Relationship of blood 25-hydroxy vitamin D level with fibrocystic breast disease and breast density
Abstract
Purpose: The aim of this study is to evaluate the association of blood 25-hydroxy vitamin D levels with fibrocystic breast masses and breast patterns.
Materials and Methods: The study included 612 patients who presented with breast complaints or referred for routine screening between 2018-2021 and were requested to have breast ultrasonography (USG) and mammography (MG) examinations. Patients were divided into two groups; group 1 consisted of women with fibrocystic mass (BI-RADS 2-3) and group 2 consisted of women without breast mass (BI-RADS 1). These two groups were compared by age, breast USG, MG results, and blood 25-hydroxy vitamin D levels.
Results: Of the 612 patients, 310 (51%) had fibrocystic mass in their breasts, while 302 (49%) had normal breasts. The mean age of both groups was similar. Those with fibrocystic mass in the breast had lower vitamin D levels and higher breast density than the control group. The group with higher breast density had lower vitamin D levels, and there was a negative correlation between vitamin D level and breast density
Conclusion: Our study revealed that women with fibrocystic masses in their breasts (BI- RADS2 and BI-RADS3) had higher breast density and lower vitamin D levels than women without breast mass.
Keywords
Kaynakça
- Guray M, Sahin AA. Benign breast diseases: classification, diagnosis and management. Oncologist. 2006;11:435–49.
- Talaei A, Moradi A, Rafiei F. The evaluation of the effect of metformin on breast fibrocystic disease. Breast Dis. 2017;37:49-53.
- Gopalani S V, Janitz AE, Martinez SA, Gutman P, Khan S, Campbell JE. Trends in cancer incidence among American indians and Alaska natives and non-hispanic whites in the United States, 1999-2015. Epidemiology. 2020;31:205–13.
- Ameen F, Reda SA, El-Shatoury SA, Riad EM, Enany ME, Alarfaj AA. Prevalence of antibiotic resistant mastitis pathogens in dairy cows in Egypt and potential biological control agents produced from plant endophytic actinobacteria. Saudi J Biol Sci. 2019;26:1492–8.
- Lundberg FE, Iliadou AN, Rodriguez-Wallberg K, Gemzell-Danielsson K, Johansson ALV. The risk of breast and gynecological cancer in women with a diagnosis of infertility: A nationwide population-based study. Eur J Epidemiol. 2019;34:499–507.
- Li YR, Tang YX, Qiu CX, Lin QY, Xie CJ, Zhou MY et al. Analysis of common gynecological diseases in 1142 married female workers. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2019;37:785–8.
- Autenshlyus AI, Studenikina AA, Bernado AV, Mikhailova ES, Proskura AV, Sidorov SV et al. Assessment of the cytokine-producing resource of tumor biopsy samples from patients with invasive carcinoma of no special type and with non-malignant breast diseases. Biomed Khim. 2019;65:418–23.
- Luo WQ, Huang QX, Huang XW, Hu HT, Zeng FQ, Wang W. Predicting breast cancer in Breast Imaging Reporting and Data System (BI-RADS) Ultrasound category 4 or 5 lesions: a nomogram combining radiomics and BI-RADS. Sci Rep. 2019;9:11921.
- Zhang F, Jin L, Jia C, Shi Q. The role of contrast-enhanced ultrasound in the diagnosis of malignant non-mass breast lesions and exploration of diagnostic criteria. Br J Radiol. 2021;94:1120.
- Alikhassi A, Esmaili Gourabi H, Baikpour M. Comparison of inter- and intra-observer variability of breast density assessments using the fourth and fifth editions of Breast Imaging Reporting and Data System. Eur J Radiol Open. 2018;5:67-72.
