Clinical and radiological features of COVID-19 infection in pediatric hematology-oncology and transplant patients
Öz
Purpose: The goal of this study is to explain the characteristics of COVID-19 in this demographic, as well as the impact it had on pediatric cancer care during the pandemic.
Materials and Methods: Fifteen COVID-19 patients diagnosed were studied retrospectively. Clinical, laboratory and radiological data were collected in relation to 15 patients under the age of 18 who tested positive for Sars-CoV-2.
Results: Of the 12117 pediatric hemato-oncological patients tested for COVID-19, 1125 patients showed symptoms, and 14 tested positive. The majority of cases suffered minor illnesses. A total of ten children required inpatient care, five needed oxygen support, and four required mechanical ventilation and later died. It was noted that the duration of real-time polymerase chain reaction (RT-PCR) positivity was prolonged in patients receiving intensive chemotherapy and/or immunosuppressive therapy. Patients’ chemotherapy was delayed in all 15 (100%) Sars-CoV-2-positive patients. Although changes visible on chest computed tomography (CT) imaging of children were mainly milder than in adults, radiological findings were more severe in patients who received relatively intensive cancer treatment.
Conclusion: Children who have been treated for cancer or who have undergone a hematopoietic stem cell transplantation (HSCT) may be at greater risk of severe COVID-19 and should be under constant observation.
Anahtar Kelimeler
Chemotherapy, COVID-19, immunocompromised, pediatric, hematology, oncology, Sars-CoV-2
Kaynakça
- Alp EE, Dalgic N, Yilmaz V, Altuntas Y, Ozdemir HM. Evaluation of patients with suspicion of covıd-19 in pediatric emergency department. Med Bull Sisli Etfal Hosp. 2021;55:179-87
- World Health Organization. Coronavirus Disease (COVID-19) Pandemic. Geneva, WHO, 2020.
- Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145:e20200702.
- Çokuğraş H, Önal P. SARS-CoV-2 infection in children. Turk Pediatr Ars. 2020;55:95-102.
- Evliyaoğlu O. Children with chronic disease and COVID-19. Turk Pediatr Ars. 2020;55:93-4.
- Hijano DR, Maron G, Hayden RT. Respiratory viral infections in patients with cancer or undergoing hematopoietic cell transplant. Front Microbiol. 2018;9:3097.
- Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109:1088-95.
- Dayal D. We urgently need guidelines for managing COVID-19 in children with comorbidities. Acta Paediatr. 2020;109:1497-8.
- Chen Z, Xiong H, Li JX, Li H, Tao F, Yang YT et al. COVID-19 with post-chemotherapy agranulocytosis in childhood acute leukemia: a case report. Zhonghua Xue Ye Xue Za Zhi. 2020;41:341-3.
- Bouffet E, Challinor J, Sullivan M, Biondi A, Rodriguez-Galindo C, Pritchard-Jones K. Early advice on managing children with cancer during the COVID‐19 pandemic and a call for sharing experiences. Pediatr Blood Cancer. 2020;67:e28327.
