Subklinik Hipotiroiditli Çocuklarda Ağız Sağlığı Durumunun Değerlendirilmesi

Yıl 2019, Cilt: 3 Sayı: 3, 237 - 244, 31.12.2019

Nuray Tüloğlu , Tuğçe Kaliçoğlu Birgül Kırel

https://doi.org/10.34084/bshr.640291

Öz

Amaç: Bu
araştırmada, subklinik hipotiroiditli çocuk hastaların ağız sağlığı durumunun
değerlendirilmesi ve sağlıklı çocuklarla karşılaştırılması amaçlandı.

Yöntem: Araştırmaya
4-18 yaş aralığındaki 36’sı subklinik hipotiroiditli (deney grubu), 36’sı
sağlıklı (kontrol grubu) toplam 72 çocuk dahil edildi. Araştırmaya dahil edilen
çocukların ağız sağlığı durumunun belirlemek için DMFT/dft indeksi, gingival
indeks, plak indeksi kullanıldı. Elde edilen verilerin istatistiksel analizlerinde
2 yönlü varyans analizi (two-way ANOVA) ve Bonferroni testi kullanıldı.

Bulgular:
Deney grubunun DMFT değerlerinin kontrol grubundan daha yüksek olduğu ancak
aradaki farkın sadece 13-18 yaş grubunda istatistiksel olarak anlamlı olduğu
belirlendi (p<0.05). Plak indeksi ve gingival indeks skorları açısından
kontrol ve deney grubu arasında anlamlı bir fark olmadığı tespit edildi
(p>0.05).

Sonuç:
Subklinik hipotiroiditli çocuk hastalarda diş çürüğü görülme sıklığının
sağlıklı çocuklara oranla daha yüksek olduğu ancak periodontal sağlığın
etkilenmediği belirlendi. Bununla birlikte, bulgularımızın desteklenmesi için
daha geniş popülasyonlu çalışmaların yapılması gerektiği kanısındayız.  

Anahtar Kelimeler

Çocuk, Diş çürüğü, Subklinik hipotiroidi, Periodontal sağlık

Destekleyen Kurum

Eskişehir Osmangazi Üniversitesi Bilimsel Araştırma Projeleri Komisyonu

Proje Numarası

2017-45A233

Teşekkür

Bu araştırma Eskişehir Osmangazi Üniversitesi Bilimsel Araştırma Projeleri Komisyonu tarafından 2017-45A233 proje numarası ile desteklenmiştir.

Evaluation of Oral Health Status of Children with Subclinical Hypothyroidism

Öz

Objective: To assess and compare the oral health status of children suffering from subclinical

hypothyroidism and healthy children.

Methods: A total of 72 children, 36 with subclinical hypothyroiditis (experimental group) and

36 healthy controls (control group) were included in the study. DMFT/dft index, gingival index,

and plaque index were used to determine the oral health status of the children included in the

study. Two-way ANOVA and Bonferroni test were used for statistical analysis of the obtained

data.

Results: It was determined that DMFT values of the experimental group were higher than the

control group but the statistically significant difference was only observed in the 13-18 age

group (p <0.05). It was detected that there was no significant difference between the control

and experimental groups in terms of plaque index, and gingival index scores.

Conclusion: It was determined that the prevalance of dental caries in children with subclinical

hypothyroidism was higher than in healthy children, but periodontal health was not affected.

However, we believe that larger population studies should be carried out to support our findings.

Anahtar Kelimeler

Child, Dental caries, Subclinical hypothyroidism, Periodontal health

Proje Numarası

2017-45A233

Kaynakça

• 1. Cooper DS. Clinical practice. Subclinical hypothyroidism. N Engl J Med. 2001; 345(4): 260-265.
• 2. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2): 228-238.
• 3. Adlin V. Subclinical hypothyroidism: deciding when to treat. Am Fam Physician. 1998; 57(4): 776-780.
• 4. Wiersinga WM. Adult Hypothyroidism. In: Leslie J De Groot, ed. Thyroid Manager. Online books. 2013. Published in http://www.thyroidmanager.org/
• 5. Kim YA, Park YJ. Prevalence and risk factors of subclinical thyroid disease. Endocrinol Metab (Seoul). 2014; 29(1): 20-29.
• 6. Yürekli BŞ, Kabalak T, Altıner S. Subklinik hipotiroidi meselesi: tedavi edilmeli mi edilmemeli mi?. Türkiye Klinikleri J Endocrin. 2016; 11(2): 55-64.
• 7. Rivolta G, Cerutti R, Colombo R, et al. Prevalence of subclinical hypothyroidism in a population living in the Milan metropolitan area. J Endocrinol Invest. 1999; 22(9): 693-697.
• 8. Canaris GJ, Manowitz NR, Mayor G, et al. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000; 160(4): 526-534.
• 9. Bona G, Prodam F, Monzani A. Subclinical hypothyroidism in children: natural history and when to treat. J Clin Res Pediatr Endocrinol. 2013; 5(Suppl 1): 23-28.
• 10. Baldini IM, Vita A, Mauri MC, et al. Psychopathological and cognitive features in subclinical hypothyroidism. Prog Neuropsychopharmacol Biol Psychiatry. 1997; 21(6): 925-935.
• 11. Devdhar M, Ousman YH, Burman KD. Hypothyroidism. Endocrinol Metab Clin North Am. 2007; 36(3): 595-615.
• 12. Chang CP, Shiau YC, Wang JJ, et al. Decreased salivary gland function in patients with autoimmune thyroiditis. Head Neck. 2003; 25(2): 132-137.
• 13. Lo Muzio L, Santarelli A, Campisi G, et al. Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found. Clin Oral Investig. 2013; 17(1): 333-336.
• 14. Agha-Hosseini F, Shirzad N, Moosavi MS. Evaluation of Xerostomia and salivary flow rate in Hashimoto's Thyroiditis. Med Oral Patol Oral Cir Bucal. 2016; 21(1): e1-5.
• 15. Venkatesh Babu NS, Patel PB. Oral health status of children suffering from thyroid disorders. J Indian Soc Pedod Prev Dent. 2016; 34(2): 139-144.
• 16. Syed YA, Reddy BS, Ramamurthy TK, et al. Estimation of salivary parameters among autoimmune thyroiditis patients. J Clin Diagn Res. 2017; 11(7): ZC01-ZC04.
• 17. Silness J, Löe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964; 22(1): 121-135.
• 18. Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol. 1967; 38(6): 610-616.
• 19. Genderson MW, Sischo L, Markowitz K, et al. An overview of children’s oral health-related quality of life assessment: from scale development to measuring outcomes. Caries Res. 2013 ;47(Suppl 1): 13-21.
• 20. Jeffcoat MK, Jeffcoat RL, Gladowski PA, et al. Impact of periodontal therapy on general health: evidence from insurance data for five systemic conditions. Am J Prev Med. 2014; 47(2): 166-174.
• 21. Carlos Fabue L, Jiménez Soriano Y, Sarrión Pérez MG. Dental management of patients with endocrine disorders. J Clin Exp Dent. 2010; 2(4): e196-203.
• 22. Desai MP. Disorders of thyroid gland in India. Indian J Pediatr. 1997; 64(1): 11-20.
• 23. Desai MP. Thyroid function in children. J Assoc Physicians India. 2011; 59(Suppl): 35-42.
• 24. Szanto A, Csipo I, Horvath I, et al. Autoantibodies to alfa-fodrin in patients with Hashimoto thyroiditis and Sjögren’s syndrome: possible markers for a common secretory disorder. Rheumatol Int. 2008; 28(11): 1169-1172.
• 25. Yılmaz AB, Orbak R, Çanakçı N, ve ark. Erzurum ve Düzce'de 6- 12 yaş grubu bireylerde CPITN, df, dmf indekslerini kullanarak periodontal hastalıklar ile diş çürüğünün değerlendirilmesi ve iki bölgenin karşılaştırılması. Atatürk Üniv Diş Hek Fak Derg. 1997; 7(1): 5-11.
• 26. Bodur H, Bodur A, Yücesoy V, ve ark. İki farklı yaş grubunda diş çürüğü prevelansı ve periodontal durumun değerlendirilmesi. Gazi Üniv Diş Hek Fak Derg. 2004; 21(5): 35-39.
• 27. Kambek Taşveren S, Yalçın Yeler D, Sözen A, ve ark. 12 yaş grubu çocukların diş fırçalama sıklığı-dmf-t ilişkisi. Atatürk Üniv Diş Hek Fak Derg. 2005; 15(3): 11-14.
• 28. Gökalp S, Güçiz Doğan B, Tekçiçek M, ve ark. Beş, on iki ve on beş yaş çocukların ağız diş sağlığı profili, Türkiye-2004. Hacettepe Diş Hek Fak Derg. 2007; 31(4): 3-10.
• 29. Koksal E, Tekcicek M, Yalcin SS, ve ark. Association between anthropometric measurements and dental caries in Turkish school children. Cent Eur J Public Health. 2011; 19(3): 147-151.
• 30. Beriashvili S, Nikolaishvili M, Mantskava M, et al. Changes in tooth hard tissue mineralization and blood rheology in healthy adolescents and those with thyroid dysfunction. Georgian Med News. 2016; (Issue): 28-34.
• 31. Persson RE, Persson GR, Kiyak HA, et al. Oral health and medical status in dentate low-income older persons. Spec Care Dentist. 1998; 18(2): 70-77.
• 32. Muralidharan D, Fareed N, Pradeep PV, et al. Qualitative and quantitative changes in saliva among patients with thyroid dysfunction prior to and following the treatment of the dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 115(5): 617-623.
• 33. Scardina GA, Messina P. Modifications of interdental papilla microcirculation: a possible cause of periodontal disease in Hashimoto's thyroiditis? Ann Anat. 2008; 190(3): 258-63.
• 34. Siqueira WL, Bermejo PR, Mustacchi Z, et al. Buffer capacity, pH and flow rate in saliva of children aged 2-60 months with down's syndrome. Clin Oral Investig. 2005; 9(1): 26-29.
• 35. Monea A, Elod N, Sitaru A, et al. Can thyroid dysfunction induce periodontal disease? Eur Sci J. 2014; 10(15): 74-83.
• 36. Al-Rubbaey YA, El-Samarrai SK. Oral health status and dental treatment needs in relation to salivary constituents and parameters among a group of patients with thyroid dysfunction. J Bagh College Dentistry. 2010; 22(1): 105-108.
• 37. Bartalena L, Grasso L, Brogioni S, et al. Serum interleukin-6 in amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab. 1994; 78(2): 423-427.
• 38. Sekeroglu MR, Altun ZB, Algün E, ve ark. Serum cytokines and bone metabolism in patients with thyroid dysfunction. Adv Ther. 2006; 23(3): 475-480.
• 39. De Toledo S, Bozo L, Do Nascimento A, et al. Changes of thyroid gland and periodontal tissues of marmosets related to experimental hypothyroidism. Rev Bras Pesqui Med Biol. 1979; 12(2-3): 141-146.
• 40. Feitosa DS, Marques MR, Casati MZ, et al. The influence of thyroid hormones on periodontitis-related bone loss and tooth supporting alveolar bone: A histological study in rats. J Periodontal Res. 2009; 44(4): 472-478.
• 41. Hanau KJ, Naoom E, Mahammed HO. CPITN in Iraqi females with thyroid dysfunction. Mustansiryia Dent J. 2018; 9(1): 99-106.