Cardiovasculer Diseases and Microbiota

Yıl 2017, - Mikrobiyota, 141 - 147, 15.11.2017

Perihan Varım Mehmet Bülent Vatan Ceyhun Varım

Öz

Cardiovascular Diseases (CVD) are the most common cause of death in worldwide It accounts for 31% of all deaths in the world. Risk factors for CVD are smoking, unhealthy diet, obesity, physical inactivity, high blood pressure (hypertension), high blood fat and diabetes Bacteria that have been settled in various parts of the body such as skin, mouth, vagina, intestines are called “floras”, new name is called “microbiota”. The genome of microorganisms is called “ microbiome “ The human body is composed of 10% of its own cells and 90% of the existing microbial cells.Intestinal microbiota; carries out very important tasks on the physiological, metabolic and immunological systems in our body.Intestinal bacteria that control the necessary metabolic processes by assuming the role of energy carrier or releasing immunomodulating substances because of this it is now defi ned as a new “metabolic organ”. Recent studies with intestinal microbiology have shown that microbiota is associated with both metabolic and cardiovascular diseases. Intestinal microbiota associated with many diseases has made it possible to use microbiota modification in therapy. The modification of the intestinal microbiota with products like probiotic, prebiotic and symbiotic becomes increasingly important treatment method.

Anahtar Kelimeler

Intestinal microbiota, cardiovasculer disease, alter the gut microbiota

Kardiyovasküler Hastalıklar ve Mikrobiyota

Öz

Kardiyovasküler Hastalıklar (KVH) dünya genelinde ölümlerin en sık nedenidir. Dünyadaki tüm ölümlerin %31’ini oluşturmaktadır. KVH için sigara kullanımı, sağlıksız beslenme, obezite, fi ziksel inaktivite, yüksek kan basıncı (hipertansiyon), yüksek kan yağları ve diyabet gibi risk faktörleri mevcuttur Vücudun deri, ağız, vajina, bağırsaklar gibi çeşitli bölgelerinde yerleşmiş bakterilere o bölgenin “florası”, yeni adıyla “mikrobiyota”sı denmektedir. Mikroorganizmaların genomuna ise “mikrobiyom” adı verilmektedir. İnsan vücudu %10 kendi hücresi ve % 90’ı mevcut konağa yerleşmiş mikrobiya hücrelerden oluşmaktadır. İntestinal mikrobiyota; vücudumuzda fi zyolojik, metabolik ve immun sistem üzerinde oldukça önemli görevler üstlenmektedir. Enerji taşıyıcı rolü üstlenerek veya immun modüle edici maddeleri serbest bırakarak gerekli metabolik süreçleri kontrol eden bağırsak bakterileri bu nedenle günümüzde yeni bir “metabolik organ” olarak tanımlanmaktadır. Bağırsak Mikrobiyotası ile son dönemde yapılan çalışmalarda Mikrobiyota ile hem metabolik hem de kardiyovasküler hastalıklar arasında ilişki olduğu gösterilmiştir İntestinal mikrobiyotanın birçok hastalıkla ilişkili bulunması mikrobiyota modifi kasyonunun tedavide kullanılabilirliğini gündeme getirmiştir.İntestinal mikrobiyotanın probiyotik, prebiyotik ve simbiyotik gibi ürünlerle modifi ye edilmesi giderek önem kazanan tedavi yöntemi olmaktadır.

Anahtar Kelimeler

İntestinal mikrobiyota, kardiyovasküler hastalıklar, Mikrobiyota düzenlenmesi

Kaynakça

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