Polarographic Determination of Lornoxicam in Pharmaceutical Formulations

Yıl 2009, Cilt: 5 Sayı: 1, 13 - 18, 01.03.2009

İbrahim Çetin Nisa Koçak Şule Aycan

Öz

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Anahtar Kelimeler

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POLAROGRAPHIC DETERMINATION OF LORNOXICAM IN PHARMACEUTICAL FORMULATIONS - FARMASÖTİK FORMÜLLERDEKİ LORNOKSİKAMIN POLAROGRAFİK TAYİNİ

Öz

POLAROGRAPHIC DETERMINATION OF LORNOXICAM IN PHARMACEUTICAL FORMULATIONS

A simple, precise, fast and low-cost differential pulse polarographic (DPP) method for
determination of lornoxicam in pharmaceutical formulations has been proposed. The results have been
compared with those of high performance liquid chromatography (HPLC) method. Mean values and
standard deviations calculated by ten determinations were 8.10 ± 0.12 mg for DPP and six determinations
were 8.02 ± 0.08 mg for the HPLC method. The statistical evaluations indicated that there was no significant
difference between the mean values and precessions of the two methods at 95% confidence level (t=2.64,
F=2.25)

FARMASÖTİK FORMÜLLERDEKİ LORNOKSİKAMIN POLAROGRAFİK TAYİNİ

Bu çalısmada farmasötik formüllerde bulunan lornoksikamı tayin etmek için basit, duyarlı, hızlı ve
ucuz bir yöntem önerilmistir. Bu yöntemle elde edilen sonuçlar yüksek performanslı sıvı kromatografisi
(HPLC) yöntemi ile elde edilenlerle karsılastırılmıstır. Tabletlerdeki lornoksikam miktarı için ortalama
degerler ve standart sapmalar diferansiyel puls polarografik (DPP) yöntem için on tayinle 8.10 ± 0.12 mg,
HPLC için altı tayinle 8.02 ± 0.08 mg olarak hesaplanmıstır. statistiksel degerlendirme, % 95 güvenirlik
düzeyinde bu iki yöntem arasında ortalama degerler ve duyarlık bakımından önemli bir fark olmadıgını
göstermistir (t=2.64, F=2.25).

Anahtar Kelimeler

Lornoksikam, Antienflamatuar, Polarografi

Kaynakça

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