A Hybrid Approach for Large-scale Fabrication of Paper-based Electrochemical Assays for Biomedical Diagnosis

Yıl 2019, Cilt: 15 Sayı: 3, 271 - 277, 30.09.2019

Fariba Ghaderinezhad Savas Tasoglu

https://doi.org/10.18466/cbayarfbe.542120

Öz

The electrochemical method offers a sensitive, portable, and
cost-effective method for detecting a range of analytes and has the capacity to
be miniaturized. However, according to the World Health Organization, there is
a need for point-of-care devices that meet the criteria for medical diagnostics
in remote and resource-limited regions, as set forth by the World Health
Organization. In this context, we developed a low-cost and high-throughput
method for fabricating paper-based devices for electrochemical assays using a
desktop pen plotter. In this study, we used a permanent marker to plot
hydrophobic barriers and a liquid dispenser to pattern three electrodes
(working, counter, and reference electrodes) with carbon paste on a paper
substrate. To test the performance of the fabricated electrochemical devices,
chronoamperometric and cyclic voltammetric analyses of potassium ferricyanide
was conducted. Further, to demonstrate of the possible biomedical diagnostic
applications, a quantitative glucose assay was performed. Here, we presented a
low-cost electrochemical device fabrication method convenient for large-scale
fabrication and widespread implementation of paper-based technologies in
developing countries and resource-limited settings.

Anahtar Kelimeler

pen plotter, paper-based assays, electrochemical, glucose assay, high-throughput, biosensor

Kaynakça

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