Polarographic Determination of Lornoxicam in Pharmaceutical Formulations

Yıl 2009, Cilt: 5 Sayı: 1, 13 - 18, 01.03.2009

İbrahim Çetin Nisa Koçak Şule Aycan

https://izlik.org/JA33EW87YE

Öz

-

Anahtar Kelimeler

-

POLAROGRAPHIC DETERMINATION OF LORNOXICAM IN PHARMACEUTICAL FORMULATIONS - FARMASÖTİK FORMÜLLERDEKİ LORNOKSİKAMIN POLAROGRAFİK TAYİNİ

https://izlik.org/JA33EW87YE

Öz

POLAROGRAPHIC DETERMINATION OF LORNOXICAM IN PHARMACEUTICAL FORMULATIONS

A simple, precise, fast and low-cost differential pulse polarographic (DPP) method for
determination of lornoxicam in pharmaceutical formulations has been proposed. The results have been
compared with those of high performance liquid chromatography (HPLC) method. Mean values and
standard deviations calculated by ten determinations were 8.10 ± 0.12 mg for DPP and six determinations
were 8.02 ± 0.08 mg for the HPLC method. The statistical evaluations indicated that there was no significant
difference between the mean values and precessions of the two methods at 95% confidence level (t=2.64,
F=2.25)

FARMASÖTİK FORMÜLLERDEKİ LORNOKSİKAMIN POLAROGRAFİK TAYİNİ

Bu çalısmada farmasötik formüllerde bulunan lornoksikamı tayin etmek için basit, duyarlı, hızlı ve
ucuz bir yöntem önerilmistir. Bu yöntemle elde edilen sonuçlar yüksek performanslı sıvı kromatografisi
(HPLC) yöntemi ile elde edilenlerle karsılastırılmıstır. Tabletlerdeki lornoksikam miktarı için ortalama
degerler ve standart sapmalar diferansiyel puls polarografik (DPP) yöntem için on tayinle 8.10 ± 0.12 mg,
HPLC için altı tayinle 8.02 ± 0.08 mg olarak hesaplanmıstır. statistiksel degerlendirme, % 95 güvenirlik
düzeyinde bu iki yöntem arasında ortalama degerler ve duyarlık bakımından önemli bir fark olmadıgını
göstermistir (t=2.64, F=2.25).

Anahtar Kelimeler

Lornoksikam , Antienflamatuar , Polarografi

Kaynakça

• 1] Radhofer-Welte S., Dittrich P., “Determination of the novel non-steroidal antiinflammatory drug lornoxicam and its main metabolite in plasma and synovial fluid”, J. Chrom. B, 707: 151–159, 1998.
• [2] Atzpadien E., Mehdi N., Clarke D., et al., “Subacute and chronic oral toxicity of lornoxicam in cynnomolgus monkeys”, Food Anal. Chem. Toxicol., 35: 465–474, 1997.
• [3] Velpandian T., Jaiswal J., Bhardwaj R. K., “Gupta S. K., Development and validation of a new high-performance liquid chromatographic estimation method of meloxicam in biological samples”, J. Chrom. B, 738: 431–436, 2000.
• [4] Ozaltin N., “Differential pulse polarographic determination of tenoxicam in pharmaceuticals and added to blood”, Anal. Chim. Acta, 406: 183–189, 2000. [5] Altinoz S., Nemutlu E., Kir S., “Polarographic behaviour of meloxicam and its determination in tablet preparations and spiked plasma”, Il Farmaco, 57: 463–468, 2002.
• [6] Ghoneim M. M., Beltagi A. M., Radi, A., “Square-wave adsorptive stripping voltammetric determination of the anti-inflammatory drug lornoxicam”, Anal. Sci., 18[2]: 183–186, 2002.
• [7] Hein A., Norlander C., Blom L., et al., “Is pain pophylaxis in minor gynaecological surgery of clinical value? A double-blind placebo controlled study of paracetamol 1 g versus lornoxicam 8 mg given orally”, Ambulatory Surgery, 9[2]: 91–94, 2001.
• [8] Ozgur M. U., Aycan S., Islimyeli S., “Differential pulse polarographic determination of prazosin hydrochloride in tablets”, Die Pharmazie, 50: 435–436, 1995.
• [9] Ozgur M. U., Islimyeli S., Aycan S., “Differential pulse polarographic determination of doxasocin mesylate in tablets”, Die Pharmazie, 52[7]: 561–562, 1997.
• [10] Coskun N. Y., Aycan S., Sungur S., “Differential pulse polarographic determination of pravastatin sodium in tablets”, Die Pharmazie, 52[6]: 485–486, 1997.
• [11] Elmali F., Alpdogan G., Sungur S., Aycan S., “Polarographic determination of fluvoxamine maleate in tablets”, Turkish J. Chem., 24: 299– 302, 2000.
• [12] Elmali F., Alpdogan G., Aycan S., Sungur S., “Differential pulse polarographic determination of enalapril maleate”, Turkish J. Chem., 27: 65–69, 2003.