Knowledge And Attitudes Towards Genetic Testing In Those Affected With Chronic Diseases

Yıl 2020, Cilt: 7 Sayı: 2, 212 - 218, 30.06.2020

Selim Altan Sırrı Çam

https://doi.org/10.34087/cbusbed.723900

Öz

Backround
Genetics is increasingly penetrating modern medicine. It should be investigated whether there is a relationship between knowledge and attitude in developing Muslim countries.
Objectives
This study aims to investigate the relationship between the genetic information levels of individuals with a chronic disease and their attitudes towards genetic testing.
Method
This cross - sectional study was carried out between individuals with one and / or more chronic diseases living in rural and urban areas were included in the study. Participants were asked to complete the questionnaire forms.
Results
346 people participated in the study, and their mean age was 55.99 years. The level of Genetic Knowledge of the participants was very low, and the majority (about 80%) gave the wrong answers to almost all of the related questions. The mean scores of attitudes and genetic information of the participants in urban areas compared to those living in rural areas were found to be higher. In addition, it was found that they had more positive attitudes towards genetics tests and genetics.
Conclusions
Although it is thought that individuals with chronic diseases are experts in their diseases, it is understood that this is not the case in genetics. This result seems to be due to lack of knowledge rather than being closed to genetic developments. In addition, the study revealed that the fatalistic approach in a Muslim society was not decisive in the approach to genetic testing; therefore, it is important to pay attention to these issues when planning genetic health services.

Anahtar Kelimeler

Genetic tests, , Chronic diseases, , Attitude

Destekleyen Kurum

Celal Bayar Üniversitesi Bilimsel Araştırmaları Projelerini Destekleme Fonu

Proje Numarası

2017-176

Kaynakça

• Referans 1 WHO. Preventing chronic diseases : a vital investment. [Internet]. Vita-Finzi L, editor. Geneva: World Health Organization; 2005. 182 p. [cited 2019 Feb 4]. Available from: https://app.luminpdf.com/viewer/9hMT7hpbL47HWFMDj
• Referans 2 WHO. GLOBAL STATUS REPORT on noncommunicable diseases 201 4 "Attaining the nine global noncommunicable diseases targets; a shared responsibility"Geneva; 2014. [cited 2019 Feb 4]. Available from: http://apps.who.int/iris/bitstream/handle/10665/148114/9789241564854_eng.pdf;jsessionid=2700014C4A829DFCC74F432DAF43F7F0?sequence=1
• Referans 3 Chokoshvili D, Belmans C, Poncelet R, Sanders S, Vaes D, Vears D, et al. Public Views on Genetics and Genetic Testing: A Survey of the General Public in Belgium. Genetic Testing and Molecular Biomarkers. 2017;21(3):195–201.
• Referans 4 U.S. National Library of Medicine. What is genetic testing? [cited 2019 Feb 4]. Available from: https://ghr.nlm.nih.gov/primer/testing/genetictesting
• Referans 5 WHO. Medical genetic services in developing countries The Ethical, Legal and Social Implications of genetic testing and screening Human Genetics Chronic Diseases and Health Promotion World Health Organization. Geneva; 2006. [cited 2019 Feb 4]. Available from: http://apps.who.int/iris/bitstream/handle/10665/43288/924159344X_eng.pdf?sequence=1&isAllowed=y
• Referans 6 Fagbemiro L, Adebamowo C. Knowledge and attitudes to personal genomics testing for complex diseases among Nigerians. BMC medical ethics. 2014;15(1):34.
• Referans 7 Evans JP, Skrzynia C, Burke W. The complexities of predictive genetic testing. BMJ (Clinical research ed). British Medical Journal Publishing Group; 2001 Apr 28;322(7293):1052–6.
• Referans 8 Zimmern RL. Issues concerning the evaluation and regulation of predictive genetic testing. Journal of community genetics. 2014;5(1):49–57.
• Referans 9 Wauters A, Van Hoyweghen I. Global trends on fears and concerns of genetic discrimination: a systematic literature review. Journal of Human Genetics. 2016;61(4):275–82.
• Referans 10 Scuffham TM, McInerny-Leo A, Ng S-K, Mellick G. Knowledge and attitudes towards genetic testing in those affected with Parkinson’s disease. Journal of Community Genetics. 2014;5(2):167–77.
• Referans 11 Shen J. Precision assessment of public attitudes toward genetic testing. American Journal of Medical Genetics Part A. 2016;170(12):3185–8.
• Referans 12 Akdağ R. Türkiye Sağlıkta Dönüşüm Programı Değerlendirme Raporu (2003-2011) T.C. Sağlık Bakanlığı - E-Kütüphane Sistemi. 2011. [cited 2019 Feb 4]. Available from: https://sbu.saglik.gov.tr/Ekutuphane/Yayin/453
• Referans 13 Alwan A, D R MacLean, L M Riley, E T d’Espaignet, C D Mathers, G A Stevens, D Bettcher Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries. Lancet 2010; 376: 1861–68
• Referans 14 Tekşen F. The investigation of couples whom admitted by spontaneous abortion. Tıp Sağlık Dergisi. 2000;4(4):50–3.
• Referans 15 Tekşen F. The concerns of a section of Moslem-Turkish women towards prenatal diagnosis. J of BWW Society. 2002;3(1):1–7.
• Referans 16 Erdem Y, Tekşen F. Genetic screening services provided in Turkey. Journal of Genetic Counseling. 2013;22(6):858–64.
• Referans 17 Edisan Zehra AS. The right not to know in the field of genetic applications. Türkiye Klinikleri Tıp Etiği-Hukuku-Tarihi Dergisi. Turkiye Klinikleri; 2007;15(3):211.
• Referans 18 Berkman BE. Refuting the Right Not to Know. Journal of Healthcare Law and Policy 2017; 19(1): 1-75.
• Referans 19 Henneman L, Vermeulen E, Carla G van EI, Claassen L, Timmermans D RM, Cornel M C. Public attitudes towards genetic testing revisited: comparing opinions between 2002 and 2010 European Journal of Human Genetics (2013) 21, 793–799
• Referans 20 Lim Q, McGill BC, Quinn VF, Tucker KM, Mizrahi D, Patenaude AF, et al. Parents’ attitudes toward genetic testing of children for health conditions: A systematic review. Clinical Genetics. 2017;92(6):569–78.
• Referans 21 Korlaar IM, Vossen CY, Rosendaal FR, Bovill EG, Naud S, Cameron LD, et al. Attitudes toward genetic testing for thrombophilia in asymptomatic members of a large family with heritable protein C deficiency. Journal of Thrombosis and Haemostasis. 2005;3(11):2437–44.
• Referans 22 Güler B, Esra Manav, Emin Uğurlu. Medicinal plants used by traditional healers in Bozüyük (Bilecik–Turkey). Journal of Ethnopharmacology 2015;173(15):39-47
• Referans 23 Oliveri S, Masiero M, Arnaboldi P, Cutica I, Fioretti C, Pravettoni G. Health Orientation, Knowledge, and Attitudes toward Genetic Testing and Personalized Genomic Services: Preliminary Data from an Italian Sample. BioMed Research International. 2016;2016:1–9.
• Referans 24 Vermeulen E, Henneman L, van El CG, Cornel MC. Public attitudes towards preventive genomics and personal interest in genetic testing to prevent disease: a survey study. The European Journal of Public Health. 2014;24(5):768–75.
• Referans 25 Etchegary H, Cappelli M, Potter B, Vloet M, Graham I, Walker M, et al. Attitude and Knowledge about Genetics and Genetic Testing. Public Health Genomics. 2010;13(2):80–8.
• Referans 26 Bryant LD, Ahmed S, Ahmed M, Jafri H, Raashid Y. ‘All is done by Allah’. Understandings of Down syndrome and prenatal testing in Pakistan. Social Science & Medicine. Pergamon; 2011;72(8):1393–9.
• Referans 27 Pivetti M, Melotti G. Prenatal Genetic Testing: An Investigation of Determining Factors Affecting the Decision-Making Process. Journal of Genetic Counseling. 2013;22(1):76–89.
• Referans 28 Lea D, Williams J, Donahue M. Ethical Issues in Genetic Testing. Journal of Midwifery & Women’s Health. 2005;50(3):234–40.
• Referans 29 Roberts JS, Uhlmann WR. Genetic susceptibility testing for neurodegenerative diseases: Ethical and practice issues. Progress in Neurobiology. 2013;110:89–101.
• Referans 30 Fulda KG, Lykens K. Ethical issues in predictive genetic testing: a public health perspective. Journal of Medical Ethics. 2006;32(3):143–7.
• Referans 31 Shoenbill K, Fost N, Tachinardi U, Mendonca EA. Genetic data and electronic health records: a discussion of ethical, logistical and technological considerations. Journal of the American Medical Informatics Association. 2014;21(1):171–80.