Characterization of Carotid Atherosclerotic Plaques by Measurement of Acoustic Impedance

Yıl 2018, , 321 - 325, 30.09.2018

Bükem Bilen , Ülkü Kafa , Mehmet Burçin Ünlü

https://doi.org/10.18466/cbayarfbe.442817

Öz

In
this study, acoustic properties of carotid atherosclerotic plaques are studied
ex vivo by scanning acoustic microscope (SAM). Human carotid atherosclerotic
plaques were collected from patients by carotid erdarterectomy operation
technique. An 80 MHz transducer was used in SAM, during the observation of the
plaques. For the fibrous tissue, acoustic impedance was measured as 2.02 ± 0.06 MRayl, while for the lipid pool it was
measured as 1.70 ± 0.07 MRayl and for the calcified region within
the intima it was measured as 2.23 ± 0.09 MRayl. The difference in acoustic
impedance values is due to the variation of elasticity within the
atherosclerotic plaques. Lipid pool, together with fibrous tissue and calcified
regions are the indications of vulnerable plaques, therefore, the determination
of these regions within the plaques by SAM will help to evaluate the risk of
thrombosis or stenosis and effect the decision making of the operations of the
patients.

Anahtar Kelimeler

Scanning acoustic microscopy, carotid artery, atherosclerosis, vulnerable plaque, acoustic impedance

Kaynakça

• 1. Bentzon, JF, Otsuka, F, Virmani, R, Falk, E, Mechanism of Plaque formation and Rupture, Circulation Research, 2014, 114, 1852-1866.
• 2. Insull, W, The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment, The American Journal of Medicine, 2009, 122(1A), S3-14.
• 3. Puri, R, Worthley, MI, Nicholls, SJ, Intravascular imaging of vulnerable coronary plaque: current and future concepts, Nature Reviews Cardiology, 2011, 8, 131-139.
• 4. Carlier, SG, Tanaka, K, Studying Coronary Plaque Regression with IVUS: A Critical Review of Recent Studies, Journal of Interventional Cardiology, 2016, 19(1), 11-15.
• 5. Li, J, Chen, Z, Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques, Journal of Biomedical Photonics and Engineering, 2016, 1(4), 209-224.
• 6. Jansen, K, Van Soest, G, Van Der Steen, AF, Intravascular photoacoustic imaging: a new tool for vulnerable plaque identification, Ultrasound in Medicine and Biology, 2014, 40(6), 1037-1048.
• 7. Wang, B, Su, JL, Karpiouk, AB, Intravascular Photoacoustic Imaging, IEEE Journal of Selected Topics in Quantum Electronics, 2010, 16(3), 599-599.
• 8. Yeager, D, Karpiouk, A, Wang, B, Amirian, J, Sokolov, K, Smalling, R, Emelianov, S, Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood, Journal of Biomedical Optics, 2012, 17(10), 106016.
• 9. Berer, T, Grun, H, Bauer-Marschallinger, J, Burgholzer, P, Passler, K, Nuster, R, Paltauf, G. In IEEE International Ultrasonics Symposium, Dresden, Germany, 2012, 10.1109/ULTSYM.2012.0356.
• 10. Kobayashi, K, Yoshida, S, Saijo, Y, Hozumi, N, Acoustic impedance microscopy for biological tissue characterization, Ultrasonics, 2014, 54, 1922–1928. 11. Hozumi, N, Nakano, A, Terauchi, S, Nagao, M, Yoshida, S, Kobayashi, K, Yamamoto, S, Saijo, Y. In IEEE International Ultrasonics Symposium, New York, NY, USA, 2007, 1051-0117/07.
• 12. De Korte, DL, Pasterkamp, G, Van Der Steen, AFW, Woutman, HA, Bom, N, Characterization of Plaque Components with Intravascular Ultrasound Elastography in Human Femoral and Coronory Arteries In Vitro, Circulation, 2000, 102(6), 617-623.
• 13. Virmani, R, Kolodgie, FD, Burke, AP, Farb A, Schwartz, SM, Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions, Arteriosclerosis, Thrombosis, and Vascular Biology, 2000, 20, 1262-1275.
• 14. Bailey, G, Meadows, J, Morrison, AR, Imaging Atherosclerotic Plaque Calcification: Translating Biology, Current Atherosclerosis Reports, 2016, 18, 51.
• 15. Vengrenyuk, Y, Carlier, S, Xanthos, S, Cardoso, L, Ganatos, P, Virmani, R, Einav, S, Gilchrist, L, Weinbaum, S, A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps, Proceedings of the National Academy of Sciences of the United States of America, 2006, 103, 14678-14683.
• 16. Shanahan, CM, Inflammation Ushers in Calcification A Cycle of Damage and Protection?, Circulation, 2007, 116, 2782-2785.
• 17. Aikawa, E, Nahrendorf, M, Figueiredo, JL, Swirski, FK, Shtatland, T, Kohler, RH, Farouc, AJ, Aikawa, M, Weissleder, R, Osteogenesis Associates With Inflammation in Early-Stage Atherosclerosis Evaluated by Molecular Imaging In Vivo, Circulation, 2007, 116, 2841-2850.
• 18. Saijo, Y, Ohashi, T, Sasaki, H, Sato, M, Jorgensen, CS, Nitta, S, Application of Scanning Acoustic Microscopy for Assessing Stress Distribution in Atherosclerotic Plaque, Annals of Biomedical Engineering, 2001, 29, 1048–1053.
• 19. Saijo, Y, Hozumi, N, Lee, C, Nagao, M, Kazuto, K, Oakada, N, Filho, ES, Sasaki, J, Tanaka, M, Yambe, T, Ultrasonic speed microscopy for imaging of coronary artery, Ultrasonics, 2006, 44, e51-e55.
• 20. Brewin, MP, Srodon, PD, Greenwald, SE, Birch, MJ, Carotid atherosclerotic plaque characterization by measurement of ultrasound sound speed in vitro at high frequency, 20 MHz, Ultrasonics, 2014, 54, 428-441.