The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos

Yıl 2018, , 51 - 55, 30.03.2018

Beyhan Gürcü , Tülay Oludağ Mete Fatih Çöllü İşıl Aydemir M. İbrahim Tuğlu

https://doi.org/10.18466/cbayarfbe.342317

Cited By: 2

Öz

Antiepileptic
drugs (AED) are teratogens that confer a risk of various congenital
malformations including neural tube defects. Lacosamide (LCM) is a novel
third-generation AED and its effects on neural tube (NT) development remain
unclear. Thus, the aim of the present study was to investigate the effects of
LCM in the early stages of NT development in the chicken embryo. Three
different doses of LCM were applied under the embryonic disks of chicken
embryos after they were incubated for 30 hours. Incubation was continued for an
additional 80 hours and then all embryos were obtained for routine histology. In
the LCM-treated groups, there was occlusion in the middle and ventral levels of
the cavity. In the group treated with 1.60 mg of LCM, the NT cavity was closed,
the notochord exhibited deterioration, and cellular association appeared
abnormal. In the groups treated with 0.12 and 0.5 mg of LCM, the ectoderm layer
surrounding the embryo was hypertrophic and the number of pyknotic cells
increased in a dose-dependent manner. Thus, different doses of LCM had
different effects. The results of this study demonstrated that LCM causes
histopathological alterations during the neurulation stage that might
ultimately result in the development of congenital defects and/or
malformations.

Anahtar Kelimeler

Lacosamide, Histopathology, Neural tube, Chick

Kaynakça

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