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KRONİK HEPATİT C'Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER

Yıl 2015, Cilt: 2 Sayı: 1, 11 - 15, 11.07.2015

Tahir Buran

Öz

Hepatit C enfeksiyonu seyrinde meydana gelen ekstrahepatik bulguların; dolaşan immun komplekslere bağlı olduğu bildirilmiştir. Bunun direkt sitopatik ya da sitotoksik T hücre aracılığı ile olabileceği belirtilmişse de ortaya çıkan doku hasarının mekanizması hakkında çok az şey bilinmektedir . Ortaya çıkan ekstrahepatik bulgulardan esansiyel miks kriyoglobulinemi (EMC), Porfiria kutana tarda (PCT), Membranoproliferatif glomerulonefrit (MPG) ile HCV arasında güçlü; Mooren korneal ülser, otoimmün troidit ile muhtemel; Sjögren sendromu, liken planus, idyopatik pulmoner fibrozis, idyopatik trombositopenik purpura, aplastik anemi, RF, diabetes mellitus, vaskülit ve astma ile zayıf bir ilişki olduğu saptanmıştır.

Anahtar Kelimeler

Kronik hepatit C immünolojik göstergeler

Kaynakça

  • Ökten A, Türkoğlu S, Akkiz H, Şentürk H. HCV enfeksiyonu. Viral Hepatit. 2001;179-213.
  • Sherlock S, Dooley S.: Disease of the liver and Biliary System. Ninth edition, Blackwell scientific publication. 1993.p. 293-319.
  • Beşirbellioğlu B, Görenek L, Gül C, Hacıbektaşoğlu A. Hepatit C virüs enfeksiyonlu hastalarda oto antikor seroprevalansı. Klinik Bilimler-Doctor Dergisi. 1999;5(1):30- 35.
  • Bayraktar Y, Bayraktar M, Gürakar A, et al. A comparison of the prevalance of autoantibodies in individuals with chronic hepatitis C and those with autoimmun hepatitis: The role of interferon in the development of autoimmune diseases. Hepato-gastroenterology. 1997;417-425.
  • Topalak Ö, Batur Y.: HCV enfeksiyonu ve hematolojik değişiklikler. Güncel Gastroenteroloji. 1998;55-63.
  • Ueda K, Nakajima H, Nakagava I, Shimizu A. The association between hepatitis C virüs infection and invitro activation of
  • the complement system. Ann Clin Biochem 1993;30:565-569. 7. Samuel DG, Rees IW. Ekstrahepatic manifestations of
  • hepatitis C virüs. Gastroenterol.2013;4(4):249-254.
  • Dolar E. Kronik hepatit C virüs enfeksiyonunda ortaya çıkan renal ve immünolojik anormallikler. Viral hepatit dergisi 1998(1):9-11.
  • Cacoub P, Poynard T, Ghillani P, et al. Extrahepatic manifestations of chronic hepatitis C. Arthrıtıs and Rheumatısm. 1999;42:10:2204-2212.
  • Warren NS, Jack TS, Douglas RL, et al. Hepatitis c virüs(HCV) infectionand Cryoglobulinemia, Analysis of whole Blood and Plasma HCV-RNA concentrations and correlation with Liver Histology. Hepatology 2000;31(3):1-1
  • Zaja F, De Vita S, Mazzaro C, et al. Efficacy and safety of rituximab in tip 2 mixed cryoglobulinaemia vasculitis. Curr Opin Rheumatol. 2008;20:23-8.
  • İoetrogarande M, De vita S, Zignego Al, et al. Recommendations
  • cryoglobulinaemia syndrome in hepatitis C virüs-infected patients. Autoimmun Rev. 2011;10:444-54.
  • Ferri C, Cacoub P, Mazzaro C, Roccatello D, et. al. Treatment with
  • mixed cryoglobulinemia syndrome: results of multicenter cohort study and review of the literature .Autoimmun Rev. 2011;11(1):48-55.
  • Hadzıyannıs SJ. Bonhepatic manifestations and combined disease and Sciences. 1996;41:12.
  • Weiner SM, Berg T, Bertholl H, et al. A clinical and virological study of hepatitis C virüs-related cryoglobulinemia in germany. J Hepatol 1998;29(3):375-384.
  • Marson P. Extrahepatic manifestations of HCV infection. Minerva med. 1995;86(7-8):305-314
  • Pivetti S, Navarino A, Merico F, et al. High prevalence of otoimmune phenomena in hepatitis c virüs antibody positive patients with lymphoproliferative and connective tissue disorders. Britis Journal of Heamotology. 1996;95:204-211.
  • Dickson RC, Gaffey MJ, İshitani MB, Roarty TP, Driscoll CJ, Caldwell SH. İnternational autoimmun hepatitis score in chronic hepatitis C. J viral Hepat. 1997;482:121-128
  • Bushenfelde M. Immunopathology of chronic liver diseases. Verh Dtsch pathol. 1995;79:186-197
  • Lohse AW, gerken G, Mohr H, et al. Relation beetween autoimmune liver diseases and viral hepatitis: clinical and serological characterstics in 859 patients. Z gastroenterol. 1995;9:527-533
  • Ignatova TM, Aprosina ZG, Serov VV et al. Extrahepatic manifestations of chronic hepatitis C. Ter Arkh. 1998; 70(11):9-16.
  • Itoh K, tanaka H, Shiga J. Hipocomplementemia associated with hepatitis C viremia in sera from voluntary bloods donors. Am. J. Gastroenterol. 1994; 898(ll): 2019-2024.
  • Akahane Y, Miyanaki Y, Naitoh S. et al. Cold activation of coCplement for monitoring the response to interferon in patients with Chronic hepatitis C. Am J Gastroenterol. 1996;92(2):319-322.
  • Daoud MS, el-Azhary RA, Gibson LE, et al. Chronic hepatitis C, Cryoglobulinemia, and cutaneous necrotising vasculitis. Clinical, pathologic and immunopathologic study of twelve patiends. J AM management of
  • mixed 13. rituximab in patients
  • with 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. http://edergi.cbu.edu.tr/ojs/index.php/cbusbed isimli yazarın
  • CBU-SBED başlıklı eseri bu Creative Commons Alıntı
  • Gayriticari 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Yıl 2015, Cilt: 2 Sayı: 1, 11 - 15, 11.07.2015

Tahir Buran

Öz

Extrahepatic findings occurred in the course of hepatitis C infection; It was reported to be due to circulating immune complexes. It is reported to be through direct cytopathic or cytotoxic T cells is known very little about the mechanisms of tissue damage occurs. The resulting findings of extrahepatic essential mixed cryoglobulinemia (EMC), cutaneous porphyria tarda (PCT), membranoproliferative glomerulonephritis (MPG) with strong between HCV; Mooren corneal ulcer, autoimmune likely to troidit; Sjögren's syndrome, lichen planus, idiopathic pulmonary fibrosis, idiopathic thrombocytopenic purpura, aplastic anemia, RF, diabetes mellitus, vasculitis, and was found to be a weak association with asthma.

Anahtar Kelimeler

Chronic hepatitis C immunological marker

Kaynakça

  • Ökten A, Türkoğlu S, Akkiz H, Şentürk H. HCV enfeksiyonu. Viral Hepatit. 2001;179-213.
  • Sherlock S, Dooley S.: Disease of the liver and Biliary System. Ninth edition, Blackwell scientific publication. 1993.p. 293-319.
  • Beşirbellioğlu B, Görenek L, Gül C, Hacıbektaşoğlu A. Hepatit C virüs enfeksiyonlu hastalarda oto antikor seroprevalansı. Klinik Bilimler-Doctor Dergisi. 1999;5(1):30- 35.
  • Bayraktar Y, Bayraktar M, Gürakar A, et al. A comparison of the prevalance of autoantibodies in individuals with chronic hepatitis C and those with autoimmun hepatitis: The role of interferon in the development of autoimmune diseases. Hepato-gastroenterology. 1997;417-425.
  • Topalak Ö, Batur Y.: HCV enfeksiyonu ve hematolojik değişiklikler. Güncel Gastroenteroloji. 1998;55-63.
  • Ueda K, Nakajima H, Nakagava I, Shimizu A. The association between hepatitis C virüs infection and invitro activation of
  • the complement system. Ann Clin Biochem 1993;30:565-569. 7. Samuel DG, Rees IW. Ekstrahepatic manifestations of
  • hepatitis C virüs. Gastroenterol.2013;4(4):249-254.
  • Dolar E. Kronik hepatit C virüs enfeksiyonunda ortaya çıkan renal ve immünolojik anormallikler. Viral hepatit dergisi 1998(1):9-11.
  • Cacoub P, Poynard T, Ghillani P, et al. Extrahepatic manifestations of chronic hepatitis C. Arthrıtıs and Rheumatısm. 1999;42:10:2204-2212.
  • Warren NS, Jack TS, Douglas RL, et al. Hepatitis c virüs(HCV) infectionand Cryoglobulinemia, Analysis of whole Blood and Plasma HCV-RNA concentrations and correlation with Liver Histology. Hepatology 2000;31(3):1-1
  • Zaja F, De Vita S, Mazzaro C, et al. Efficacy and safety of rituximab in tip 2 mixed cryoglobulinaemia vasculitis. Curr Opin Rheumatol. 2008;20:23-8.
  • İoetrogarande M, De vita S, Zignego Al, et al. Recommendations
  • cryoglobulinaemia syndrome in hepatitis C virüs-infected patients. Autoimmun Rev. 2011;10:444-54.
  • Ferri C, Cacoub P, Mazzaro C, Roccatello D, et. al. Treatment with
  • mixed cryoglobulinemia syndrome: results of multicenter cohort study and review of the literature .Autoimmun Rev. 2011;11(1):48-55.
  • Hadzıyannıs SJ. Bonhepatic manifestations and combined disease and Sciences. 1996;41:12.
  • Weiner SM, Berg T, Bertholl H, et al. A clinical and virological study of hepatitis C virüs-related cryoglobulinemia in germany. J Hepatol 1998;29(3):375-384.
  • Marson P. Extrahepatic manifestations of HCV infection. Minerva med. 1995;86(7-8):305-314
  • Pivetti S, Navarino A, Merico F, et al. High prevalence of otoimmune phenomena in hepatitis c virüs antibody positive patients with lymphoproliferative and connective tissue disorders. Britis Journal of Heamotology. 1996;95:204-211.
  • Dickson RC, Gaffey MJ, İshitani MB, Roarty TP, Driscoll CJ, Caldwell SH. İnternational autoimmun hepatitis score in chronic hepatitis C. J viral Hepat. 1997;482:121-128
  • Bushenfelde M. Immunopathology of chronic liver diseases. Verh Dtsch pathol. 1995;79:186-197
  • Lohse AW, gerken G, Mohr H, et al. Relation beetween autoimmune liver diseases and viral hepatitis: clinical and serological characterstics in 859 patients. Z gastroenterol. 1995;9:527-533
  • Ignatova TM, Aprosina ZG, Serov VV et al. Extrahepatic manifestations of chronic hepatitis C. Ter Arkh. 1998; 70(11):9-16.
  • Itoh K, tanaka H, Shiga J. Hipocomplementemia associated with hepatitis C viremia in sera from voluntary bloods donors. Am. J. Gastroenterol. 1994; 898(ll): 2019-2024.
  • Akahane Y, Miyanaki Y, Naitoh S. et al. Cold activation of coCplement for monitoring the response to interferon in patients with Chronic hepatitis C. Am J Gastroenterol. 1996;92(2):319-322.
  • Daoud MS, el-Azhary RA, Gibson LE, et al. Chronic hepatitis C, Cryoglobulinemia, and cutaneous necrotising vasculitis. Clinical, pathologic and immunopathologic study of twelve patiends. J AM management of
  • mixed 13. rituximab in patients
  • with 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. http://edergi.cbu.edu.tr/ojs/index.php/cbusbed isimli yazarın
  • CBU-SBED başlıklı eseri bu Creative Commons Alıntı
  • Gayriticari 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA46UJ52US
Bölüm Makaleler
Yazarlar

Tahir Buran Bu kişi benim

Yayımlanma Tarihi 11 Temmuz 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 2 Sayı: 1

Kaynak Göster

APA Buran, T. (2015). KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 2(1), 11-15.
AMA Buran T. KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER. CBU-SBED. Temmuz 2015;2(1):11-15.
Chicago Buran, Tahir. “KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 2, sy. 1 (Temmuz 2015): 11-15.
EndNote Buran T (01 Temmuz 2015) KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 2 1 11–15.
IEEE T. Buran, “KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER”, CBU-SBED, c. 2, sy. 1, ss. 11–15, 2015.
ISNAD Buran, Tahir. “KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 2/1 (Temmuz 2015), 11-15.
JAMA Buran T. KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER. CBU-SBED. 2015;2:11–15.
MLA Buran, Tahir. “KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 2, sy. 1, 2015, ss. 11-15.
Vancouver Buran T. KRONİK HEPATİT C’Lİ HASTALARDA İMMÜNOLOJİK GÖSTERGELER. CBU-SBED. 2015;2(1):11-5.