Araştırma Makalesi

Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis

Cilt: 17 Sayı: 4 29 Aralık 2021
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Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis

Öz

In this paper, the mathematical model which describes the glucose-insulin homeostasis in healthy rats is considered. The model is discretized by constructing a nonstandard finite difference (NSFD) scheme to obtain the numerical solutions. The equilibrium point of the discretized model is determined and stability analysis of the discretized model is discussed. The effect of time step sizes on 4th order Runge-Kutta method and NSFD method is presented. Also, comparison of NSFD scheme solution, Runge-Kutta-Fehlberg Method (RKF45) solution and analytical solution are presented in graphical form. The effectiveness of the proposed method in the solution and interpretation of the model is observed. Keywords: Glucose-Insulin homeostasis, nonstandard finite difference scheme, stability analysis.

Anahtar Kelimeler

Kaynakça

  1. 1. Chen, CL, Tsai, HW, Wong, SS. 2010. Modeling the physiological glucose–insulin dynamic system on diabetics. Journal of Theoretical Biology; 265: 314–322.
  2. 2. Dereouich, M, Boutayeb, A. 2002. The effect of physical exercise on the dynamics of glucose and insulin. Journal of Biomechanics; 35: 911–917.
  3. 3. Neatpisarnvanit, C, Boston, JR. 2002. Estimation of Plasma Insulin From Plasma Glucose. IEEE Transactions on biomedical engineering, 49(11): 1253-1259.
  4. 4. Li, J, Kuang,Y. Analysis of IVGTT glucose-insulin interaction models with time delay. 2001. Discrete and Continuous Dynamical Systems- Series B; 1(1): 103–124.
  5. 5. Hussain, J, Zadeng, D. 2014. A mathematical model of glucose-insulin interaction. Science Vision; 14(2): 84-88.
  6. 6. Wang, H, Li, J, Kuang, Y. 2007. Mathematical modeling and qualitative analysis of insulin therapies. Mathematical Biosciences; 210: 17–33.
  7. 7. Al-Kahby, H, Dannan, F, Elaydi, S. Non-standard Discretization Methods for Some Biological Models. 2000. Applications of Nonstandard Finite Difference Schemes; 155-180.
  8. 8. Mickens, RE. Difference Equations Theory and Applications, Atlanta, Ga, USA: Chapman & Hall, 1990.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Mühendislik

Bölüm

Araştırma Makalesi

Yayımlanma Tarihi

29 Aralık 2021

Gönderilme Tarihi

10 Aralık 2020

Kabul Tarihi

23 Kasım 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 17 Sayı: 4

Kaynak Göster

APA
Turhan Çetinkaya, İ., Kocabıyık, M., & Yakıt Ongun, M. (2021). Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis. Celal Bayar University Journal of Science, 17(4), 369-377. https://doi.org/10.18466/cbayarfbe.838451
AMA
1.Turhan Çetinkaya İ, Kocabıyık M, Yakıt Ongun M. Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis. Celal Bayar University Journal of Science. 2021;17(4):369-377. doi:10.18466/cbayarfbe.838451
Chicago
Turhan Çetinkaya, İlkem, Mehmet Kocabıyık, ve Mevlüde Yakıt Ongun. 2021. “Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis”. Celal Bayar University Journal of Science 17 (4): 369-77. https://doi.org/10.18466/cbayarfbe.838451.
EndNote
Turhan Çetinkaya İ, Kocabıyık M, Yakıt Ongun M (01 Aralık 2021) Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis. Celal Bayar University Journal of Science 17 4 369–377.
IEEE
[1]İ. Turhan Çetinkaya, M. Kocabıyık, ve M. Yakıt Ongun, “Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis”, Celal Bayar University Journal of Science, c. 17, sy 4, ss. 369–377, Ara. 2021, doi: 10.18466/cbayarfbe.838451.
ISNAD
Turhan Çetinkaya, İlkem - Kocabıyık, Mehmet - Yakıt Ongun, Mevlüde. “Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis”. Celal Bayar University Journal of Science 17/4 (01 Aralık 2021): 369-377. https://doi.org/10.18466/cbayarfbe.838451.
JAMA
1.Turhan Çetinkaya İ, Kocabıyık M, Yakıt Ongun M. Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis. Celal Bayar University Journal of Science. 2021;17:369–377.
MLA
Turhan Çetinkaya, İlkem, vd. “Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis”. Celal Bayar University Journal of Science, c. 17, sy 4, Aralık 2021, ss. 369-77, doi:10.18466/cbayarfbe.838451.
Vancouver
1.İlkem Turhan Çetinkaya, Mehmet Kocabıyık, Mevlüde Yakıt Ongun. Stability Analysis of Discretized Model of Glucose–Insulin Homeostasis. Celal Bayar University Journal of Science. 01 Aralık 2021;17(4):369-77. doi:10.18466/cbayarfbe.838451

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