Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol
Sıçanların Epididimis ve Dalak Dokularında Kurşun ve Kadmiyuma Bağlı Oksidatif Strese Karşı Sesamolün Etkileri

Fatma APAYDIN [1] , Hatice BAŞ [2] , Yusuf KALENDER [3]


Lead and cadmium are known as environmental pollutants extensively found in food and water that induce hazards to animals’ and people’s health. Sesamol is a dietary antioxidant that is found in some plants. Epididymis is known to play an important role in the maturation and storage of the sperm. The spleen is an important organ involved in the immune response. The present study aims to analyze the oxidative stress in spleen and epididymis. Therefore, Lead (LN) (90 mg/kg bw per day, 1/25 LD50), Cadmium (CdCl2) (3 mg/kg bw per day, 1/25 LD50), and sesamol (50 mg/kg bw per day) were given to rats by gavage for 28 days. Antioxidant enzyme activities in epididymis and spleen tissues [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S transferase], malondialdehyde (MDA) were investigated at the end of 28 days comparatively with the control group. It is revealed that there is a significant decline in the antioxidant enzymes and increase in MDA levels in the spleen and epididymis tissues of the lead and cadmium treated rats compared to the control group. A small increase in these parameters was also observed in the sesamol treated groups.

Kurşun ve kadmiyum, hayvan ve insan sağlığına zarar veren gıda ve su kirleticilerinde yaygın olarak bulunan bilinen çevre kirleticileridir. Sesamol, bazı bitkilerde bulunan bir diyet antioksidanıdır. Epididimisin spermin olgunlaşması ve depolanmasında önemli bir rol oynadığı bilinmektedir. Dalak, bağışıklık tepkisinde rol oynayan önemli bir organdır. Bu çalışma, dalak ve epididimdeki oksidatif stresi analiz etmeyi amaçlamaktadır. Bu amaçla sıçanlara kurşun (günde 90 mg/kg canlı ağırlık, 1/25 LD50), kadmiyum (günde 3 mg/kg canlı ağırlık, 1/25 LD50) ve sesamol (günde 50 mg/kg canlı ağırlık) verildi. 28 gün boyunca gavaj, 28 gün sonunda epididimis ve dalak dokularındaki antioksidan enzim aktiviteleri [süperoksit dismutaz (SOD), katalaz (CAT), glutasyon peroksidaz (GPx) ve glutatyon S transferaz], malondialdehit (MDA) kontrol grubu ile karşılaştırmalı olarak araştırıldı. Kontrol grubuna göre kurşun ve kadmiyum uygulanan sıçanların dalak ve epididimis dokularında antioksidan enzimlerinde istatistiksel olarak anlamlı bir azalma ve MDA düzeylerinde artış olmuştur. Bu parametrelerde sesamol ile tedavi edilen gruplarda daha az artış gözlenmiştir.

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Birincil Dil en
Konular Biyoloji
Bölüm Araştırma Makaleleri
Yazarlar

Orcid: 0000-0002-2771-7488
Yazar: Fatma APAYDIN (Sorumlu Yazar)
Kurum: Gazı University
Ülke: Turkey


Orcid: 0000-0001-8296-0360
Yazar: Hatice BAŞ
Kurum: Yozgat Bozok University
Ülke: Turkey


Orcid: 0000-0001-5457-0517
Yazar: Yusuf KALENDER
Kurum: Gazı University
Ülke: Turkey


Tarihler

Başvuru Tarihi : 21 Eylül 2020
Kabul Tarihi : 18 Ocak 2021
Yayımlanma Tarihi : 31 Mart 2021

Bibtex @araştırma makalesi { commagene797945, journal = {Commagene Journal of Biology}, issn = {}, eissn = {2602-456X}, address = {Adıyaman Bilimsel Araştırmalar Derneği,}, publisher = {ABADER (Adıyaman Bilimsel Araştırmalar Derneği)}, year = {2021}, volume = {Erken Görünüm}, pages = {7 - 11}, doi = {10.31594/commagene.797945}, title = {Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol}, key = {cite}, author = {Apaydın, Fatma and Baş, Hatice and Kalender, Yusuf} }
APA Apaydın, F , Baş, H , Kalender, Y . (2021). Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol . Commagene Journal of Biology , Erken Görünüm , 7-11 . DOI: 10.31594/commagene.797945
MLA Apaydın, F , Baş, H , Kalender, Y . "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol" . Commagene Journal of Biology Erken Görünüm (2021 ): 7-11 <https://dergipark.org.tr/tr/pub/commagene/issue/60100/797945>
Chicago Apaydın, F , Baş, H , Kalender, Y . "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol". Commagene Journal of Biology Erken Görünüm (2021 ): 7-11
RIS TY - JOUR T1 - Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol AU - Fatma Apaydın , Hatice Baş , Yusuf Kalender Y1 - 2021 PY - 2021 N1 - doi: 10.31594/commagene.797945 DO - 10.31594/commagene.797945 T2 - Commagene Journal of Biology JF - Journal JO - JOR SP - 7 EP - 11 VL - Erken Görünüm IS - SN - -2602-456X M3 - doi: 10.31594/commagene.797945 UR - https://doi.org/10.31594/commagene.797945 Y2 - 2021 ER -
EndNote %0 Kommagene Biyoloji Dergisi Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol %A Fatma Apaydın , Hatice Baş , Yusuf Kalender %T Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol %D 2021 %J Commagene Journal of Biology %P -2602-456X %V Erken Görünüm %N %R doi: 10.31594/commagene.797945 %U 10.31594/commagene.797945
ISNAD Apaydın, Fatma , Baş, Hatice , Kalender, Yusuf . "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol". Commagene Journal of Biology Erken Görünüm / (Mart 2021): 7-11 . https://doi.org/10.31594/commagene.797945
AMA Apaydın F , Baş H , Kalender Y . Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Comm. J. Biol.. 2021; Erken Görünüm: 7-11.
Vancouver Apaydın F , Baş H , Kalender Y . Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Commagene Journal of Biology. 2021; Erken Görünüm: 7-11.
IEEE F. Apaydın , H. Baş ve Y. Kalender , "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol", Commagene Journal of Biology, c. Erken Görünüm, ss. 7-11, Mar. 2021, doi:10.31594/commagene.797945