Synthesis, Characterization and Investigation of Antimicrobial Activities of Salts and Complexes Containing 2-Amino-5-Bromopyridine and Dipicolinic Acid

Yıl 2025, Cilt: 8 Sayı: 1, 1 - 12, 30.06.2025

Beyza Yılmaz , Halil İlkimen , Elif Yurt , Ayşe Polat , Aysel Gülbandılar

https://doi.org/10.55117/bufbd.1557419

Öz

The salt {(H2a5Brp)(Hpka), 1} of 2-amino-5-bromopyridine (2a5Brp) and dipicolinic acid (H2pka) and metal complexes of salt (1) {(H2a5Brp)[Fe(pka)2].2H2O (2), (H2a5Brp)2[Co(pka)2].4H2O (3), (H2a5Brp)2[Ni(pka)2].3H2O (4), (H2a5Brp)2[Cu(pka)2].2H2O (5)} were synthesized. Elements analysis, NMR, AAS, IR, UV, molar conductivity magnetic, and susceptibility procedures all showed the structures of 1–5. Spectroscopic investigation showed that every metal compound had an octahedral and ionic structure. All substances were tested for their antimicrobial properties against the following microorganisms: Candida albicans (ATCC 14053) (yeast), Bacillus subtilis, Listeria monocytogenes (ATCC 7644), Pseudomonas aeruginosa (ATCC 27853), Enterococcus faecalis (ATCC 29212), and Staphylococcus aureus (NRRL-B 767) bacteria. Results Of Antimicrobial Activity Were Contrasted With Those Of Ketoconazole, Fluconazole, Vancomycin, Cefepime, Chloramphenicol, and Levofloxacin. The findings of the activity indicated that the highest values were found 3 in C. albicans yeast, all compounds in E. coli bacteria, 1 and 2 in S. aureus bacteria, 2 in L. monocytogenes bacteria, 1 in B. subtilis bacteria, 2a5Brp, 1 and 2 in P. aeruginoa bacteria and all compounds (except 4 and 5) in E. faecalis bacteria.

Anahtar Kelimeler

Dipicolinic acid , 2-Amino-5-bromopyridine , Salt , Metal complex , Antimicrobial activity.

Proje Numarası

1919B012107941

2 Amino 5 bromopiridin ile Dipikolinik Asit İçeren Tuz ve Komplekslerinin Sentezi, Karakterizasyonu ve Antimikrobiyal Aktivitelerinin Araştırılması

Öz

2-Amino-5-bromopiridin (ap) ile dipikolinik asitin (H2pka) tuzu {(Hap)(Hpka), 1) ve tuzun metal kompleksleri {(Hap [Fe(pka)2].2H2O (2), (Hap)2[Co(pka)2].4H2O (3), (Hap)2[Ni(pka)2].3H2O (4), (Hap)2[Cu(pka)2].2H2O (5)} sentezlenmiştir. 1-5'in yapıları elementel analiz, NMR, AAS, IR, UV, molar iletkenlik ve manyetik duyarlılık yöntemleri ile önerilmiştir. Spektroskopik analiz sonucunda tüm metal komplekslerinin iyonik ve oktahedral yapıya sahip olduğu görülmüştür. Çalışmada kullanılan ve sentezlenen bileşiklerin Candida albicans (ATCC 14053) mayasına karşı antifungal, Bacillus subtilis, Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterococcus faecalis (ATCC 29212), Listeria monocytogenes (ATCC 7644) ve Staphylococcus aureus (NRRL-B 767) bakterilerine karşı antibakteriyel aktiviteleri incelenmiştir. Antifungal aktivite sonuçları Ketokonazol ve Flukonazol ile karşılaştırılırken, antibakteriyel aktiviteler Levofloksasin, Vankomisin, Kloramfenikol ve Sefepim ile karşılaştırılmıştır. Aktivite sonuçlarında en iyi değerler C. albicans mayasında 3, E. coli bakterisinde tüm bileşikler, S. aureus bakterisinde 1 ve 2, L. monocytogenes bakterisinde 2, B. subtilis bakterisinde 1, ap, P. aeruginoa bakterisinde 1 ve 2 ve E. faecalis bakterisinde ise tüm bileşiklerde (4 ve 5 hariç) gözlenmiştir.

Anahtar Kelimeler

Dipikolinik asit , 2-amino-5-bromopiridin , Tuz , Metal kompleksi , Antimikrobiyal aktivite.

Proje Numarası

1919B012107941

Teşekkür

Bu çalışma TÜBİTAK 2209-A Üniversite Öğrencileri Araştırma Projeleri Destekleme Programı kapsamında 1919B012107941 başvuru numarası ile desteklenmiştir.

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