJ, Tijssen JG, Hartman JH, Dufl ou A, Löwenberg M, van den Brink GR, Mathus-Vliegen EM, de Vos WM, Zoetendal EG, D'Haens GR, Ponsioen CY. Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis. Gastroenterology. 2015 Jul;149(1):110-118. e4. doi: 10.1053/j.gastro.2015.03.045.
  • 35. Cui B, Feng Q, Wang H, Wang M, Peng Z, Li P, Huang G, Liu Z, Wu P, Fan Z, Ji G, Wang X, Wu K, Fan D, Zhang F. Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and effi cacy trial results. J Gastroenterol Hepatol. 2015 Jan;30(1):51-8. doi: 10.1111/jgh.12727.
  • 36. Uygun A, Ozturk K, Demirci H, et al. Fecal microbiota transplantation is a rescue treatment modality for refractory ulcerative colitis. Scalisi. G, ed. Medicine. 2017;96(16):e6479. doi:10.1097/ MD.0000000000006479.
  • 37. Li N, Tian H, Ma C, Ding C, Ge X, Gu L, Zhang X, Yang B, Hua Y, Zhu Y, Zhou Y. Effi cacy analysis of fecal microbiota transplantation in the treatment of 406 cases with gastrointestinal disorders. Zhonghua Wei Chang Wai Ke Za Zhi; 2017 Jan 25;20(1):40-46
  • 38. Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R, Xuan W, Lin E, Mitchell HM, Borody TJ. Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet. 2017 Mar 25;389(10075):1218- 1228. doi: 10.1016/S0140-6736(17)30182-4.
  • 39. Pinn DM, Aroniadis OC, Brandt LJ. Is fecal microbiota transplantation (FMT) an effective treatment for patients with functional gastrointestinal disorders (FGID)? Neurogastroenterol Motil. 2015 Jan;27(1):19-29. doi: 10.1111/nmo.12479. Epub 2014 Nov 25. Review.
  • 40. Rajiliβ-Stojanoviβ M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S, de Vos WM. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology. 2011 Nov;141(5):1792-801. doi: 10.1053/j.gastro.2011.07.043.
  • 41. Borody TJ, Campbell J. Fecal microbiota transplantation: techniques, applications, and issues. Gastroenterol Clin North Am. 2012 Dec;41(4):781-803. doi: 10.1016/j.gtc.2012.08.008. Review.
  • 42. roniadis OC, Brandt LJ. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol. 2013 Jan;29(1):79- 84. doi: 10.1097/MOG.0b013e32835a4b3e. Review.
  • 43. Youngster I, Sauk J, Pindar C, et al. Fecal Microbiota Transplant for Relapsing Clostridium diffi cile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study. Clinical Infectious Diseases: An Offi cial Publication of the Infectious Diseases Society of America. 2014;58(11):1515- 1522. doi:10.1093/cid/ciu135.
  • 44. Satokari R, Mattila E, Kainulainen V, Arkkila PE. Simple faecal preparation and effi cacy of frozen inoculum in faecal microbiota transplantation for recurrent Clostridium diffi cile infection-- an observational cohort study. Aliment Pharmacol Ther. 2015 Jan;41(1):46-53. doi: 10.1111/apt.13009.
  • 45. Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc. 2013 Aug;78(2):240-9. doi: 10.1016/j. gie.2013.03.1329.
  • 46. Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology. 2015 Jul;149(1):223-37. doi: 10.1053/j.gastro.2015.05.008.
  • 47. Liao CH, Shollenberger LM. Survivability and long-term preservation of bacteria in water and in phosphate-buffered saline. Lett Appl Microbiol. 2003;37(1):45-50.
  • 48. Costello SP, Tucker EC, La Brooy J, Schoeman MN, Andrews JM. Establishing a Fecal Microbiota Transplant Service for the Treatment of Clostridium diffi cile Infection. Clin Infect Dis. 2016 Apr 1;62(7):908-14. doi: 10.1093/cid/civ994.
  • 49. Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A, Weese JS, Collins S, Moayyedi P, Crowther M, Ropeleski MJ, Jayaratne P, Higgins D, Li Y, Rau NV, Kim PT. Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium diffi cile Infection: A Randomized Clinical Trial. JAMA. 2016 Jan 12;315(2):142-9. doi: 10.1001/jama.2015.18098.
  • 50. Frank, J; Hogenauer, C; Grochenig, HP; Hoffmann, KM; Reicht, G; Wenzl, HH; Petritsch, W; Kump, PK. Safety of fecal microbiota transplantation in patients with chronic colitis and immunosuppressive treatement. J CROHNS COLITIS. 2015; 9: S245-S246.
  • 51. Baxter M, Ahmad T, Colville A, Sheridan R. Fatal Aspiration Pneumonia as a Complication of Fecal Microbiota Transplant. Clin Infect Dis. 2015 Jul 1;61(1):136-7. doi: 10.1093/cid/civ247.
  • 52. Link A, Lachmund T, Schulz C, Weigt J, Malfertheiner P, Endoscopic peroral jejunal fecal microbiota transplantation., Digestive and Liver Disease (2016), http://dx.doi.org/10.1016/j.dld.2016.08.110
  • 53. Agrawal M, Aroniadis OC, Brandt LJ, Kelly C, Freeman S, Surawicz C, Broussard E, Stollman N, Giovanelli A, Smith B, Yen E, Trivedi A, Hubble L, Kao D, Borody T, Finlayson S, Ray A, Smith R. The Long-term Effi cacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium diffi cile Infection in 146 Elderly Individuals. J Clin Gastroenterol. 2016 May- Jun;50(5):403-7. doi: 10.1097/MCG.0000000000000410.
  • 54. Alang N, Kelly CR. Weight Gain After Fecal Microbiota Transplantation. Open Forum Infectious Diseases. 2015;2(1):ofv004. doi:10.1093/ ofi d/ofv004.
  • 55. Baxter M, Colville A. Adverse events in faecal microbiota transplant: a review of the literature. J Hosp Infect. 2016 Feb;92(2):117-27. doi: 10.1016/j.jhin.2015.10.024.
  • 56. Satokari R, Fuentes S, Mattila E, Jalanka J, de Vos WM, Arkkila P. Fecal transplantation treatment of antibiotic-induced, noninfectious colitis and long-term microbiota follow-up. Case Rep Med 2014. Article ID 913867. http://dx.doi.org/10.1155/2014/913867
Toplam 56 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Ahmet Uygun Bu kişi benim

Yayımlanma Tarihi 15 Kasım 2017
Kabul Tarihi 10 Ekim 2017
Yayımlandığı Sayı Yıl 2017 - Mikrobiyota

Kaynak Göster

AMA Uygun A. Fecal Microbiota Transplantation (FMT). J Biotechnol and Strategic Health Res. Kasım 2017;1:132-140.

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