Lower Respiratory Tract Infection due to coinfection of Influenza A Virus and Human Metapneumovirus in A 4.5-Month-Old Infant With

Yıl 2020, Cilt: 4 Sayı: 1, 67 - 71, 30.04.2020

Ayşegül Pala , Öner Özdemir

https://doi.org/10.34084/bshr.714709

Öz

Lower respiratory tract infections (LRTI) are mostly caused by respiratory syncytial virus (RSV), influenza, parainfluenza, rhinovirus and adenovirus. In recent years human other viruses such as human metapneumovirus (hMPV), parainfluenza 4 and bocavirus also have been reported to cause LRTI. Coinfection of more than one virus in childhood can develop bronchiolitis in children. In this study, we report a case of bronchiolitis developed by coinfection of hMPV and influenza A viruses in a 4.5-month-old male baby who admitted to our hospital with the fever and cough.

Anahtar Kelimeler

human metapneumovirus, influenza A, coinfection, bronchiolitis

İnsan Metapnömovirüs’e İnfluenza A Virüsünün Eşlik Ettiği 4.5 Aylık Süt Çocuğunda Alt Solunum Yolu Enfeksiyonu

Öz

Alt solunum yolu enfeksiyonları (ASYE) çoğunlukla respiratuvar sinsisyal virüs (RSV), influenza, parainfluenza, rhinovirüs ve adenovirüs kaynaklıdır. Ancak, son yıllarda bu virüslere ek olarak insan metapnömovirüs (iMPV), parainfluenza 4 ve bocavirüs gibi virüslerinde ASYE’ye sebep olduğu gösterilmiştir. Çocukluk çağında birden fazla virüsün ko-enfeksiyonu ile bronşiolit geliştiği unutulmamalıdır. Bu çalışmamızda, ateş ve öksürük şikâyeti ile hastanemize başvuran 4.5 aylık erkek bir bebekte iki farklı virüsün (iMPV ve influenza A) ko-enfeksiyonu sonucu gelişen bronşiolit olgu sunumu anlatılmıştır.

Anahtar Kelimeler

human metapnömovirüs, infleunza A, koenfeksiyon, bronşiolit

Kaynakça

• 1. Pavia AT. Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis. 2011;52(4):S284-9.
• 2. Ozdemir O, Bircan O. Human Metapneumovirus Infection in a Patient with Recurrent Wheezing: Case Report. Istanbul Medical Journal, 2019. 20: p. 261-263.
• 3. Vinci A., Lee PJ, Krilov LR. Human Metapneumovirus Infection. Pediatrics in Review, 2018. 39(12): p. 623.
• 4. Simon A, Manoha C, Müller A, Schildgen O. Human Metapneumovirus and Its Role in Childhood Respiratory Infections. Current Pediatrics Reports, 2014;2(3): p. 156-165.
• 5. Kayıran, SM, Ercin S, Kayıran PG, Eroğlu E, Gümüş T, Gürakan B. A case of pneumonia due to co-infection with two different viruses. SETB, 2017. 51(4): p. 342-345.
• 6. Hilmes MA, Daniel Dunnavant F, Singh SP, Ellis WD, Payne DC, Zhu Y, et al. Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol. 2017;47(13):1745-1750.
• 7. Munoz FM. Seasonal influenza in children: Clinical features and diagnosis. In Mallory GB, Edwards, MS (eds). UpToDate Inc. https://www.uptodate.com/contents/seasonal-influenza-in-children-clinical-features-and-diagnosis (Accessed on January 13, 2020.)
• 8. Esposito S, Daleno C, Prunotto G, Scala A, Tagliabue C, Borzani I, et al. Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses. Influenza Other Respir Viruses 2013;7:18–26.Pilger DA, Cantarelli VV, Amantea SL, Leistner-Segal S. Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil. Memórias do Instituto Oswaldo Cruz, 2011. 106: p. 56-60.
• 9. Parsania M, Poopak B, Pouriayevali MH, Haghighi S, Amirkhani A, Nateghian A. Detection of Human Metapneumovirus and Respiratory Syncytial Virus by Real-Time Polymerase Chain Reaction Among Hospitalized Young Children in Iran. Jundishapur J Microbiol. 2016; 9(3): e32974.
• 10. Mizuta K, Abiko C, Aoki Y, Ikeda T, Matsuzaki Y, Itagaki T, et al. Seasonal Patterns of Respiratory Syncytial Virus, Influenza A Virus, Human Metapneumovirus, and Parainfluenza Virus Type 3 Infections on the Basis of Virus Isolation Data between 2004 and 2011 in Yamagata, Japan. Japanese Journal of Infectious Diseases. 2013;66(2):p. 140-145.
• 11. Bosis S, Esposito S, Niesters HG, Crovari P, Osterhaus AD, Principi N. Impact of human metapneumovirus in childhood: comparison with respiratory syncytial virus and influenza viruses. J Med Virol. 2005;75(1):101-4.
• 12. Lin TY, Huang YC, Tsao KC, Huang YL. Human metapneumovirus and community-acquired pneumonia in children. Chang Gung Med J. 2005;28: 683–8.
• 13. Ghattas C, Mossad SB. Fatal human metapneumovirus and influenza B virus coinfection in an allogeneic hematopoietic stem cell transplant recipient. Transpl Infect Dis. 2012;14:e41–3.