Evaluation of migraine without aura patients by visual evoked potentials with different spatial frequencies

Yıl 2020, Cilt: 7 Sayı: 4, 454 - 459, 31.12.2020

Ceyla Ataç , Ezgi Tuna

https://doi.org/10.34087/cbusbed.728608

Öz

Giriş ve Amaç: Çalışmamızın amacı, International Society for Clinical Electrophysiology of Vision (ISCEV) standartlarına göre, aurasız migren hastalarında, iki farklı kontrol boyutu (15 've 62') ile kaydedilen tersine çevrilmiş görsel uyarılmış potansiyellerindeki (PVEP'ler) değişiklikleri interiktal dönemde incelemektir.
Gereç ve Yötemler: Hastaların demografik verileri; hastalık süresi, baş ağrısı özellikleri, bir aydaki atak sayısı, ortalama atak süresi, baş ağrısına eşlik eden şikayetler, baş ağrısının ortalama şiddeti gibi hastaların baş ağrısı günlüklerinden görsel analog ölçeğe göre belgelendi. Aurası olmayan yirmi migren hastası ve 14 sağlıklı gönüllü, iki farklı kontrol boyutuyla (15 ’ve 62’) kaydedilen PVEP'ler ile incelendi. Stimülasyon sekansları hem dama tahtasının kontrol boyutu hem de stimülasyon tarafı (sağ-15 ', sağ-62', sol-15 ', sol-62') için randomize edildi. N75, P100 gecikmesi ve N75-P100'ün tepeden tepeye genliği analiz edildi.
Bulgular: Her iki kontrol boyutu için PVEP sonuçlarının latans ve amplitüdleri açısından sağlıklı kişiler ile aurasız migren hastaları arasında istatistiksel olarak fark yoktu (p> 0,05).
Sonuç: Aurasız migren hastalarında, farklı spatyal frekanslara sahip PVEP'ler ile magnoselüler yol disfonksiyonunu tespit etmedik. Daha geniş hasta grupları ve PVEP'leri psikofiziksel testlerle birleştiren çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Aurasız migren, patern tersine dönme-VEP, uzaysal frekans

Evaluation of migraine without aura patients by visual evoked potentials with different spatial frequencies

Öz

Objective: The objective of our study was to investigate changes in pattern reversal visual evoked potentials (PVEPs) of migraine without aura patients recorded with two different check sizes (15’ and 62’) in accordance with International Society for Clinical Electrophysiology of Vision (ISCEV) standards during the interictal period.
Materials and Methods: Patients' demographic data were documented from headache diaries of patients, such as duration of disease, headache characteristics, the number of attacks in a month, the average duration of attacks, complaints accompanying headache, mean severity of headache according to visual analog scale. Twenty migraine patients without aura and 14 healthy volunteers were examined with PVEPs recorded with two different check-sizes (15’ and 62’). The stimulation sequences were randomized both for the check-size of checkerboard and the side of stimulation (right-15', right-62', left-15', left-62'). The latency of N75, P100 and peak-to-peak amplitude of N75-P100
were analyzed.
Results: There were no statistical difference between healthy subjects and migraine without aura patients in the means of latency and amplitude of PVEPs results for both check-sizes (p>0,05).
Conclusion: In migraine patients without aura, we did not detect magnocellular pathway dysfunction by PVEPs with different spatial frequencies. Studies on larger patient groups and combining PVEPs with psychophysical tests are needed.

Anahtar Kelimeler

Migraine without aura, pattern reversal-VEP, spatial frequency

Kaynakça

• REFERENCES: 1. Whatham AR, Nguyen V, Zhu Y, Hannessy M, Kalloniatis M. The value of electrophysiology in the assesment of eye and the visual system in the era of advanced imaging. Clinical and Experimental Optometry, 2014, 97(2), 99-115.
• 2. Bradley, W.G et al. Neurology in Clinical Practice (2008) In: Emerson RG, Pedley TA (ed) Clinical Neurophysiology. 5th edn. Butterworth-Heinemann/Elsevier in Philadelphia, PA, 2008, pp 481-453.
• 3. Spreafico C, Frigerio R, Santoro P, Ferrarese C, Agostoni E. Visual evoked potentials in migraine, Neurological Sciences, 2004, 25 (Suppl 3), 288-90.
• 4. Brinciotti M, Guidetti V, Matricardi M, Cortesi F. Responsiveness of the visual system in childhood migraine studied by means of VEPs. Cephalalgia, 1986, 6(3), 183–185.
• 5. Mariani E, Moschini V, Pastorino G et al, Pattern-reversal visual evoked potentials and EEG correlations in common migraine patients, 1988, Headache, 28(4), 269–271.
• 6. Lai CW, Dean P, Ziegler DK, Hassanein RS, Clinical and electrophysiological responses to dietary challenge in migraineurs, 1989, Headache, 29(3), 180–186.
• 7. Drake ME, Pakalnis A, Hietter SA, Padamadan H, Visual and auditory evoked potentials in migraine. Electromyography Clinical Neurophysiology, 1990, 30(2), 77–81.
• 8. Schoenen J, Wang W, Albert A, Delwaide PJ, Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks, European Journal of Neurology, 1995, 2(2), 115–122. 9. Rossi LN, Pastorino GC, Bellettini G et al, Pattern reversal visual evoked potentials in children with migraine or tension-type headache, Cephalalgia, 1996, 16, 104–106 .
• 10. Sener HO, Haktanir I, Demirci S (1997) Pattern-reversal visual evoked potentials in migraineurs with or without visual aura. Headache 37:449–451
• 11. Polich J, Ehlers CL, Dalessio DJ, Pattern-shift visual evoked responses and EEG in migraine, Headache, 1986, 26(9), 451–456.
• 12.Tagliati M, Sabbadini M, Bernardi G, Silvestrini M, Multichannel visual evoked potentials in migraine. Electroencephalography and Clinical Neurophysiology, 1995, 96(1), 1–5.
• 13. Kennard C, Gawel M, Rudolph N, Rose FC, Visual evoked potentials in migraine subjects, Research and clinical studies in headache, 1978, 6, 73–80.
• 14. Raudino F, Visual evoked potential in patients with migraine, Headache, 1988, 28, 531–533.
• 15. Sand T, White L.R, Hagen K, Stovner L.J. Visual evoked potential and spatial frequency in migraine: a longitudinal study. Acta Neurology Scandinavia, 2009, 120 Suppl (189), 33–37.
• 16. Oelkers R, Grosser K, Lang E, Geisslinger G, Kobal G, Brune K, Lötsch J. Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency, .Brain. 1999, 122 (Pt 6), 1147-55. 17. Ambrosini A, Schoenen J. Electrophysiological response patterns of primary sensory cortices in migraine. Journal of Headache Pain, 2006, 7(6), 377-388.
• 18. Sıngh R, Kotharı R, Sıngh S, Bokarıya P. Effect of check size on visual evoked potentials in normal healthy subjects of central İndia, Journal of Mahatma Gandhi Institute of Medical Sciences, 2010, 15, 64-69.
• 19. Ambrosini A, de Noordhout AM, Sandor PS, Schoenen J. Electrophysiological studies in migraine: a comprehensive review of their interest and limitations, Cephalalgia., 2003, 23 (Suppl. 1), 13-31.
• 20. Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Tormene AP, Mizota A, ISCEV standard for clinical visual evoked potentials, (2016  update), Documenta Ophthalmologica, 2016, 133(1), 1-9.
•  21. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition (beta version), Cephalalgia, 2013, 33, 629-808.
• 22. Hawker GA, Mian S, Kendzerska T, French M. Measures of Adult Pain. Arthritis Care & Research, 2011, 63 Suppl (11), 240-252.
• 23. Di Russo F., Pitzalis S., Spitoni G., Aprile T., Patria F., Spinelli D., Hillyard S.A. Identification of the neural sources of the pattern-reversal vep., Neuroimage, 2005, 24(3):874–886.
• 24. Foxe J.J., Strugstad E.C., Sehatpour P., Molholm S., Pasieka W., Schroeder C.E., McCourt M.E. Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential: high-density electrical mapping of the “C1” component. Brain Topography, 2008, 21(1), 11–21.
• 25. Vanni S., Warnking J., Dojat M., Delon-Martin C., Bullier J., Segebarth C. Sequence of pattern onset responses in the human visual areas: an fMRI constrained VEP source analysis., Neuroimage, 2004, 21(3), 801–817.
• 26. Chronicle E, Mulleners W. Might migraine damage the brain ? Cephalalgia 1994;14:415-8.
• 27. Lewis RA,Vijayan N, Watson C, Keltner J, Johnson CA. Visual field loss in migraine, Ophthalmology, 1989, 96(3), 321-6.
• 28. McKendrick AM, Badcock DR. An analysis of the factors associated with visual field deficits measured with flickering stimuli in-between migraine, Cephalalgia, 2004, 24(5), 389-97.