In the last decade, with the increase in cases of chronic non-communicable diseases such as obesity, diabetes and dyslipidemia, interest in the use of probiotics and prebiotics as complementary or adjuvant therapy has increased. Kefir is a fermented product rich in probiotic content. Studies conducted in the last decade were examined and compiled to examine the effects of kefir, a fermented product rich in probiotic content, on diabetes. When the results are evaluated, it is stated in the studies examined that kefir consumed daily in different doses and for different periods of time provides good glycemic control and metabolic control. The aim of this review study is to shed light on the effects of kefir produced using different milk types and different bacterial strains on human health in different dimensions (such as the central nervous system) and the effects of kefir on criteria such as shelf life in future studies.
Derleme çalışması olması sebebiyle etik kurul başvurusu yapılmamıştır.
Destekleyen Kurum
Yoktur
Kaynakça
Acik, M., Çakıroğlu, F.P., Altan, M. & Baybo, T. (2020). Alternative source of probiotics for lactose intolerance and vegan individuals: sugary kefir. Food Science and Technology, 40, 523-531.
Akar, F., Sumlu, E., Alçığır, M.E., Bostancı, A. & Sadi, G. (2021). Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats. Food Research International, 143, 110287.
Aydar, E.F., Tutuncu, S. & Ozcelik, B. (2020). Plant-based milk substitutes: Bioactive compounds, conventional and novel processes, bioavailability studies, and health effects. Journal of Functional Foods, 70, 103975.
Barboza, K.R.M., Coco, L.Z., Alves, G.M., Peters, B., Vasquez, E.C, … Campagnaro, B.P. (2018). Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. Life Sciences, 209, 370–376.
Baud, D., Dimopoulou Agri, V., Gibson, G.R., Reid, G. & Giannoni, E. (2020). Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic. Frontiers in Public Health, 8, 186.
Bellikci-Koyu, E., Sarer-Yurekli, B.P., Akyon, Y., Aydin-Kose, F., Karagozlu, C., … Buyuktuncer, Z. (2019). Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study. Nutrients, 11, 2089.
Bengoa, A., Iraporda, C., Garrote, G.L. & Abraham, A.G. (2018). Kefir micro-organisms: Their role in grain assembly and health properties of fermented milk. Journal of Applied Microbiology, 126(3), 686–700.
Berbudi, A., Rahmadika, N., Tjahjadi, A.I. & Ruslami, R. (2020). Type 2 diabetes and its impact on the immune system. Current Diabetes Reviews, 16, 442.
Bourrie, B.C.T., Willing, B.P. & Cotter, P.D. (2016). The microbiota and health promoting characteristics of the fermented beverage kefir. Frontiers in Microbiology, 7, 647.
Brown, L., Caligiuri, S.P.B., Brown, D. & Pierce, G.N. (2018). Clinical trials using functional foods provide unique challenges. Journal of Functional Foods, 45, 233–238.
Chait, A. & Den Hartigh, L.J. (2020). Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Frontiers in cardiovascular medicine, 7, 22.
Chen, Y.H., Chen, H.L., Fan, H.C., Tung, Y.T., Kuo, C.W., … Chen, C.M. (2020).
Anti-Inflammatory, Antioxidant, and Antifibrotic Effects of Kefir Peptides on Salt-Induced Renal Vascular Damage and Dysfunction in Aged Stroke-Prone Spontaneously Hypertensive Rats. Antioxidants, 9, 790.
Chourasia, R., Padhi, S., Chiring Phukon, L., Abedin, M.M., Singh, S.P. & Rai, A.K. (2020). A Potential Peptide from Soy Cheese Produced Using Lactobacillus delbrueckii WS4 for Effective Inhibition of SARS-CoV-2 Main Protease and S1 Glycoprotein. Frontiers in Molecular Biosciences, 7, 601753.
Costa, G.M., Paula, M.M., Costa, G.N., Esmerino, E.A., Silva, R., … Pimentel, T. (2020). Preferred attribute elicitation methodology compared to conventional descriptive analysis: a study using probiotic yogurt sweetened with xylitol and added with prebiotic components. Journal of Sensory Studies, 35(6), e12602.
Culpepper, T. (2022). The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review. Cureus, 14(8), e27768.
Demirci, A.S., Palabiyik, I., Ozalp, S. & Tirpanci Sivri G. (2019). Effect of using kefir in the formulation of traditional Tarhana. Food Science and Technology, 39(2), 358-364.
Di Renzo, T., Reale, A., Boscaino, F. & Messia, M.C. (2018). Flavoring production in Kamut®, quinoa and wheat doughs fermented by Lactobacillus paracasei, Lactobacillus plantarum, and Lactobacillus brevis: a SPME-GC/MS study. Frontiers in Microbiology, 9, 429.
Dos Santos, D.C., De Oliveira Filho, J.G., Santana, A.C.A., De Freitas, B.S.M., Silva, F.G., … Egea, M.B. (2019). Optimization of soymilk fermentation with kefir and the addition of inulin: Physicochemical, sensory and technological characteristics. LWT, 104, 30-37.
Egea, M.B., Santos, D.C.D., Oliveira Filho, J.G.D., Ores, J.D.C., … Lemes, A.C. (2022). A review of nondairy kefir products: their characteristics and potential human health benefits. Critical Reviews in Food Science and Nutrition, (6), 1536-1552.
Farag, M.A., Jomaa, S.A., Abd El-Wahed, A. & El-Seedi, H.R. (2020). The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety. Nutrients, 12, 346.
Ficara, M., Pietrella, E., Spada, C., Della Casa Muttini, E., Lucaccioni, L., … Berardi, A. (2020). Changes of intestinal microbiota in early life. The Journal of Maternal-Fetal & Neonatal Medicine, 33(6), 1036-1043.
Flynn, J., Ryan, A. & Hudson, S.P. (2021). Pre-Formulation and Delivery Strategies for the Development of Bacteriocins as Next Generation Antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 165, 149-163.
Guzel-Seydim, Z.B., Gokirmaklı, C. & Greene, A.K. (2021). A comparison of milk kefir and water kefir: Physical, chemical, microbiological and functional properties. Trends in Food Science & Technology, 113, 42–53.
Gao, W. & Zhang, L. (2019). Comparative analysis of the microbial community composition between Tibetan kefir grains and milks. Food Research International, 116, 137–144.
Garofalo, C., Ferrocino, I., Reale, A., Sabbatini, R., Milanović, V., … Osimani, A. (2020). Study of kefir drinks produced by backslopping method using kefir grains from Bosnia and Gul, O., Atalar, I., Mortas, M. & Dervisoglu, M. (2018). Rheological, textural, colour and sensorial properties of kefir produced with buffalo milk using kefir grains and starter culture: A comparison with cows’ milk kefir. International Journal of Dairy Technology, 71, 73–80.
Herzegovina: Microbial dynamics and volatilome profile. Food Research International, 137, 109369.
Hamida, R.S., Shami, A., Ali, M.A., Almohawes, Z.N., Mohammed, A.E., Bin-Meferij, M.M. (2021). Kefir: A protective dietary supplementation against viral infection. Biomedicine & Pharmacotherapy, 133, 110974.
Hikmetoglu, M., Sogut, E., Sogut, O., Gokirmakli, C. & Guzel-Seydim, Z.B. (2020). Changes in carbohydrate profile in kefir fermentation. Bioactive Carbohydrates and Dietary Fibre, 23, 100220.
Ilıkkan, Ö.K. & Bağdat E Ş. (2021). Comparison of bacterial and fungal biodiversity of Turkish kefir grains with high-throughput metagenomic analysis. LWT, 152, 112375.
Judacewski, P., Los, P.R., Lima, L.S., Alberti, A., Zielinski, A.A.F. & Nogueira A. (2019). Perceptions of Brazilian consumers regarding white mould surface‐ripened cheese using free word association. International Journal of Dairy Technology, 72(4), 585-590.
Judiono, J., Hadisaputro, S., Indranila, K., Cahyono, B., Suzery, M., … Purnawan, A.I. (2014). Effects of clear kefir on biomolecular aspects of glycemic status of type 2 diabetes mellitus (T2DM) patients in Bandung, West Java [study on human blood glucose, c peptide and insulin]. Functional Foods in Health and Disease, 4, 340–348.
Kang, E.A., Choi, H.I., Hong, S.W., Kang, S., Jegal, H.Y., … Kim, J.S. (2020). Extracellular vesicles derived from kefir grain Lactobacillus ameliorate intestinal inflammation via regulation of proinflammatory pathway and tight junction integrity. Biomedicines, 8(11), 522.
Karaçalı, R., Özdemir, N.İ. & Çon, A.H. (2018). Aromatic and functional aspects of kefir produced using soya milk and Bifidobacterium species. International Journal of Dairy Technology, 71(4), 921-933.
Khan, R.A.A., Najeeb, S., Mao, Z., Ling, J., Yang, Y., Li, Y. & Xie, B. (2020). Bioactive secondary metabolites from Trichoderma spp. against phytopathogenic bacteria and root-knot nematode. Microorganisms, 8(3), 401.
Kim, H., Sitarik, A.R., Woodcroft, K., Johnson, C.C. & Zoratti, E. (2019). Birth mode, breastfeeding, pet exposure, and antibiotic use: associations with the gut microbiome and sensitization in children. Current Allergy and Asthma Reports, 19, 1-9.
Kivanc, M. & Yapici, E. (2019). Survival of Escherichia coli O157: H7 and Staphylococcus aureus during the fermentation and storage of kefir. Food Science and Technology, 39(Suppl. 1), 225-230.
Lim, J., Kale, M., Kim, D.H., Kim, H.S., Chon, J.W.,… Kim, H. (2017). Antiobesity effect of exopolysaccharides isolated from kefir grains. Journal of Agricultural and Food Chemistry, 65(46), 10011-10019.
Lima, J.E., Moreira, N.C. & Sakamoto-Hojo, E.T. (2022). Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia. Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 874, 503437.
Lynch, K.M., Wilkinson, S., Daenen, L. & Arendt, E.K. (2021). An update on water kefir: Microbiology, composition and production. International Journal of Food Microbiology, 345, 109128.
Matos, R.S., Lopes, G.A.C., Ferreira, N.S., Pinto, E.P., Carvalho, J.C.T, Figueiredo, S.S., … Zamora, R.R.M. (2018). Superficial Characterization of Kefir Biofilms Associated with Açaí and Cupuaçu Extracts. Arab. International Journal of Engineering Science, 43, 3371–3379.
Maoloni, A., Milanović, V., Cardinali, F., Mangia, N.P., Murgia, M.A.,… Aquilanti, L. (2020). Bacterial and fungal communities of Gioddu as revealed by PCR–DGGE analysis. Indian Journal of Microbiology, 60(1), 119-123.
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., … Ventura, M. (2017). The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiology and molecular biology reviews, 81(4), e00036-17.
Mitra, S. & Ghosh, B.C. (2020). Quality characteristics of kefir as a carrier for probiotic Lactobacillus rhamnosus GG. International Journal of Dairy Technology, 73(2), 384-391.
Petrova, P., Ivanov, I., Tsigoriyna, L., Valcheva, N., Vasileva, E., … Petrov, K. (2021). Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits. Microorganisms, 9, 480.
Noureldein, M.H., Bitar, S., Youssef, N., Azar, S., Eid, A. A. (2020). Butyrate modulates diabetes-linked gut dysbiosis: epigenetic and mechanistic modifications. Journal of Molecular Endocrinology, 64(1), 29-42.
Ostadrahimi, A., Taghizadeh, A., Mobasseri, M., Farrin, N., Payahoo, L., … Vahedjabbari, M. (2015). Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Iranian journal of public Health, 44(2), 228.
Peluzio, M.D.C.G, Dias, M.D.M.E., Martinez, J.A. & Milagro, F.I. (2021). Kefir and intestinal microbiota modulation: implications in human health. Frontiers in Nutrition, 8, 638740.
Principi, N. & Esposito, S. (2016). Antibiotic administration and the development of obesity in children. International Journal of Antimicrobial Agents, 47(3), 171-177.
Seo, M.K., Park, E.J., Ko, S.Y., Choi, E.W. & Kim, S. (2018). Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease. Journal of Dairy Science, 101(10), 8662-8671.
Sindi, A., Badsha, M.B. & Unlu, G. (2020). Bacterial Populations in International Artisanal Kefirs. Microorganisms, 8, 1318.
Sivamaruthi, B.S., Kesika, P., Prasanth, M.I. & Chaiyasut, C. (2018). A mini review on antidiabetic properties of fermented foods. Nutrients, 10, 1973.
Terpou, A. (2020). Ethnic Selected Fermented Foods of Greece. In: Sankaranarayanan N A, Dhanasekaran D, editors. In Fermented Food Products. 1st ed. CRC Press: London, UK; Taylor & Francis Group: New York, NY, USA.
Tomar, O., Akarca, G., Çağlar, A., Beykaya, M., & Gök, V. (2020). The effects of kefir grain and starter culture on kefir produced from cow and buffalo milk during storage periods. Food Science and Technology, 40(1), 238-244.
Verma, J. & Subbarao, N. (2021). A comparative study of human betacoronavirus spike proteins: Structure, function and therapeutics. Archives of Virology, 166, 697–714.
Vieira, C.P., Rosario, A.I.L., Lelis, C.A., Rekowsky, B.S.S., Carvalho, A.P.A., … Conte-Junior, C.A. (2021). Bioactive compounds from kefir and their potential benefits on health: A systematic review and meta-analysis. Oxidative Medicine and Cellular Longevity, 1-34.
Yilmaz-Ersan, L., Ozcan, T., Akpinar-Bayizit, A. & Sahin, S. (2018). Comparison of antioxidant capacity of cow and ewe milk kefirs. Journal of Dairy Science, 101, 3788–3798.
Zheng, J., Wittouck, S., Salvetti, E., Franz, C.M., Harris, H.M., Lebeer S. (2020). A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. Journal of Systematic and Evolutionary Microbiology, 70(4), 2782-2858.
Xu, Y., Wang, N., Tan, H.Y., Li, S., Zhang, C., Feng, Y. (2020). Function of Akkermansia muciniphila in obesity: interactions with lipid metabolism, immune response and gut systems. Frontiers in microbiology, 11, 219.
Özet
Son on yılda obezite, diyabet, dislipidemi gibi kronik bulaşıcı olmayan hastalık vakalarındaki artışla birlikte tamamlayıcı veya adjuvan tedavi olarak probiyotik ve prebiyotik kullanımına ilgi artmıştır. Kefir probiyotik içeriği zengin fermente bir üründür. Probiyotik içeriği zengin bir fermente ürün olan kefirin diyabet üzerindeki etkileri incelemek amacıyla son on yılda yapılan çalışmalar incelenmiş ve derlenmiştir. Sonuçlar değerlendirildiğinde farklı dozlarda ve farklı sürelerde günlük olarak tüketilen kefirin iyi bir glisemik kontrol ve metabolik kontrol sağlayıcı olduğu incelenen çalışmalarda belirtilmektedir. Yapılan bu derleme çalışması ile hedeflenen ileriki çalışmalarda farklı süt türleri ve farklı bakteri suşları kullanılarak üretilen kefirlerin insan sağlığının farklı boyutlardaki etkilerinin incelenmesine (merkezi sinir sistemi gibi) ve kefirin raf ömrü gibi kriterlerine etkisine ışık tutması amaçlanmaktadır.
Acik, M., Çakıroğlu, F.P., Altan, M. & Baybo, T. (2020). Alternative source of probiotics for lactose intolerance and vegan individuals: sugary kefir. Food Science and Technology, 40, 523-531.
Akar, F., Sumlu, E., Alçığır, M.E., Bostancı, A. & Sadi, G. (2021). Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats. Food Research International, 143, 110287.
Aydar, E.F., Tutuncu, S. & Ozcelik, B. (2020). Plant-based milk substitutes: Bioactive compounds, conventional and novel processes, bioavailability studies, and health effects. Journal of Functional Foods, 70, 103975.
Barboza, K.R.M., Coco, L.Z., Alves, G.M., Peters, B., Vasquez, E.C, … Campagnaro, B.P. (2018). Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. Life Sciences, 209, 370–376.
Baud, D., Dimopoulou Agri, V., Gibson, G.R., Reid, G. & Giannoni, E. (2020). Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic. Frontiers in Public Health, 8, 186.
Bellikci-Koyu, E., Sarer-Yurekli, B.P., Akyon, Y., Aydin-Kose, F., Karagozlu, C., … Buyuktuncer, Z. (2019). Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study. Nutrients, 11, 2089.
Bengoa, A., Iraporda, C., Garrote, G.L. & Abraham, A.G. (2018). Kefir micro-organisms: Their role in grain assembly and health properties of fermented milk. Journal of Applied Microbiology, 126(3), 686–700.
Berbudi, A., Rahmadika, N., Tjahjadi, A.I. & Ruslami, R. (2020). Type 2 diabetes and its impact on the immune system. Current Diabetes Reviews, 16, 442.
Bourrie, B.C.T., Willing, B.P. & Cotter, P.D. (2016). The microbiota and health promoting characteristics of the fermented beverage kefir. Frontiers in Microbiology, 7, 647.
Brown, L., Caligiuri, S.P.B., Brown, D. & Pierce, G.N. (2018). Clinical trials using functional foods provide unique challenges. Journal of Functional Foods, 45, 233–238.
Chait, A. & Den Hartigh, L.J. (2020). Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Frontiers in cardiovascular medicine, 7, 22.
Chen, Y.H., Chen, H.L., Fan, H.C., Tung, Y.T., Kuo, C.W., … Chen, C.M. (2020).
Anti-Inflammatory, Antioxidant, and Antifibrotic Effects of Kefir Peptides on Salt-Induced Renal Vascular Damage and Dysfunction in Aged Stroke-Prone Spontaneously Hypertensive Rats. Antioxidants, 9, 790.
Chourasia, R., Padhi, S., Chiring Phukon, L., Abedin, M.M., Singh, S.P. & Rai, A.K. (2020). A Potential Peptide from Soy Cheese Produced Using Lactobacillus delbrueckii WS4 for Effective Inhibition of SARS-CoV-2 Main Protease and S1 Glycoprotein. Frontiers in Molecular Biosciences, 7, 601753.
Costa, G.M., Paula, M.M., Costa, G.N., Esmerino, E.A., Silva, R., … Pimentel, T. (2020). Preferred attribute elicitation methodology compared to conventional descriptive analysis: a study using probiotic yogurt sweetened with xylitol and added with prebiotic components. Journal of Sensory Studies, 35(6), e12602.
Culpepper, T. (2022). The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review. Cureus, 14(8), e27768.
Demirci, A.S., Palabiyik, I., Ozalp, S. & Tirpanci Sivri G. (2019). Effect of using kefir in the formulation of traditional Tarhana. Food Science and Technology, 39(2), 358-364.
Di Renzo, T., Reale, A., Boscaino, F. & Messia, M.C. (2018). Flavoring production in Kamut®, quinoa and wheat doughs fermented by Lactobacillus paracasei, Lactobacillus plantarum, and Lactobacillus brevis: a SPME-GC/MS study. Frontiers in Microbiology, 9, 429.
Dos Santos, D.C., De Oliveira Filho, J.G., Santana, A.C.A., De Freitas, B.S.M., Silva, F.G., … Egea, M.B. (2019). Optimization of soymilk fermentation with kefir and the addition of inulin: Physicochemical, sensory and technological characteristics. LWT, 104, 30-37.
Egea, M.B., Santos, D.C.D., Oliveira Filho, J.G.D., Ores, J.D.C., … Lemes, A.C. (2022). A review of nondairy kefir products: their characteristics and potential human health benefits. Critical Reviews in Food Science and Nutrition, (6), 1536-1552.
Farag, M.A., Jomaa, S.A., Abd El-Wahed, A. & El-Seedi, H.R. (2020). The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety. Nutrients, 12, 346.
Ficara, M., Pietrella, E., Spada, C., Della Casa Muttini, E., Lucaccioni, L., … Berardi, A. (2020). Changes of intestinal microbiota in early life. The Journal of Maternal-Fetal & Neonatal Medicine, 33(6), 1036-1043.
Flynn, J., Ryan, A. & Hudson, S.P. (2021). Pre-Formulation and Delivery Strategies for the Development of Bacteriocins as Next Generation Antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 165, 149-163.
Guzel-Seydim, Z.B., Gokirmaklı, C. & Greene, A.K. (2021). A comparison of milk kefir and water kefir: Physical, chemical, microbiological and functional properties. Trends in Food Science & Technology, 113, 42–53.
Gao, W. & Zhang, L. (2019). Comparative analysis of the microbial community composition between Tibetan kefir grains and milks. Food Research International, 116, 137–144.
Garofalo, C., Ferrocino, I., Reale, A., Sabbatini, R., Milanović, V., … Osimani, A. (2020). Study of kefir drinks produced by backslopping method using kefir grains from Bosnia and Gul, O., Atalar, I., Mortas, M. & Dervisoglu, M. (2018). Rheological, textural, colour and sensorial properties of kefir produced with buffalo milk using kefir grains and starter culture: A comparison with cows’ milk kefir. International Journal of Dairy Technology, 71, 73–80.
Herzegovina: Microbial dynamics and volatilome profile. Food Research International, 137, 109369.
Hamida, R.S., Shami, A., Ali, M.A., Almohawes, Z.N., Mohammed, A.E., Bin-Meferij, M.M. (2021). Kefir: A protective dietary supplementation against viral infection. Biomedicine & Pharmacotherapy, 133, 110974.
Hikmetoglu, M., Sogut, E., Sogut, O., Gokirmakli, C. & Guzel-Seydim, Z.B. (2020). Changes in carbohydrate profile in kefir fermentation. Bioactive Carbohydrates and Dietary Fibre, 23, 100220.
Ilıkkan, Ö.K. & Bağdat E Ş. (2021). Comparison of bacterial and fungal biodiversity of Turkish kefir grains with high-throughput metagenomic analysis. LWT, 152, 112375.
Judacewski, P., Los, P.R., Lima, L.S., Alberti, A., Zielinski, A.A.F. & Nogueira A. (2019). Perceptions of Brazilian consumers regarding white mould surface‐ripened cheese using free word association. International Journal of Dairy Technology, 72(4), 585-590.
Judiono, J., Hadisaputro, S., Indranila, K., Cahyono, B., Suzery, M., … Purnawan, A.I. (2014). Effects of clear kefir on biomolecular aspects of glycemic status of type 2 diabetes mellitus (T2DM) patients in Bandung, West Java [study on human blood glucose, c peptide and insulin]. Functional Foods in Health and Disease, 4, 340–348.
Kang, E.A., Choi, H.I., Hong, S.W., Kang, S., Jegal, H.Y., … Kim, J.S. (2020). Extracellular vesicles derived from kefir grain Lactobacillus ameliorate intestinal inflammation via regulation of proinflammatory pathway and tight junction integrity. Biomedicines, 8(11), 522.
Karaçalı, R., Özdemir, N.İ. & Çon, A.H. (2018). Aromatic and functional aspects of kefir produced using soya milk and Bifidobacterium species. International Journal of Dairy Technology, 71(4), 921-933.
Khan, R.A.A., Najeeb, S., Mao, Z., Ling, J., Yang, Y., Li, Y. & Xie, B. (2020). Bioactive secondary metabolites from Trichoderma spp. against phytopathogenic bacteria and root-knot nematode. Microorganisms, 8(3), 401.
Kim, H., Sitarik, A.R., Woodcroft, K., Johnson, C.C. & Zoratti, E. (2019). Birth mode, breastfeeding, pet exposure, and antibiotic use: associations with the gut microbiome and sensitization in children. Current Allergy and Asthma Reports, 19, 1-9.
Kivanc, M. & Yapici, E. (2019). Survival of Escherichia coli O157: H7 and Staphylococcus aureus during the fermentation and storage of kefir. Food Science and Technology, 39(Suppl. 1), 225-230.
Lim, J., Kale, M., Kim, D.H., Kim, H.S., Chon, J.W.,… Kim, H. (2017). Antiobesity effect of exopolysaccharides isolated from kefir grains. Journal of Agricultural and Food Chemistry, 65(46), 10011-10019.
Lima, J.E., Moreira, N.C. & Sakamoto-Hojo, E.T. (2022). Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia. Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 874, 503437.
Lynch, K.M., Wilkinson, S., Daenen, L. & Arendt, E.K. (2021). An update on water kefir: Microbiology, composition and production. International Journal of Food Microbiology, 345, 109128.
Matos, R.S., Lopes, G.A.C., Ferreira, N.S., Pinto, E.P., Carvalho, J.C.T, Figueiredo, S.S., … Zamora, R.R.M. (2018). Superficial Characterization of Kefir Biofilms Associated with Açaí and Cupuaçu Extracts. Arab. International Journal of Engineering Science, 43, 3371–3379.
Maoloni, A., Milanović, V., Cardinali, F., Mangia, N.P., Murgia, M.A.,… Aquilanti, L. (2020). Bacterial and fungal communities of Gioddu as revealed by PCR–DGGE analysis. Indian Journal of Microbiology, 60(1), 119-123.
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., … Ventura, M. (2017). The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiology and molecular biology reviews, 81(4), e00036-17.
Mitra, S. & Ghosh, B.C. (2020). Quality characteristics of kefir as a carrier for probiotic Lactobacillus rhamnosus GG. International Journal of Dairy Technology, 73(2), 384-391.
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