Long-Term Follow-up Results of Children with Urolithiasis Followed in Our Clinic

Yıl 2024, , 340 - 346, 30.09.2024

Esra Ensari , Esra Nagehan Akyol Onder , Pelin Ertan

https://doi.org/10.34087/cbusbed.1418142

Öz

Giriş ve Amaç: Ürolitiyazis, Türkiye'de çocuklarda sık rastlanan bir hastalıktır. Bu çalışmada, ürolitiyazisli çocukların klinik, radyolojik ve metabolik özellikleri üzerine bir değerlendirme yapılmıştır.
Gereç ve Yöntemler: 2010 ile 2020 yılları arasında Celal Bayar Üniversitesi Pediatrik Nefroloji Anabilim Dalı'na ürolitiyazis ve mikrolitiyazis şüphesiyle sevk edilen 158 çocuğun kayıtları geriye dönük tarandı. Olguların hastaneye başvurudaki şikayetleri ve yaşları, özgeçmiş öyküleri ve taşların lokasyonu belirlendi. Tüm hastalardan tam idrar tetkiki, spot idrar elektrolitleri, idrar kültürü, serum elektrolitleri, böbrek fonksiyon testleri, ürik asit, albümin ölçümleri ve üriner ultrasonografi istenildi. İdrar toplayabilen hastalarda 24 saatlik idrar elektrolitleri çalışıldı. Taş elde edilebilen hastalara X ışını ile difraksiyon yöntemiyle taş analizi yapıldı.
Bulgular: Çalışmada yer alan 158 çocuğun 88'i (%55.7) erkek, 70'i (%44.3) kız olup, erkek/kız oranı 1.25/1 olarak belirlendi. Ortalama tanı yaşı 89.82 ± 57.35 ay olarak saptandı. Bu hastaların 108'inde (%68.3) ailede ürolitiyazis öyküsü bulunmaktaydı. Ayrıca, 46 hasta (%29) akraba evliliğinden doğmuştu. Tanı anında 32 hastada (%20) idrar yolu enfeksiyonu tespit edildi. Hastaların 129'unda (%81.6) taşlar üst üriner sistemde bulunuyordu. Bunların 123'ünde (%77.8) taşlar tek taraflı iken, 35'inde (%22.2) bilateral taşlar mevcuttu. Taş analizi yapılan hastaların çoğunda (%80) kalsiyum oksalat taşları bulundu. En yaygın üriner metabolik risk faktörü ise hiperkalsiüri olarak belirlendi. Takip süresince 67 hasta taş hastalığından kurtulurken, 14 hastada nüks gözlendi.
Sonuç: Ülkemizde çocuklarda ürolitiazis ciddi bir sorun olarak devam etmektedir. Çocuklarda taş hastalıklarında erişkinlerden farklı olarak yüksek rekürrens oranı ve altta yatan metabolik bozuklukların daha sık olması nedeniyle metabolik değerlendirme ve taş analizi yapılmalı, ömür boyu takip gereği vurgulanmalıdır.

Anahtar Kelimeler

çocuk, ürolitiyazis, mikrolitiyazis, metabolik risk faktöleri

Etik Beyan

Çalışmamız, Helsinki Bildirgesi prensiplerine uygun olarak yürütülmüş olup, 24 Kasım 2021 tarihinde Celal Bayar Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu'ndan 20.478.486 protokol numarası ile etik onay alınmıştır.

Destekleyen Kurum

Bu araştırma, herhangi bir kamu, ticari veya kar amacı gütmeyen sektörden finansal destek almadı.

Long-Term Follow-up Results of Children with Urolithiasis Followed in Our Clinic

Öz

Title and Objective: Urolithiasis is a prevalent condition frequently observed in childhood within the Turkish population. The aim of this study was to evaluate the metabolic, radiological, and clinical features of pediatric patients with urolithiasis.
Materials and Methods: Records of 158 children referred to the Pediatric Nephrology Department of Celal Bayar University between 2010 and 2020 with suspected urolithiasis and microlithiasis were retrospectively reviewed. The complaints and ages of the cases during hospital admission, their medical histories, and the location of the stones were determined. All patients underwent complete urine analysis, spot urine electrolytes, urine culture, serum electrolytes, kidney function tests, uric acid, albumin measurements, and urinary ultrasonography. 24-hour urine electrolytes were studied in patients capable of urine collection. Stone analysis using X-ray diffraction was performed on patients from whom stones were obtained.
Results: Out of the individuals, 88 (55.7%) were male, and 70 (44.3%) were female, resulting in a male-to-female ratio of 1.25:1. The average age at the time of diagnosis was determined to be 89.82 ± 57.35 months. A family history of urolithiasis was reported in 108 (68.3%) patients, and 46 individuals (29%) were born from consanguineous marriages. At the time of diagnosis, 32 patients (20%) had a urinary tract infection. Stones were predominantly situated in the upper urinary system in 129 patients (81.6%), with 123 (77.8%) having unilateral stones and 35 (22.2%) having bilateral stones. Calcium oxalate stones were the most commonly observed (80%) in patients who underwent stone analysis. Hypercalciuria emerged as the most frequently identified urinary metabolic risk factor. At the end of the follow-up period, 14 patients experienced a recurrence, while 67 patients remained free of stones.
Conclusion: Urolithiasis continues to be a significant concern among children in our nation. Due to the higher recurrence rate and more frequent underlying metabolic disorders in children with stone diseases compared to adults, metabolic assessment and stone analysis are recommended procedures, emphasizing the need for lifelong monitoring in these cases.

Anahtar Kelimeler

child, urolithiasis, microlithiasis, metabolic risk factors

Etik Beyan

Our study was conducted in compliance with the Helsinki Declaration principles and obtained ethical approval from the Celal Bayar University Faculty of Medicine Clinical Research Ethics Committee on November 24, 2021, with protocol number 20.478.486.

Destekleyen Kurum

This research did not receive any financial support from public, commercial, or non-profit sectors.

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