Ürolitin-A’nın Non-Enfeksiyöz İshalli Buzağılarda Dışkı Skorları Üzerine Etkinliğinin Araştırılması

Öz

Amaç: Bu araştırmada amaç, fonksiyonel gıda özelliğine sahip olan Ürolithin-a' (Ür-a)’nın enfeksiyöz olmayan ishalli buzağılarda doğal tedavi katılımcısı olarak etki edip edemeyeceğini multidisipliner olarak tespit etmektir. Gereç ve Yöntem: Bu amaçla 1 ila 28 günlük ishalli neonatal buzağılar arasından seçilerek, non-enfeksiyöz etiyolojiye sahip olan 40 buzağı çalışmaya dahil edildi. Enfeksiyöz ve enfeksiyöz olmayan ishaller arasında ayırıcı tanı için mikrobiyolojik, parazitolojik ve virolojik laboratuvar testlerine dayalı bir algoritma kullanıldı. Dışkı puanlaması 0 (normal kıvam) ile 3 (sıvı form) arasında bir ölçekle yapıldı. Ür-a, herhangi bir yan etki olmaksızın 10 ardışık gün boyunca 50 mg/kg dozunda oral yoldan uygulandı. Bulgular: Ür-a uygulamasına ilişkin olarak dışkı skorları (ortalama±standart sapma) önceki başlangıç değerleri olan 1.826 ± 0.242'ye (p < 0,01) kıyasla 0'a düştü. Sonuç: Elde edilen veriler, bu ön sonuçların non-infeksiyöz ishalli buzağılarda Ür-a'nın gastrointestinal sağlığı destekleyici etkinliğine sahip olabileceğini gösterebilir. İleriki çalışmaların gerçekleştirilmesi gerekliliği, bir sonraki çalışmamızın amacı olacaktır

Anahtar Kelimeler

• Buzağı
• ishal
• non-enfeksiyöz
• urolithin-a

Investigation Of The Effectiveness Of Urolithin-A On Fecal Scores In Calves With Non-İnfectious Diarrhea

Öz

Aim: The aim of this study was to determine multidisciplinary whether Urolithin-a (Ur-a), which has functional food properties, can be effective as a natural treatment agent in calves with non-infectious diarrhea. Materials and Methods: For this purpose, neonatal calves with diarrhea aged 1 to 28 days and 40 calves selected with non-infectious etiology were included in the study. An algorithm based on microbiological, parasitological and virological laboratory tests was used for differential diagnosis between infectious and non-infectious diarrhea. Stool scoring was done on a scale from 0 (normal consistency) to 3 (liquid form). Ur-a was administered orally at a dose of 50 mg/kg for 10 consecutive days without any side effects. Results: With regard to Ur-a administration, fecal scores (mean±standard deviation) decreased to 0 compared to the previous baseline values of 1.826 ± 0.242 (p < 0.01). Conclusion: The obtained data may indicate that these preliminary results may have the efficacy of Ur-a in supporting gastrointestinal health in calves with non-infectious diarrhea. The need for further studies will be the aim of our next study.

Anahtar Kelimeler

• Calf
• diarrhea
• non-infectious
• Urolithin-a

Kaynakça

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