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Gebelikte Bireysel Kullanılan Seçici Serotonin Gerialım İnhibitörleri Yenidoğan ve Çocukluktaki Riskler Açısından Farklılık Gösteriyor Mu: Genel Bakış

Yıl 2022, Cilt: 2 Sayı: 1, 48 - 62, 16.06.2022

Öz

Bu derleme, hamilelik sırasında seçici serotonin geri alım inhibitörlerinin (SSRI’lar) annede bireysel kullanımıyla ilişkili yenidoğan ve çocukluktaki sonuçların risklerine ilişkin mevcut verileri özetlemektedir. Ocak 2005 ile Nisan 2020 arasında İngilizce ve PubMed'de yayınlanan araştırma makaleleri ve meta-analizler tarandı. Sınırlı mevcut verilere göre, diğerlerine kıyasla, bireysel SSRI’larla ilişkili biraz daha yüksek riskler şu şekildedir: erken doğum için paroksetin, düşük doğum ağırlığı için essitalopram, spontan düşük için sertralin ve paroksetin, kalıcı pulmoner hipertansiyon için fluoksetin ve zayıf yenidoğan adaptasyon sendromu olanlar için fluoksetin ve paroksetin. Kalıcı pulmoner hipertansiyon için sertralin ve otizm spektrum bozuklukları için sertralin ve paroksetin diğer SSRI’lara kıyasla nispeten daha güvenli olabilir. Mevcut kanıtlar kesin sonuçlar için yetersizdir. Daha fazla çok merkezli karşılaştırmalı çalışmalara acilen ihtiyaç vardır.

Kaynakça

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Do Individual Selective Serotonin Reuptake Inhibitors Used During Pregnancy Show Any Differences in The Risk of Neonatal and Childhood Outcomes: An Overview

Yıl 2022, Cilt: 2 Sayı: 1, 48 - 62, 16.06.2022

Öz

This review summarizes current data on the risk of neonatal and childhood outcomes associated with maternal use of individual selective serotonin reuptake inhibitors (SSRIs) during pregnancy. Research articles and meta-analyses published in English language and curated in PubMed between January 2005 and April 2020 were screened. Based on limited available data, compared to others, slightly higher risks associated with individual SSRIs are as follows: paroxetine for preterm birth, escitalopram for low birth weight, sertraline and paroxetine for spontaneous abortion, fluoxetine for persistent pulmonary hypertension and fluoxetine and paroxetine for poor neonatal adapdation syndrome. Sertraline for persistent pulmonary hypertension and sertraline and paroxetine for autism spectrum disorders may be relatively safer compared to the other SSRIs. The current evidence is inadequate for definitive conclusions. Futher multicenter comparative studies are urgently needed.

Kaynakça

  • Aarnoudse-Moens, C. S., Weisglas-Kuperus, N., van Goudoever, J. B., & Oosterlaan, J. (2009). Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics, 124(2), 717-728. https://doi.org/10.1542/peds.2008-2816
  • Allotey, J., Zamora, J., Cheong-See, F., Kalidindi, M., Arroyo-Manzano, D., Asztalos, E., van der Post, J., Mol, B. W., Moore, D., Birtles, D., Khan, K. S., & Thangaratinam, S. (2018). Cognitive, motor, behavioural and academic performances of children born preterm: A meta-analysis and systematic review involving 64 061 children. BJOG: An International Journal of Obstetrics and Gynaecology, 125(1), 16-25. https://doi.org/10.1111/1471-0528.14832
  • Andalib, S., Emamhadi, M. R., Yousefzadeh-Chabok, S., Shakouri, S. K., Høilund-Carlsen, P. F., Vafaee, M. S., & Michel, T. M. (2017). Maternal SSRI exposure increases the risk of autistic offspring: A meta-analysis and systematic review. European Psychiatry: The Journal of The Association of European Psychiatrists, 45, 161-166. https://doi.org/10.1016/j.eurpsy.2017.06.001
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  • Grigoriadis, S., VonderPorten, E. H., Mamisashvili, L., Eady, A., Tomlinson, G., Dennis, C. L., Koren, G., Steiner, M., Mousmanis, P., Cheung, A., & Ross, L. E. (2013a). The effect of prenatal antidepressant exposure on neonatal adaptation: A systematic review and meta-analysis. The Journal of Clinical Psychiatry, 74(4), 309-320. https://doi.org/10.4088/JCP.12r07967
  • Grigoriadis, S., VonderPorten, E. H., Mamisashvili, L., Roerecke, M., Rehm, J., Dennis, C. L., Koren, G., Steiner, M., Mousmanis, P., Cheung, A., & Ross, L. E. (2013c). Antidepressant exposure during pregnancy and congenital malformations: is there an association? A systematic review and meta-analysis of the best evidence. The Journal of Clinical Psychiatry, 74(4), 293-308. https://doi.org/10.4088/JCP.12r07966
  • Grigoriadis, S., VonderPorten, E. H., Mamisashvili, L., Tomlinson, G., Dennis, C. L., Koren, G., Steiner, M., Mousmanis, P., Cheung, A., Radford, K., Martinovic, J., & Ross, L. E. (2013b). The impact of maternal depression during pregnancy on perinatal outcomes: A systematic review and meta-analysis. The Journal of Clinical Psychiatry, 74(4), 321-341. https://doi.org/10.4088/JCP.12r07968
  • Grigoriadis, S., Vonderporten, E. H., Mamisashvili, L., Tomlinson, G., Dennis, C. L., Koren, G., Steiner, M., Mousmanis, P., Cheung, A., & Ross, L. E. (2014). Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: Systematic review and meta-analysis. BMJ, 348, f6932. https://doi.org/10.1136/bmj.f6932
  • Grote, N. K., Bridge, J. A., Gavin, A. R., Melville, J. L., Iyengar, S., & Katon, W. J. (2010). A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Archives of General Psychiatry, 67(10), 1012-1024. https://doi.org/10.1001/archgenpsychiatry.2010.111
  • Grzeskowiak, L. E., Gilbert, A. L., & Morrison, J. L. (2012). Neonatal outcomes after late-gestation exposure to selective serotonin reuptake inhibitors. Journal of Clinical Psychopharmacology, 32(5), 615-621. https://doi.org/10.1097/JCP.0b013e31826686bc
  • Halvorsen, A., Hesel, B., Østergaard, S. D., & Danielsen, A. A. (2019). In utero exposure to selective serotonin reuptake inhibitors and development of mental disorders: A systematic review and meta-analysis. Acta Psychiatrica Scandinavica, 139(6), 493-507. https://doi.org/10.1111/acps.13030
  • Hayes, R. M., Wu, P., Shelton, R. C., Cooper, W. O., Dupont, W. D., … Hartert, T. V. (2012). Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies. American Journal of Obstetrics and Gynecology, 207(1), 49.e1-49.e499. https://doi.org/10.1016/j.ajog.2012.04.028
  • Hemels, M. E., Einarson, A., Koren, G., Lanctôt, K. L., & Einarson, T. R. (2005). Antidepressant use during pregnancy and the rates of spontaneous abortions: A meta-analysis. The Annals of Pharmacotherapy, 39(5), 803-809. https://doi.org/10.1345/aph.1E547
  • Huang, H., Coleman, S., Bridge, J. A., Yonkers, K., & Katon, W. (2014). A meta-analysis of the relationship between antidepressant use in pregnancy and the risk of preterm birth and low birth weight. General Hospital Psychiatry, 36(1), 13-18. https://doi.org/10.1016/j.genhosppsych.2013.08.002
  • Jiang, H. Y., Peng, C. T., Zhang, X., & Ruan, B. (2018). Antidepressant use during pregnancy and the risk of attention-deficit/hyperactivity disorder in the children: a meta-analysis of cohort studies. BJOG: An International Journal of Obstetrics and Gynaecology, 125(9), 1077-1084. https://doi.org/10.1111/1471-0528.15059
  • Källén, B., & Olausson, P. O. (2008). Maternal use of selective serotonin re-uptake inhibitors and persistent pulmonary hypertension of the newborn. Pharmacoepidemiology and Drug Safety, 17(8), 801-806. https://doi.org/10.1002/pds.1570
  • Kaplan, Y. C., Keskin-Arslan, E., Acar, S., & Sozmen, K. (2016). Prenatal selective serotonin reuptake inhibitor use and the risk of autism spectrum disorder in children: A systematic review and meta-analysis. Reproductive Toxicology, 66, 31-43. https://doi.org/10.1016/j.reprotox.2016.09.013
  • Kaplan, Y. C., Keskin-Arslan, E., Acar, S., & Sozmen, K. (2017). Maternal SSRI discontinuation, use, psychiatric disorder and the risk of autism in children: a meta-analysis of cohort studies. British Journal of Clinical Pharmacology, 83(12), 2798-2806. https://doi.org/10.1111/bcp.13382
  • Kieler, H., Artama, M., Engeland, A., Ericsson, O., Furu, K., … Haglund, B. (2012). Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population-based cohort study from the five Nordic countries. BMJ, 344, d8012. https://doi.org/10.1136/bmj.d8012
  • Kieviet, N., Dolman, K. M., & Honig, A. (2013). The use of psychotropic medication during pregnancy: How about the newborn? Neuropsychiatric Disease and Treatment, 9, 1257-1266. https://doi.org/10.2147/NDT.S36394
  • Kjaersgaard, M. I., Parner, E. T., Vestergaard, M., Sørensen, M. J., Olsen, J., … Pedersen, L. H. (2013). Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study. PloS One, 8(8), e72095. https://doi.org/10.1371/journal.pone.0072095
  • Klieger-Grossmann, C., Weitzner, B., Panchaud, A., Pistelli, A., Einarson, T., … Einarson, A. (2012). Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study. Journal of Clinical Pharmacology, 52(5), 766-770. https://doi.org/10.1177/0091270011405524
  • Klinger, G., & Merlob, P. (2008). Selective serotonin reuptake inhibitor induced neonatal abstinence syndrome. The Israel Journal of Psychiatry and Related Sciences, 45(2), 107-113.
  • Lattimore, K. A., Donn, S. M., Kaciroti, N., Kemper, A. R., Neal, C. R., Jr, & Vazquez, D. M. (2005). Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and effects on the fetus and newborn: a meta-analysis. Journal of Perinatology: Official Journal of The California Perinatal Association, 25(9), 595-604. https://doi.org/10.1038/sj.jp.7211352
  • Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J. (2018). Autism spectrum disorder. Lancet, 392(10146), 508-520. https://doi.org/10.1016/S0140-6736(18)31129-2
  • Man, K. K., Tong, H. H., Wong, L. Y., Chan, E. W., Simonoff, E., & Wong, I. C. (2015). Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neuroscience and Biobehavioral Reviews, 49, 82-89. https://doi.org/10.1016/j.neubiorev.2014.11.020
  • Man, K., Chan, E. W., Ip, P., Coghill, D., Simonoff, E., Chan, P., Lau, W., Schuemie, M. J., Sturkenboom, M., & Wong, I. (2018). Prenatal antidepressant exposure and the risk of attention-deficit hyperactivity disorder in children: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 86, 1-11. https://doi.org/10.1016/j.neubiorev.2017.12.007
  • Masarwa, R., Bar-Oz, B., Gorelik, E., Reif, S., Perlman, A., & Matok, I. (2019). Prenatal exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors and risk for persistent pulmonary hypertension of the newborn: A systematic review, meta-analysis, and network meta-analysis. American Journal of Obstetrics and Gynecology, 220(1), 57.e1-57.e13. https://doi.org/10.1016/j.ajog.2018.08.030
  • McDonagh, M. S., Matthews, A., Phillipi, C., Romm, J., Peterson, K., Thakurta, S., & Guise, J. M. (2014). Depression drug treatment outcomes in pregnancy and the postpartum period: a systematic review and meta-analysis. Obstetrics and Gynecology, 124(3), 526-534. https://doi.org/10.1097/AOG.0000000000000410
  • Meunier, M. R., Bennett, I. M., & Coco, A. S. (2013). Use of antidepressant medication in the United States during pregnancy, 2002-2010. Psychiatric Services, 64(11), 1157-1160. https://doi.org/10.1176/appi.ps.201200455
  • Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017). Environmental risk factors for autism: An evidence-based review of systematic reviews and meta-analyses. Molecular Autism, 8, 13. https://doi.org/10.1186/s13229-017-0121-4
  • Molenaar, N. M., Bais, B., Lambregtse-van den Berg, M. P., Mulder, C. L., Howell, E. A., Fox, N. S., Rommel, A. S., Bergink, V., & Kamperman, A. M. (2020). The international prevalence of antidepressant use before, during, and after pregnancy: A systematic review and meta-analysis of timing, type of prescriptions and geographical variability. Journal of Affective Disorders, 264, 82-89. https://doi.org/10.1016/j.jad.2019.12.014
  • Munk-Olsen, T., Gasse, C., & Laursen, T. M. (2012). Prevalence of antidepressant use and contacts with psychiatrists and psychologists in pregnant and postpartum women. Acta Psychiatrica Scandinavica, 125(4), 318-324. https://doi.org/10.1111/j.1600-0447.2011.01784.x
  • Nakhai-Pour, H. R., Broy, P., & Bérard, A. (2010). Use of antidepressants during pregnancy and the risk of spontaneous abortion. CMAJ: Canadian Medical Association Journal, 182(10), 1031-1037. https://doi.org/10.1503/cmaj.091208
  • Ng, Q. X., Venkatanarayanan, N., Ho, C., Sim, W. S., Lim, D. Y., & Yeo, W. S. (2019). Selective Serotonin Reuptake Inhibitors and Persistent Pulmonary Hypertension of the Newborn: An Update Meta-Analysis. Journal of Women’s Health, 28(3), 331-338. https://doi.org/10.1089/jwh.2018.7319
  • Occhiogrosso, M., Omran, S. S., & Altemus, M. (2012). Persistent pulmonary hypertension of the newborn and selective serotonin reuptake inhibitors: lessons from clinical and translational studies. The American Journal of Psychiatry, 169(2), 134-140. https://doi.org/10.1176/appi.ajp.2011.11040553
  • Roca, A., Garcia-Esteve, L., Imaz, M. L., Torres, A., Hernández, S., … Martin-Santos, R. (2011). Obstetrical and neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitors: The relevance of dose. Journal of Affective Disorders, 135(1-3), 208-215. https://doi.org/10.1016/j.jad.2011.07.022
  • Sanz, E. J., De-las-Cuevas, C., Kiuru, A., Bate, A., & Edwards, R. (2005). Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: A database analysis. Lancet, 365(9458), 482-487. https://doi.org/10.1016/S0140-6736(05)17865-9
  • Sciberras, E., Mulraney, M., Silva, D., & Coghill, D. (2017). Prenatal risk factors and the etiology of ADHD-review of existing evidence. Current Psychiatry Reports, 19(1), 1. https://doi.org/10.1007/s11920-017-0753-2
  • Sharifi, N., Khazaeian, S., Pakzad, R., Fathnezhad Kazemi, A., & Chehreh, H. (2017). Investigating the Prevalence of Preterm Birth in Iranian Population: A Systematic Review and Meta-Analysis. Journal of Caring Sciences, 6(4), 371-380. https://doi.org/10.15171/jcs.2017.035
  • Sharma, V., Berkelhamer, S., & Lakshminrusimha, S. (2015). Persistent pulmonary hypertension of the newborn. Maternal Health, Neonatology and Perinatology, 1, 14. https://doi.org/10.1186/s40748-015-0015-4
  • Simon, G. E., Cunningham, M. L., & Davis, R. L. (2002). Outcomes of prenatal antidepressant exposure. The American Journal of Psychiatry, 159(12), 2055-2061. https://doi.org/10.1176/appi.ajp.159.12.2055
  • Sivojelezova, A., Shuhaiber, S., Sarkissian, L., Einarson, A., & Koren, G. (2005). Citalopram use in pregnancy: Prospective comparative evaluation of pregnancy and fetal outcome. American Journal of Obstetrics and Gynecology, 193(6), 2004-2009. https://doi.org/10.1016/j.ajog.2005.05.012
  • Suri, R., Altshuler, L., Hellemann, G., Burt, V. K., Aquino, A., & Mintz, J. (2007). Effects of antenatal depression and antidepressant treatment on gestational age at birth and risk of preterm birth. The American Journal of Psychiatry, 164(8), 1206-1213. https://doi.org/10.1176/appi.ajp.2007.06071172
  • Thomas, R., Sanders, S., Doust, J., Beller, E., & Glasziou, P. (2015). Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Pediatrics, 135(4), 994-1001. https://doi.org/10.1542/peds.2014-3482
  • Tucker, J., & McGuire, W. (2004). Epidemiology of preterm birth. BMJ, 329(7467), 675-678. https://doi.org/10.1136/bmj.329.7467.675
  • Uguz F. (2016). A pharmacological approach to panic disorder during pregnancy. The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of The European Association of Perinatal Medicine, The Federation of Asia And Oceania Perinatal Societies, The International Society of Perinatal Obstetricians, 29(9), 1468-1475. https://doi.org/10.3109/14767058.2015.1051025
  • Uguz F. (2018). Maternal antidepressant use during pregnancy and the risk of attention-deficit/hyperactivity disorder in children: A systematic review of the current literature. Journal of Clinical Psychopharmacology, 38(3), 254-259. https://doi.org/10.1097/JCP.0000000000000868
  • Viktorin, A., Uher, R., Reichenberg, A., Levine, S. Z., & Sandin, S. (2017). Autism risk following antidepressant medication during pregnancy. Psychological Medicine, 47(16), 2787-2796. https://doi.org/10.1017/S0033291717001301
  • Wen, S. W., Smith, G., Yang, Q., & Walker, M. (2004). Epidemiology of preterm birth and neonatal outcome. Seminars in Fetal & Neonatal Medicine, 9(6), 429-435. https://doi.org/10.1016/j.siny.2004.04.002
  • Xu, J., Barinas-Mitchell, E., Kuller, L. H., Youk, A. O., & Catov, J. M. (2014). Maternal hypertension after a low-birth-weight delivery differs by race/ethnicity: Evidence from the National Health and Nutrition Examination Survey (NHANES) 1999-2006. PloS One, 9(8), e104149. https://doi.org/10.1371/journal.pone.0104149
  • Yadav, H., & Lee, N. (2013). Maternal factors in predicting low birth weight babies. The Medical Journal of Malaysia, 68(1), 44-47.
  • Yonkers, K. A., Blackwell, K. A., Glover, J., & Forray, A. (2014). Antidepressant use in pregnant and postpartum women. Annual Review of Clinical Psychology, 10, 369-392. https://doi.org/10.1146/annurev-clinpsy-032813-153626
Toplam 70 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Psikiyatri
Bölüm Derlemeler
Yazarlar

Faruk Uğuz Bu kişi benim 0000-0002-6876-5005

Sena Karaca 0000-0002-7587-0022

Yayımlanma Tarihi 16 Haziran 2022
Gönderilme Tarihi 16 Ocak 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 2 Sayı: 1

Kaynak Göster

APA Uğuz, F., & Karaca, S. (2022). Do Individual Selective Serotonin Reuptake Inhibitors Used During Pregnancy Show Any Differences in The Risk of Neonatal and Childhood Outcomes: An Overview. Current Research and Reviews in Psychology and Psychiatry, 2(1), 48-62.