Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions
Öz
Purpose: In this study, we applied platelet rich fibrin (PRF) and pure olive oil on the incision surfaces of rats. We aimed to examine whether PRF may be used safely to prevent peritoneal adhesions.
Materials and Methods: Fourty rats were divided into 4 groups (n=8). Eight rats, not included in the study groups, were used to obtain PRF material. Group 1 had no surgical procedure, Group 2 was operated without medication, Group 3 was operated and received 1cc olive oil, Group 4 was operated and received 1 cc PRF. After 21 days, cecum areas were examined histopathologically. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were measured in serum by ELISA.
Results: The adhesion scores and severity of fibrosis in Group 3 and 4 were significantly lower than Group 2. Plasma TNF-α value was significantly higher in Group 2 than Group 4. Plasma PDGF value was significantly higher in Group 2 than Group 3 and 4.
Discussion: PRF reduced intestinal adhesion by inhibiting the proliferation of fibroblasts and inflammatory cells, and promoting the proliferation of mesothelial cells. PRF has anti-inflammatory effect and prevented postop adhesions, based mainly on growth factors and cytokines in its content.
Anahtar Kelimeler
postoperatıve perıtoneal adhesıons, platelet rich fibrin, pure olive oil
Teşekkür
Dear Editor-in-Chief,
Please find enclosed our manuscript, “Investigation of the Efficacy of Pure Olive Oil and Prf in Preventıng Postoperative Peritoneal Adhesions in Rats" by Dilan Altıntaş Ural et al. which we would like to submit for publication as an original article in Cukurova Medical Journal.
We believe this study is interesting to a global audience since it will make contributions to literature and serve well especially to paediatric surgeons. Thus with this features, we hope this article will be found suitable to be published in this precious journal.
All of the authors declare that they have all participated in the design, execution, and analysis of the paper, and that they have approved the final version. Additionally, there are no conflicts of interest in connection with this paper and the material described is not under publication or consideration for publication elsewhere.
Thank you for your valuable time.Yours sincerely,
Corresponding Author:
Dr.Dilan Altıntaş URAL, Assistant Professor, Md
Mailing Address: Balgat Mahallesi, Mevlana Caddesi, 1422. Sokak, No: 4, 06520, Çankaya/Ankara
E-mail: dilanaltintas@yahoo.com
Contact Phone Number :+90 505 8120302
Kaynakça
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