İRRİTABLE BARSAK SENDROMLU HASTALARDA QT DİSPERSİYONUNUN DEĞERLENDİRLMESİ

Yıl 2018, Cilt: 5 Sayı: 2, 33 - 37, 29.06.2018

Umut Payza , Zeynep Karakaya , Fatih Topal , Firdevs Topal , Pınar Akyol

Öz

Amaç: Ortak embiriyolojik bağları nedeniyle
irritable barsak sendromu (İBS) olan hastalarda kardiyak etkilenmeyi
değerlendirmek ve QT, QTc, QTd,
QTcd
ile ilişkili intervalde olan değişiklikleri araştırmak.

Metod: Çalışma prospektif olarak çalışıldı.
Çalışmaya 01.01.2016-31.12.2018 yılları arasında irritable barsak sendrom
tanısı almış 96 hasta dahil edildi. Ayrıca 100 sağlıklı gönüllü ile bir kontrol
grubu oluşturuldu. Acil servisimize bu hastalar davet edilerek elektrokardiyogramları
çekildi. Hastalarda ve gönüllülerde düzeltilmiş QT süreleri ve QT
dispersiyonları Bazzet formülü kullanılarak hesaplandı.

Bulgular: Çalışmaya katılan irritable barsak
sendromu tanısı olan gönüllü erkeklerin yaş ortalaması 47,9 ve kadınların ise
40,2 idi. Sağlıklı gönüllülerde kadınların yaş ortalaması 40.7, erkeklerin ise
43.6 idi. Hastaların yaş ortalaması da QT ve QTc’de her hangi bir uzama
görülmezken, QTd ve QTcd değerlerinde sağlıklı gönüllülere kıyasla uzama olduğu
görüldü.

Sonuç: Sağlıklı gönüllüler ile irritable
barsak sendromu tanısı olan hastalar arasında QT ve QTC intervalinde uzama
anlamlı olmamasına rağmen QTd ve QTcd anlamlı derecede uzama olduğu görüldü.

Tartışma: Bizim çalışmamız bu hastaların
düzeltilmiş QTd ve QTcd dispersiyonları olduğunu gösterdi. Bu sebeple irritable
barsak sendromu olan hastalar için acil servislerde kullanılacak veya reçete
edilecek ilaçların dikkatli seçilmesi gerekliliğini ortaya koyduk.

Anahtar Kelimeler

İrritable barsak sendromu, QT dispersiyonu, acil servis, akılcı ilaç kullanımı

EVALUATION OF QT DISPERSION WITH IRRITABLE BOWEL SYNDROME PATIENTS;

Öz

ABSTRACT;

Objectives; Because of common origin in
the embryonic development in patients with Irrıtable bowel syndrome(IBS),
evaluation of cardiac affects and changes of associated with QT,QTc,QTd and
QTcd intervals.

Materials and methods: This study
worked as prospectively. 100 patients included to this study who had diagnosed
IBS in 2016-2018. Also control group has formed with 100 healty volunteer.
These patients was invited to our emergency room for taking their
electrocardiograms.Corrected QT intervals and QT dispersion calculated with
Bazzet Formula in both IBS patients and volunteers.

Results: 86 IBS patients and 92 healty
volunteers included in our study.Average age was 47.9 in men and 40.2 in
women.Average age in healty volunteers 40.7,43.6 was in men.Theres no extension
in QT and QTc intervals in average age in patients;but there is more extension in
QTd and QTcd intervals with IBS patients than healty volunteers.

Conclusion: Although the extension in
the QT and QTc intervals between healty volunteers and patients with IBS
patients is not significant ; QTd anf QTcd were significantly prolonged.

Dicussıon: Our study showed  that these patients had corrected QTd and
QTcd dispersions.Just because of this choosing right medical drugs was
important for IBS patients.

Anahtar Kelimeler

irritable bowel syndrome, QT dispersions, emergency room, rational drug choice

Kaynakça

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